公开(公告)号：US20200069812A1

公开(公告)日：2020-03-05

申请号：US16492914

申请日：2018-03-16

Applicant: BLAZE BIOSCIENCE, INC.

Inventor： Julia E. Novak ,  Natalie Winblade Naim ,  Dennis M. Miller ,  Scott Presnell ,  Claudia Jochheim ,  Mark Stroud

IPC: A61K47/64 ,  C07K16/24 ,  C07K14/435 ,  C07K14/47 ,  A61K49/00 ,  A61P19/02 ,  A61K51/08 ,  A61K47/65 ,  A61P13/12 ,  A61B5/00 ,  A61B6/03 ,  A61B6/00

Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.