公开(公告)号：US20220128547A1

公开(公告)日：2022-04-28

申请号：US17337274

申请日：2021-06-02

申请人： Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Ariz ,  Engineering Arts LLC

发明人： Peter Wiktor ,  Joshua Labaer ,  Peter Kahn ,  Bharath Takulapalli ,  Ji Qiu ,  Al Brunner ,  Mitch Magee

IPC分类号： G01N33/543 ,  B01J19/00 ,  C40B50/14 ,  C40B60/12 ,  G01N33/68 ,  C12N15/10

摘要： Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography.

公开(公告)号：US10128488B2

公开(公告)日：2018-11-13

申请号：US14768692

申请日：2014-02-27

申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Candace Chan

IPC分类号： H01M4/131 ,  H01M4/58 ,  H01M10/0525 ,  H01M10/054 ,  H01M4/485 ,  H01M4/02

摘要： An anode for a rechargeable battery includes a Type II clathrate having the formula MxX136, where a cage structure is formed by X, M represents one or more guest ions, and 0

公开(公告)号：US10078074B2

公开(公告)日：2018-09-18

申请号：US14761732

申请日：2014-01-21

申请人： Francis Tsow ,  Xiaojun Xian ,  Erica Forzani ,  Nongjian Tao ,  ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Francis Tsow ,  Xiaojun Xian ,  Erica Forzani ,  Nongjian Tao

IPC分类号： A61B5/083 ,  A61B5/0482 ,  A61B5/087 ,  G01N33/497 ,  A61B5/00 ,  A61B5/08

CPC分类号： G01N33/497 ,  A61B5/0482 ,  A61B5/0816 ,  A61B5/083 ,  A61B5/087 ,  A61B5/7405

摘要： A system for measuring and tracking metabolic rate, physical activity and calorie intake. The metabolic rate is measured with a design that features an adaptive sampling mechanism for accurate breath sample collection, optimized flow rate measurement for minimizing backpressure while maximizing accuracy, humidity regulation and water condensation reduction mechanism for reliable performance, as well as breath temperature measurement for volume and humidity corrections. The system further comprises an improved algorithm for determining physical activity such as related energy expenditure, and a mechanism for tracking changes in food intake over time.

公开(公告)号：US20180102766A1

公开(公告)日：2018-04-12

申请号：US15568858

申请日：2016-05-23

申请人： ARIZONA BOARD OF REGENTS, a Body Corporate of The State of Arizona, Acting for and on Behalf of ARIZ

发明人： Sarma Vrudhula ,  Niranjan Kulkarni

IPC分类号： H03K3/356 ,  G01R31/3177

CPC分类号： H03K3/356086 ,  G01R31/3177 ,  G01R31/318541 ,  H03K3/0375

摘要： A sequential state element (SSE) is disclosed. In one embodiment, an SSE includes a differential sense flip flop (DSFF) and a completion detection circuit (CDC) operably associated with the DSFF. The DSFF is configured to generate a differential logical output. During a normal operational mode, the DSFF is synchronized by a clock signal to provide a differential logical output in a differential output state in accordance with a data input or in a precharge state based on the clock signal. The differential logical output is provided in a differential output state in accordance with a test input during a scan mode. The CDC is configured to generate a test enable input during the scan mode that indicates the scan mode once the differential logical output is in the differential output state. Accordingly, another SSE can be asynchronously triggered to operate in the scan mode without a separate scan clock.

公开(公告)号：US09512212B2

公开(公告)日：2016-12-06

申请号：US14370199

申请日：2013-01-10

申请人： Arizona Board of Regents, a Body Corporate of the State of Arizona, Acting for and on Behalf of Arizona State University

发明人： Michael Sierks ,  Yong Shen

IPC分类号： G01N33/541 ,  G01N33/563 ,  G01N33/577 ,  C07K16/46 ,  C07K16/18 ,  C07K16/28 ,  C07K16/40 ,  C07K16/42 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/283 ,  C07K16/40 ,  C07K16/42 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/41

摘要： The present invention relates to therapeutic agents comprising bispecific recombinant antibody fragments to selectively clear a protein associated with a neurological disease and methods of use of these therapeutic agents to treat neurological diseases.

摘要翻译： 本发明涉及包含双特异性重组抗体片段的治疗剂，其选择性地清除与神经疾病相关的蛋白质以及使用这些治疗剂治疗神经疾病的方法。

公开(公告)号：US20160305855A1

公开(公告)日：2016-10-20

申请号：US15099121

申请日：2016-04-14

申请人： Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of

发明人： David Richardson ,  Thai Tran ,  Dmitry Derkach ,  Colleen Ziegler

IPC分类号： G01N1/28

CPC分类号： G01N1/286 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/0647 ,  B01L2300/0822 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/0688 ,  G01N2001/2886

摘要： Methods and apparatuses are provided for extraction and collection of sets of one or more cells from a formalin-fixed paraffin embedded tissue sample. A laser is used to remove sets of one or more cells from an immobilized sample within a microfluidic device, and a fluid flow element washes the removed set of one or more cells away from the immobilized sample, preferably to be collected in a downstream sample collection device. Morphological and/or positional information may be preserved to permit at least one technique (e.g., amplification, sequencing, and/or analytical, optionally performed after cells are lysed downstream of the microfluidic device) to be related to the original spatial location of the set of one or more cells in the immobilized sample.

