公开(公告)号：US20230233280A1

公开(公告)日：2023-07-27

申请号：US18069620

申请日：2022-12-21

申请人： Scripps Health

发明人： Clifford W. Colwell, JR. ,  Darryl David D'Lima

IPC分类号： A61B90/00 ,  A61B5/103 ,  A61B5/107 ,  A61B5/00 ,  A61F2/46 ,  A61B34/20 ,  A61B34/00 ,  A61B17/16

CPC分类号： A61B90/06 ,  A61B5/1036 ,  A61B5/1076 ,  A61B5/4528 ,  A61B5/4585 ,  A61F2/461 ,  A61B5/103 ,  A61B34/20 ,  A61B34/25 ,  A61F2/4657 ,  A61B17/1664 ,  A61B17/1671 ,  A61B17/1675 ,  A61B17/1682 ,  A61B17/1684 ,  A61B17/1686 ,  A61B2090/065 ,  A61F2/38

摘要： A joint replacement balancing system which provides real-time feedback to a surgeon during a joint replacement surgery to assist the surgeon to balance a joint replacement. The joint replacement balancing system includes a non-transitory processor-readable medium storing code representing instructions to cause a processor to receive a signal from a joint balancing apparatus, determine if the joint replacement is out of balance, determine a corrective course of action to bring the joint into balance and generate and display to the surgeon during the joint replacement surgery a recommended corrective course of action to complete the joint replacement surgery.

公开(公告)号：US20210231659A1

公开(公告)日：2021-07-29

申请号：US17165718

申请日：2021-02-02

申请人： Scripps Health ,  The Scripps Research Institute

发明人： Darren SIGAL ,  Matthew MACAULEY

IPC分类号： G01N33/569 ,  G01N33/574

摘要： Myeloid derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells with the ability to mediate immunosuppression in cancer. Disclosed herein are methods of identifying MDSCs, methods of isolating MDSCs, and methods of treating patients.

公开(公告)号：US20210187111A1

公开(公告)日：2021-06-24

申请号：US17150703

申请日：2021-01-15

申请人： Scripps Health

发明人： Faith BARNETT ,  Mauricio ROSENFELD

IPC分类号： A61K47/54 ,  A61K45/06 ,  A61P35/00 ,  A61K47/64 ,  A61K47/61

摘要： Described herein are methods and compositions for disrupting a macrophage network. Described herein are targeting agents capable of targeting one or more cells of a macrophage network. Methods for treating various diseases, such as cancer and granulomatous diseases are provided.

公开(公告)号：US20170007741A1

公开(公告)日：2017-01-12

申请号：US15125749

申请日：2015-03-13

申请人： SCRIPPS HEALTH

发明人： Darryl D'LIMA ,  Shawn GROGAN ,  Clifford COLWELL

IPC分类号： A61L27/26 ,  A61F2/38 ,  A61L27/24 ,  A61L27/18 ,  D01D5/34 ,  A61L27/54 ,  A61L27/38 ,  A61L27/58 ,  D01D5/00 ,  A61F2/30 ,  A61L27/20

CPC分类号： A61L27/26 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/3872 ,  A61F2002/4495 ,  A61F2210/0004 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3817 ,  A61L27/3826 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/06 ,  D01D5/0038 ,  D01D5/34 ,  D10B2331/041 ,  D10B2401/12 ,  D10B2509/00 ,  C08L5/08 ,  C08L5/04

摘要： Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.

摘要翻译： 本文公开了通过将聚合物溶液电纺丝到收集器上以获得聚合物纤维来生产聚合物支架组合物来生产软骨植入物的方法; 交联聚合物纤维; 以及将多个细胞添加到所述聚合物支架组合物中，其中所述多个细胞包含软骨细胞以形成软骨植入物。

公开(公告)号：US20150361496A1

公开(公告)日：2015-12-17

申请号：US14714063

申请日：2015-05-15

申请人： Scripps Health ,  Janssen Diagnostics, LLC ,  Ortho-Clinical Diagnostics, Inc.

发明人： Eric J. TOPOL ,  Evan MUSE ,  Mark CONNELLY ,  Timothy JATKOE ,  Haiying WANG

IPC分类号： C12Q1/68 ,  G06F19/20

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G06F19/20

摘要： Compositions, systems and methods for the diagnosing the risk of acute myocardial infarction are provided. The methods described herein relate to the use of biomarkers, such as gene expression profiles, and analytical tools for providing information to a health care provider or the patient, that is relevant to the cardiovascular health of the patient.

