公开(公告)号：US20180161379A1

公开(公告)日：2018-06-14

申请号：US15865220

申请日：2018-01-08

申请人： MICROVASCULAR TISSUES, INC.

发明人： Dale R. PETERSON ,  Ralph-Heiko MATTERN ,  Corey WILSON ,  Kevin L. OHASHI ,  Lael J. PICKETT ,  Glen GONG ,  Mohammad A. EL-KALAY

IPC分类号： A61K35/44 ,  A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61K35/12 ,  C12N5/077

CPC分类号： A61K35/44 ,  A61K35/12 ,  A61K35/545 ,  A61L27/3625 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/10 ,  A61L2430/32 ,  A61L2430/34 ,  A61L2430/38 ,  C12N5/0653

摘要： The present invention provides novel compositions comprising multipotent cells or microvascular tissue, wherein the cells or tissue has been sterilized and/or treated to inactivated viruses, and related methods of using these compositions to treat or prevent tissue injury or disease in an allogeneic subject.

公开(公告)号：US09993576B2

公开(公告)日：2018-06-12

申请号：US15670284

申请日：2017-08-07

申请人： Pioneer Surgical Technology, Inc.

发明人： Juchui Ray Lin ,  Edward S. Ahn ,  Brian M. Schlossberg

IPC分类号： A61L24/06 ,  A61K6/083 ,  A61K6/08 ,  A61L24/04 ,  A61L24/02 ,  A61K6/033

CPC分类号： A61L24/06 ,  A61K6/033 ,  A61K6/08 ,  A61K6/083 ,  A61L24/02 ,  A61L24/04 ,  A61L24/046 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/12

摘要： Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.

公开(公告)号：US20180155378A1

公开(公告)日：2018-06-07

申请号：US15576531

申请日：2016-05-26

申请人： Monash University

发明人： Philip Andrews ,  Melissa Werrett ,  Madleen Busse

IPC分类号： C07F9/94 ,  A01N57/22 ,  A61K31/663 ,  A61K31/662 ,  A61L15/20 ,  A61L15/44 ,  A61L17/00 ,  A61L31/16 ,  A61L31/08 ,  A61L24/00 ,  A61K6/00 ,  C09D5/14

CPC分类号： C07F9/94 ,  A01N57/22 ,  A61K6/0067 ,  A61K31/662 ,  A61K31/663 ,  A61K33/245 ,  A61K33/42 ,  A61L15/20 ,  A61L15/44 ,  A61L17/005 ,  A61L24/0015 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/404 ,  A61L2430/02 ,  C09D5/14

摘要： Provided herein are organobismuth (III) phosphinate complexes, which comprise a phosphinate group and an aromatic carbocyclyl or aromatic heterocyclyl group. The complexes find use as antibacterial agents, and accordingly also provided herein are products, devices, compositions and materials comprising the complexes, for example medical products such as wound dressings and bandages.

公开(公告)号：US20180154046A1

公开(公告)日：2018-06-07

申请号：US15872667

申请日：2018-01-16

申请人： Scripps Health

发明人： Darryl D. D'LIMA ,  Tsaiwei OLEE ,  Clifford W. COLWELL

IPC分类号： A61L27/44 ,  A61L27/38 ,  A61L27/54 ,  C08L5/08 ,  A61L27/26 ,  C08L89/06

CPC分类号： A61L27/44 ,  A61L27/26 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/54 ,  A61L2300/412 ,  A61L2300/64 ,  A61L2430/02 ,  A61L2430/06 ,  C08L5/08 ,  C08L89/06

摘要： Provided are tri-component matrices having collagen, hyaluronan, and chondroitin sulfate. Also provided are processes for producing a tri-component matrix. Additionally, provided are processes for providing cells capable of producing cartilage to a bone or cartilage defects.

公开(公告)号：US20180126034A1

公开(公告)日：2018-05-10

申请号：US15843946

申请日：2017-12-15

申请人： Jessica A. Ching ,  Jonathan Michael Ford ,  Summer Joy Decker

发明人： Jessica A. Ching ,  Jonathan Michael Ford ,  Summer Joy Decker

IPC分类号： A61L27/26 ,  A61L27/36 ,  A61L27/56 ,  A61L27/54 ,  A61F2/28

CPC分类号： A61L27/26 ,  A61F2/2846 ,  A61L27/18 ,  A61L27/3608 ,  A61L27/3645 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2430/02 ,  A61L2430/12 ,  A61L2430/38 ,  C08L67/04

摘要： Aspects of the present invention provide implants for augmentation, stabilization, or defect reconstruction of bone tissue, comprising a scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following: one or more polylactic acid isomer; one or more polyglycolic acid isomer; and/or allogenic bone material, or similar compound.