摘要翻译： 提供了用于从福尔马林固定石蜡包埋的组织样品中提取和收集一组或多种细胞的方法和装置。 使用激光器从微流体装置内的固定化样品中去除一组或多种细胞组，并且流体流动元件将去除的一个或多个细胞组合从固定化样品中洗涤，优选收集在下游样品收集物 设备。 可以保留形态和/或位置信息以允许与组的原始空间位置相关的至少一种技术（例如，扩增，测序和/或分析，可选地在细胞裂解在微流体装置的下游之后进行） 的固定化样品中的一个或多个细胞。

公开(公告)号：US09234197B2

公开(公告)日：2016-01-12

申请号：US14349835

申请日：2012-10-26

申请人： ARIZONA BOARD OF REGENTS, a body corporate of the State of Arizona, acting for and on behalf of Ariz

发明人： John Chaput ,  Bertram Jacobs ,  Brian Wellensiek ,  Julia Flores

IPC分类号： C12N15/85 ,  C12N15/113 ,  C12N15/67 ,  C07H21/04 ,  C12N15/00 ,  C12N15/86 ,  C12N5/02 ,  C12P21/06

CPC分类号： C12N15/113 ,  C12N15/67 ,  C12N15/85 ,  C12N2830/30 ,  C12N2830/85 ,  C12N2840/105 ,  C12N2840/85

摘要： The present invention provides isolated polynucleotides that can serve as translation enhancing elements and their use in protein expression reagents and methods.

摘要翻译： 本发明提供可用作翻译增强元件的分离的多核苷酸及其在蛋白质表达试剂和方法中的用途。

公开(公告)号：US20150092806A1

公开(公告)日：2015-04-02

申请号：US14396344

申请日：2013-03-14

申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ,  ARIZONA STATE UNIVERSITY

发明人： Cun-Zheng Ning ,  Zhicheng Liu ,  Leijun Yin ,  Fan Fan ,  Hao Ning ,  Sunay Turdogan ,  Patricia L. Nichols

IPC分类号： C09K11/88 ,  H01S3/0941 ,  H01S3/16

CPC分类号： C09K11/88 ,  B82Y20/00 ,  H01L33/24 ,  H01S3/0941 ,  H01S3/169 ,  H01S5/021 ,  H01S5/041 ,  H01S5/10 ,  H01S5/101 ,  H01S5/1039 ,  H01S5/1042 ,  H01S5/327 ,  H01S5/4087 ,  H01S5/4093 ,  Y02B20/181 ,  Y10S977/951

摘要： Described herein are multi-segmented nanowires, nanosheets and nanobelts, and devices and methods using them for the generation of multicolor and white light.

摘要翻译： 这里描述的是多分段纳米线，纳米片和纳米带，以及使用它们用于产生多色和白光的装置和方法。

公开(公告)号：US20150057513A1

公开(公告)日：2015-02-26

申请号：US14378454

申请日：2013-03-08

申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF AR

发明人： Jeffrey LaBelle ,  Katherine Ruh ,  Brittney Haselwood

IPC分类号： A61B5/16 ,  A61B5/00 ,  A61B5/1473

CPC分类号： A61B5/165 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/412 ,  A61B5/4884 ,  A61B5/685

摘要： Methods and devices to continuously measure electrochemical activity of one or more biochemical or molecular markers (FIG. 9). A substrate having electronics for measuring electrochemical activity and a plurality of electrodes such that the electrodes are in contact with the subcutaneous layer are attached to subject's skin or intravenously. The devices measure a biochemical process associated with one or more biochemical or molecular markers in vivo by detecting an electrochemical signal in subcutaneous layer (or intravenously) using the plurality of electrodes.

摘要翻译： 连续测量一种或多种生物化学或分子标记物的电化学活性的方法和装置（图9）。 具有用于测量电化学活性的电子学的基板和使得电极与皮下层接触的多个电极附接到受试者的皮肤或静脉内。 该装置通过使用多个电极检测皮下层（或静脉内）的电化学信号来测量与体内一种或多种生物化学或分子标记物相关的生化过程。

公开(公告)号：US20150040228A1

公开(公告)日：2015-02-05

申请号：US13955552

申请日：2013-07-31

申请人： ARIZONA BOARD OF REGENTS, a body corporate of the State of Arizona, acting for and on behalf of Ariz ,  Hewlett-Packard Development Company, L.P.

发明人： Jung Gun Lee ,  Chun-Jen Chung ,  Pankaj Kumar Khatkar ,  Tianyi Xing ,  Dijiang Huang

IPC分类号： H04L29/06

CPC分类号： H04L63/1433 ,  H04L63/1408 ,  H04L63/1441

摘要： Examples disclose a method, executable by a processor, to assign a metric of vulnerability to a virtual machine. Based on the metric of vulnerability, the method places the virtual machine into a detection phase. Additionally, the examples disclose the method is to receive an alert corresponding to the virtual machine and based this received alert, the method implements a countermeasure.

摘要翻译： 示例公开了一种可由处理器执行的方法，以将漏洞的度量指定给虚拟机。 基于漏洞的度量，该方法将虚拟机置于检测阶段。 此外，这些示例公开了该方法是接收与虚拟机相对应的警报并且基于该接收的警报，该方法实施对策。