公开(公告)号：US20200069812A1

公开(公告)日：2020-03-05

申请号：US16492914

申请日：2018-03-16

Applicant: BLAZE BIOSCIENCE, INC.

Inventor： Julia E. Novak ,  Natalie Winblade Naim ,  Dennis M. Miller ,  Scott Presnell ,  Claudia Jochheim ,  Mark Stroud

IPC: A61K47/64 ,  C07K16/24 ,  C07K14/435 ,  C07K14/47 ,  A61K49/00 ,  A61P19/02 ,  A61K51/08 ,  A61K47/65 ,  A61P13/12 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00

Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

公开(公告)号：US11013814B2

公开(公告)日：2021-05-25

申请号：US16492914

申请日：2018-03-16

Applicant: BLAZE BIOSCIENCE, INC.

Inventor： Julia E. Novak ,  Natalie Winblade Nairn ,  Dennis M. Miller ,  Scott Presnell ,  Claudia Jochheim ,  Mark Stroud

IPC: A61K47/00 ,  A61K47/64 ,  A61K47/65 ,  A61P19/02 ,  A61P13/12 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00 ,  A61K49/00 ,  A61K51/08 ,  C07K14/435 ,  C07K14/47 ,  C07K16/24 ,  A61B5/055 ,  A61B8/08

Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

公开(公告)号：US11866466B2

公开(公告)日：2024-01-09

申请号：US16954190

申请日：2018-12-18

Applicant: BLAZE BIOSCIENCE, INC.

Inventor： Natalie Winblade Nairn ,  Julia Novak ,  Kenneth Grabstein ,  Dennis Miller ,  Greg T. Hermanson ,  Scott R. Presnell ,  Mark Stroud

IPC: A61K38/00 ,  C07K14/435 ,  A61K47/65 ,  A61K47/64 ,  A61P35/00 ,  A61K45/06 ,  C07K19/00

CPC classification number: C07K14/43522 ,  A61K45/06 ,  A61K47/64 ,  A61K47/65 ,  A61P35/00 ,  C07K19/00

Abstract: Peptide-immuno-oncology agent complexes (“peptide-I/O complexes”) that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.

公开(公告)号：US20210260205A1

公开(公告)日：2021-08-26

申请号：US17230353

申请日：2021-04-14

Applicant: Blaze Bioscience, Inc.

Inventor： Julia E. Novak ,  Natalie Winblade Nairn ,  Dennis M. Miller ,  Scott Presnell ,  Claudia Jochheim ,  Mark Stroud

IPC: A61K47/64 ,  A61K47/65 ,  A61P19/02 ,  A61P13/12 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00 ,  A61K49/00 ,  A61K51/08 ,  C07K14/435 ,  C07K14/47 ,  C07K16/24

Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

公开(公告)号：US20160096869A1

公开(公告)日：2016-04-07

申请号：US14855355

申请日：2015-09-15

Applicant: Blaze Bioscience, Inc.

Inventor： Stacey J. Hansen ,  Claudia Jochheim ,  Dennis M. Miller ,  Natalie Nairn ,  Julia E. Novak ,  Mark Stroud ,  Valorie R. Wiss ,  Kelly Byrnes-Blake

IPC: C07K14/435 ,  A61K49/00 ,  A61K47/48

CPC classification number: C07K14/43522 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/00 ,  A61K47/26 ,  A61K47/6415 ,  A61K49/0032 ,  A61K49/0056 ,  C12N9/96 ,  G01N33/5743

Abstract: Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided.

Abstract translation: 提供了包含蝎氯毒素偶联化合物的组合物，制剂和试剂盒，包括与包括荧光染料在内的报道分子缀合的蝎氯毒素肽的天然和修饰变体。 还提供了检测和治疗与蝎氯毒素偶联化合物的癌症和肿瘤的方法，包括成像肿瘤组织和细胞的方法。 还提供了使用氯毒素缀合化合物的治疗和诊断应用的给药和药代动力学特征。