公开(公告)号：US20180116700A1

公开(公告)日：2018-05-03

申请号：US15800459

申请日：2017-11-01

申请人： KLS-Martin, L.P.

发明人： Thomas S. Johnston, JR. ,  Jennifer Pinto ,  Klaus Kohler

IPC分类号： A61B17/80

CPC分类号： A61B17/8061 ,  A61B17/688 ,  A61B17/80 ,  A61B17/8085 ,  A61B90/06 ,  A61B2017/564 ,  A61B2090/061 ,  A61L2430/02

摘要： One or more arrays of flexible, disposable, bone plate sizers with corresponding arrays of permanent bone plates, systems using these bone plate sizers and/or templates, and methodologies using these bone plate sizers and/or templates are embodied. Each array of disposable bone plate sizers has a plurality of sizers having differing configurations and sizes, each of the disposable sizers in a given array corresponding to a particular bone screw size. Each of the disposable bone plate sizers in a given array are mounted upon and easily detachable from a frame member. The disposable bone plate sizers may be malleable such that may be manipulated by the surgeon into the desired three-dimensional shape to match the contour of the bone segments to be joined, thereby providing a template to shape the corresponding permanent bone plate.

公开(公告)号：US20180110904A1

公开(公告)日：2018-04-26

申请号：US15561861

申请日：2015-11-06

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Savio L-Y Woo ,  Kwang E. Kim ,  Jonquil R. Flowers

IPC分类号： A61L31/02 ,  A61L31/14 ,  A61B17/04

CPC分类号： A61L31/022 ,  A61B17/0401 ,  A61B2017/00004 ,  A61B2017/00893 ,  A61B2017/00911 ,  A61B2017/0414 ,  A61B2017/044 ,  A61L31/148 ,  A61L31/18 ,  A61L2430/02

摘要： A suture anchor apparatus comprising: an anchoring member made from a metal-based material and comprising a generally elongated body having a proximal end and a distal end, wherein an outer surface of the anchoring member defines a threading that winds around the body in a plurality of turns disposed along a longitudinal axis of the body; wherein the threading has a depth of about 1 mm and a pitch of about 3 mm, and an eyelet disposed near the distal end and penetrating transversely through the body.

公开(公告)号：US09949832B2

公开(公告)日：2018-04-24

申请号：US15048170

申请日：2016-02-19

申请人： Warsaw Orthopedic, Inc.

发明人： William F. McKay

IPC分类号： A61F2/28 ,  A61L27/36 ,  A61L27/50 ,  A61F2/30

CPC分类号： A61F2/28 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/30059 ,  A61F2002/30261 ,  A61F2230/0069 ,  A61F2310/00179 ,  A61F2310/00359 ,  A61F2310/00371 ,  A61L27/3608 ,  A61L27/50 ,  A61L2430/02

摘要： Bone implant compositions are provided that include a body made of cortical bone extending along an axis between a first end and a second end. The body includes an outer surface configured to engage host bone of a patient and at least one recess extending transverse to the axis into the outer surface of the body configured for disposal of an insert. At least one insert made of demineralized bone is disposed in the at least one recess.

公开(公告)号：US20180104382A1

公开(公告)日：2018-04-19

申请号：US15841685

申请日：2017-12-14

申请人： Biomet Manufacturing, LLC

发明人： Jennifer E. Woodell-May ,  Karen S. Troxel

IPC分类号： A61L27/36 ,  A61L31/14 ,  A61L31/12 ,  A61L31/10 ,  A61L31/00 ,  A61L27/58 ,  A61L27/56 ,  A61L27/54 ,  A61L27/12 ,  A61L27/06 ,  A61L27/04 ,  C08L89/06

CPC分类号： A61L27/3608 ,  A61L27/042 ,  A61L27/045 ,  A61L27/047 ,  A61L27/06 ,  A61L27/12 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/10 ,  A61L31/124 ,  A61L31/146 ,  A61L2300/30 ,  A61L2300/414 ,  A61L2300/606 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2430/02 ,  C08L89/06

摘要： A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.

公开(公告)号：US09943626B2

公开(公告)日：2018-04-17

申请号：US15082187

申请日：2016-03-28

申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

发明人： Daniel S. Oh

IPC分类号： A61L27/58 ,  A61L27/56 ,  A61F2/28 ,  A61L27/12 ,  A61L27/54 ,  A61L27/26

CPC分类号： A61L27/56 ,  A61F2/28 ,  A61F2002/2817 ,  A61L27/12 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2430/02

摘要： A granule form e d from a tubular body having an outer surface and an inner surface separated by a matrix, and at least one core defining an opening extending through the tubular body. The outer surface of the matrix is adapted to permit fluid flow into and out of the matrix.