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公开(公告)号：US20230211000A1
公开(公告)日：2023-07-06
申请号：US17888072
申请日：2022-08-15
发明人： Stacey J. Hansen , Claudia Jochheim , Dennis M. Miller , Natalie Winblade Nairn , Julia E. Novak , Mark R. Stroud , Valorie R. Wiss , Kelly Byrnes-Blake , Scott Presnell
IPC分类号： A61K47/64 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/00 , A61B6/03 , A61B6/00 , A61K49/00 , A61K51/08 , C07K14/435 , C07K14/47 , C07K16/24
CPC分类号： A61K47/6415 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/0071 , A61B6/037 , A61B6/4057 , A61B6/481 , A61K49/0056 , A61K49/0058 , A61K51/08 , C07K14/43518 , C07K14/43522 , C07K14/4726 , C07K16/244 , C07K16/248 , A61B5/055
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US20200262877A1
公开(公告)日：2020-08-20
申请号：US16650350
申请日：2018-10-08
IPC分类号： C07K14/435 , A61P25/08 , A61P3/04 , A61P37/00 , A61P35/00 , A61P19/02 , A61P25/28 , A61P1/00 , A61P13/12 , A61P25/02
摘要： Disclosed herein are compositions and methods of use comprising peptides that bind to ion channels. Such peptides can function as active agents that target ion channels to inhibit or activate ion channels in a target tissue or cell type. In some embodiments, such peptides can be conjugated to another active agent or a detectable label.
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3.发明授权公开(公告)号：US11866466B2
公开(公告)日：2024-01-09
申请号：US16954190
申请日：2018-12-18
发明人： Natalie Winblade Nairn , Julia Novak , Kenneth Grabstein , Dennis Miller , Greg T. Hermanson , Scott R. Presnell , Mark Stroud
摘要： Peptide-immuno-oncology agent complexes (“peptide-I/O complexes”) that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.
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公开(公告)号：US20210260205A1
公开(公告)日：2021-08-26
申请号：US17230353
申请日：2021-04-14
发明人： Julia E. Novak , Natalie Winblade Nairn , Dennis M. Miller , Scott Presnell , Claudia Jochheim , Mark Stroud
IPC分类号： A61K47/64 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/00 , A61B6/03 , A61B6/00 , A61K49/00 , A61K51/08 , C07K14/435 , C07K14/47 , C07K16/24
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US12048750B2
公开(公告)日：2024-07-30
申请号：US17888072
申请日：2022-08-15
发明人： Stacey J. Hansen , Claudia Jochheim , Dennis M. Miller , Natalie Winblade Nairn , Julia E. Novak , Mark R. Stroud , Valorie R. Wiss , Kelly Byrnes-Blake , Scott Presnell
IPC分类号： A61K38/00 , A61B5/00 , A61B6/00 , A61B6/03 , A61B6/40 , A61K47/64 , A61K47/65 , A61K49/00 , A61K51/08 , A61P13/12 , A61P19/02 , C07K14/435 , C07K14/47 , C07K16/24 , A61B5/055 , A61B8/08
CPC分类号： A61K47/6415 , A61B5/0071 , A61B6/037 , A61B6/4057 , A61B6/481 , A61K47/65 , A61K49/0056 , A61K49/0058 , A61K51/08 , A61P13/12 , A61P19/02 , C07K14/43518 , C07K14/43522 , C07K14/4726 , C07K16/244 , C07K16/248 , A61B5/055 , A61B8/481 , A61B2505/05 , C07K2319/30 , C07K2319/33 , C07K2319/50
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US11559580B1
公开(公告)日：2023-01-24
申请号：US17409661
申请日：2021-08-23
发明人： Stacey J. Hansen , Claudia Jochheim , Dennis M. Miller , Natalie Winblade Nairn , Julia E. Novak , Mark R. Stroud , Valorie R. Wiss , Kelly Byrnes-Blake , Scott Presnell
IPC分类号： A61K38/00 , A61K47/64 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/00 , A61B6/03 , A61B6/00 , A61K49/00 , A61K51/08 , C07K14/435 , C07K14/47 , C07K16/24 , A61B5/055 , A61B8/08
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US11331393B2
公开(公告)日：2022-05-17
申请号：US16621173
申请日：2018-06-14
IPC分类号： A61K47/64 , A61P13/12 , A61K49/00 , A61K51/08 , A61B17/00 , A61K47/65 , C07K14/47 , A61B6/00 , A61B17/12 , A61M1/36 , A61M25/10
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptide-active agent conjugates are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the kidney. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US11013814B2
公开(公告)日：2021-05-25
申请号：US16492914
申请日：2018-03-16
发明人： Julia E. Novak , Natalie Winblade Nairn , Dennis M. Miller , Scott Presnell , Claudia Jochheim , Mark Stroud
IPC分类号： A61K47/00 , A61K47/64 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/00 , A61B6/03 , A61B6/00 , A61K49/00 , A61K51/08 , C07K14/435 , C07K14/47 , C07K16/24 , A61B5/055 , A61B8/08
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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