摘要翻译： 提供了用于诊断急性心肌梗死风险的组合物，系统和方法。 本文描述的方法涉及生物标志物的使用，例如基因表达谱，以及用于向医疗保健提供者或患者提供与患者的心血管健康相关的信息的分析工具。

公开(公告)号：US20150275181A1

公开(公告)日：2015-10-01

申请号：US14438581

申请日：2013-10-29

申请人： SCRIPPS HEALTH

发明人： Darryl D. D'Lima ,  Tsaiwei Olee ,  Clifford W. Colwell

IPC分类号： C12N5/074 ,  A61K35/32

CPC分类号： C12N5/0696 ,  A61K35/32 ,  A61K35/545 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2506/13 ,  C12N2510/00 ,  C12N2513/00 ,  C12N2533/54

摘要： Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells. The invention further provides methods of regenerating cartilaginous tissue.

摘要翻译： 本文公开了从软骨细胞产生诱导性多能干细胞的方法，以及从所述诱导的多能干细胞产生软骨细胞的方法。 本发明还提供了再生软骨组织的方法。

公开(公告)号：US20230148084A1

公开(公告)日：2023-05-11

申请号：US17945575

申请日：2022-09-15

申请人： SCRIPPS HEALTH

发明人： Darryl D. D'LIMA ,  Shawn GROGAN ,  Clifford W. COLWELL, JR. ,  Jihye BAEK

IPC分类号： A61L27/26 ,  A61F2/38 ,  A61F2/30 ,  A61L27/20 ,  A61L27/24 ,  A61L27/54 ,  A61L27/52 ,  A61L27/50 ,  A61L27/38 ,  A61L27/18 ,  A61L27/58 ,  D01D5/00 ,  D01D5/34

CPC分类号： A61L27/26 ,  A61F2/3872 ,  A61F2/30756 ,  A61F2/3094 ,  A61L27/20 ,  A61L27/24 ,  A61L27/54 ,  A61L27/52 ,  A61L27/50 ,  A61L27/3817 ,  A61L27/3834 ,  A61L27/18 ,  A61L27/3826 ,  A61L27/58 ,  D01D5/0038 ,  D01D5/34 ,  A61F2002/4495

摘要： Disclosed herein are methods of producing a cartilaginous implant by producing a polymer scaffold composition by electrospinning a polymer solution onto a collector in order to obtain polymer fibers; crosslinking the polymer fibers; and adding a plurality of cells to the polymer scaffold composition, wherein the plurality of cells comprises cartilaginous cells to form a cartilaginous implant.

公开(公告)号：US11540895B2

公开(公告)日：2023-01-03

申请号：US16456270

申请日：2019-06-28

申请人： Scripps Health

发明人： Clifford W. Colwell, Jr. ,  Darryl David D'Lima

IPC分类号： A61F2/46 ,  A61B90/00 ,  A61B5/103 ,  A61B5/107 ,  A61B5/00 ,  A61B34/20 ,  A61B34/00 ,  A61B17/16 ,  A61F2/38

摘要： A joint replacement balancing system which provides real-time feedback to a surgeon during a joint replacement surgery to assist the surgeon to balance a joint replacement. The joint replacement balancing system includes a non-transitory processor-readable medium storing code representing instructions to cause a processor to receive a signal from a joint balancing apparatus, determine if the joint replacement is out of balance, determine a corrective course of action to bring the joint into balance and generate and display to the surgeon during the joint replacement surgery a recommended corrective course of action to complete the joint replacement surgery.

公开(公告)号：US20220331086A1

公开(公告)日：2022-10-20

申请号：US17751106

申请日：2022-05-23

申请人： Scripps Health

发明人： Darryl D. D'LIMA ,  Clifford COLWELL

IPC分类号： A61F2/02 ,  A61K47/14 ,  A61F2/06 ,  A61K35/32 ,  A61K35/33 ,  C12M1/26 ,  C12M3/00

摘要： Disclosed herein are methods of printing a bio-ink on a substrate. The methods further encompass methods of printing a live tissue and methods of treating tissue defects.

公开(公告)号：US10180422B1

公开(公告)日：2019-01-15

申请号：US15683630

申请日：2017-08-22

申请人： Scripps Health

发明人： Darren Sigal

IPC分类号： G01N33/50 ,  C12Q1/6886 ,  G01N33/574

摘要： Disclosed herein, are methods of treating a neuroendocrine tumor (NET) in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of an agent that inhibits a tropomyosin receptor kinase (Trk) protein, wherein the NET is associated with a Trk protein that has undergone a genetic translocation or is an NTRK gene fusion protein. Also disclosed herein are methods of treating a neuroendocrine tumor (NET) in an individual in need thereof, comprising: (a) obtaining a sample of NET genetic material from the individual; (b) determining whether the NET tumor comprises a NTRK translocation or gene fusion; and (c) administering to the individual a therapeutically effective amount of an agent that inhibits a tropomyosin receptor kinase (Trk) protein.