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公开(公告)号：US10241011B2
公开(公告)日：2019-03-26
申请号：US15646701
申请日：2017-07-11
发明人： Bridget Carragher , Clinton S. Potter , Tilak Jain , Peter Kahn , Peter Wiktor
摘要： The invention provides methods and devices for preparing frozen vitrified samples for transmission electron microscopy. By reducing the volume of sample from microliter scale to picoliter scale, the requirement for blotting of excess fluid is minimized or eliminated.
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公开(公告)号：US20140371091A1
公开(公告)日：2014-12-18
申请号：US14345032
申请日：2012-10-24
申请人： Arizona Board of Regents, a body corporate of the state of Arizona, acting for and on behalf of , Engineering Arts LLC
发明人： Peter Wiktor , Joshua Labaer , Peter Kahn , Bharath Takulapalli , Ji Qiu , Al Brunner , Mitch Magee
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00317 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C12N15/1079 , C40B50/14 , C40B60/12 , G01N33/6845
摘要： Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography.
摘要翻译： 描述了在多个离散的，隔离的位置上含有多个生物分子，例如编码核酸和/或分离的多肽的底物上的生物分子阵列。 阵列可用于例如用于特定用途的高通量基因组学和蛋白质组学，包括但不限于用于早期检测，诊断，治疗，预后，监测临床反应和蛋白质晶体学的分子诊断。
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公开(公告)号：US20140360286A1
公开(公告)日：2014-12-11
申请号：US14372277
申请日：2013-01-14
发明人： Bridget Carragher , Clinton S. Potter , Tilak Jain , Peter Kahn , Peter Wiktor
CPC分类号： G01N1/28 , G01N1/2813 , G01N1/42 , H01J37/26 , H01J37/261 , H01J2237/2001 , H01J2237/2802
摘要： The invention provides methods and devices for preparing frozen vitrified samples for transmission electron microscopy. By reducing the volume of sample from microliter scale to picoliter scale, the requirement for blotting of excess fluid is minimized or eliminated.
摘要翻译： 本发明提供用于制备用于透射电子显微镜的冷冻玻璃化样品的方法和装置。 通过将样品从微升级的体积减小到皮升级，可以将过量流体的印迹要求降至最低或消除。
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公开(公告)号：US20180267029A1
公开(公告)日：2018-09-20
申请号：US15938575
申请日：2018-03-28
申请人： Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Ariz , Engineering Arts LLC
发明人： Peter Wiktor , Joshua Labaer , Peter Kahn , Bharath Takulapalli , Ji Qiu , Al Brunner , Mitch Magee
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00317 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C12N15/1079 , C40B50/14 , C40B60/12 , G01N33/6845
摘要： Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography.
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公开(公告)号：US20220128547A1
公开(公告)日：2022-04-28
申请号：US17337274
申请日：2021-06-02
申请人： Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Ariz , Engineering Arts LLC
发明人： Peter Wiktor , Joshua Labaer , Peter Kahn , Bharath Takulapalli , Ji Qiu , Al Brunner , Mitch Magee
摘要： Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography.
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公开(公告)号：US09702795B2
公开(公告)日：2017-07-11
申请号：US14372277
申请日：2013-01-14
申请人： THE SCRIPPS RESEARCH INSTITUTE , ENGINEERING ARTS LLC , Bridget Carragher , Clinton S. Potter , Tilak Jain , Peter Kahn , Peter Wiktor
发明人： Bridget Carragher , Clinton S. Potter , Tilak Jain , Peter Kahn , Peter Wiktor
CPC分类号： G01N1/28 , G01N1/2813 , G01N1/42 , H01J37/26 , H01J37/261 , H01J2237/2001 , H01J2237/2802
摘要： The invention provides methods and devices for preparing frozen vitrified samples for transmission electron microscopy. By reducing the volume of sample from microliter scale to picoliter scale, the requirement for blotting of excess fluid is minimized or eliminated.
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