公开(公告)号：US06491657B2

公开(公告)日：2002-12-10

申请号：US09861924

申请日：2001-05-21

申请人： Stephen Rowe ,  Joseph Kost ,  Samir S. Mitragotri ,  Michael Pishko ,  Matthew Davis

发明人： Stephen Rowe ,  Joseph Kost ,  Samir S. Mitragotri ,  Michael Pishko ,  Matthew Davis

IPC分类号： A61B1720

CPC分类号： A61B5/14514 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150137 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15136 ,  A61M37/0092 ,  A61M2037/0007

摘要： Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while causing less pain. Alternatively, ultrasound energy is applied through a vibrating element positioned just contacting, above or extending into the skin. Use of the element facilitates extraction of analyte and may enhance drug delivery. A two step noninvasive method involves application of ultrasound to increase skin permeability and removal of ultrasound followed by transdermal transport that can be further enhanced using a physical enhancer.

摘要翻译： 将超声应用于小面积皮肤以增强透皮运输的方法和装置。 具有第一焦距的超声波束被引导到具有第二较小直径的光束中，而实质上没有能量损失。 可以使用更高能量的超声波，同时减少疼痛。 或者，通过刚刚接触皮肤上方或延伸到皮肤的振动元件施加超声能量。 元素的使用有助于提取分析物，并且可以增强药物递送。 两步非侵入性方法涉及应用超声波以增加皮肤渗透性和去除超声，然后进行透皮转运，其可以使用物理增强剂进一步增强。

公开(公告)号：US20020138049A1

公开(公告)日：2002-09-26

申请号：US10010723

申请日：2001-12-06

发明人： Mark G. Allen ,  Mark R. Prausnitz ,  Devin V. McAllister ,  Florent Paul Marcel Cros

IPC分类号： B29C033/40

CPC分类号： B81C1/00111 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  A61B17/205 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  A61N1/303 ,  B81B2201/055

摘要： Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

公开(公告)号：US20020136863A1

公开(公告)日：2002-09-26

申请号：US09817567

申请日：2001-03-26

发明人： Kumar Subramanian ,  Wilson Smart ,  Eugene Orloff

IPC分类号： B32B003/00

CPC分类号： A61B5/14514 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150984 ,  Y10T428/24479 ,  Y10T428/24802

摘要： A minimally intrusive, self-use microlancet device is provided. The microlancet device is capable of piercing a patient's skin reliably and virtually painlessly for obtaining a blood sample. The microlancet device comprises a silicon wafer formed into a sharp probe for piercing the patient's skin. Also provided is a fabrication method for the microlancet device.

摘要翻译： 提供了一种微创侵入式自我使用的微分针装置。 微量针刺装置能够可靠地且无痛地刺穿患者的皮肤以获得血液样本。 微量滴定装置包括形成为用于刺穿患者皮肤的尖锐探针的硅晶片。 还提供了一种微量针刺装置的制造方法。

公开(公告)号：US06440096B1

公开(公告)日：2002-08-27

申请号：US09616771

申请日：2000-07-14

申请人： Alexander G. Lastovich ,  John D. Evans ,  Ronald J. Pettis

发明人： Alexander G. Lastovich ,  John D. Evans ,  Ronald J. Pettis

IPC分类号： A61N130

CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150984 ,  A61B5/15142 ,  A61B17/205 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038

摘要： A device for monitoring, sampling or delivering a substance though the skin of a patient includes a support and a microdevice having at least one skin penetrating member. The support has a substantially flat bottom surface with the skin penetrating member extending beyond the bottom surface. An outlet port extends through the support to the bottom surface at a location between the skin penetrating member and the outer edge of the support for drawing a vacuum to enhance penetration of the skin. The device is produced by positioning the microdevice in a recess formed in the support and applying a bonding agent to wick into a gap formed between the microdevice and the wall of the recess.

公开(公告)号：US20240238569A1

公开(公告)日：2024-07-18

申请号：US18239752

申请日：2023-08-29

申请人： One Drop Biosensor Technologies, LLC

发明人： Ashwin Pushpala ,  Alan Szmodis ,  Matthew Chapman ,  Weldon Hall ,  Scott Miller ,  Hooman Hafezi

IPC分类号： A61M37/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/15 ,  A61M25/00 ,  C12Q1/00 ,  G01N27/327

CPC分类号： A61M37/0015 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/4839 ,  A61B5/685 ,  C12Q1/006 ,  G01N27/3271 ,  A61B2562/028 ,  A61B2562/12 ,  A61B2562/125 ,  A61M25/00 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  Y10T29/49117

摘要： A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

公开(公告)号：US11896792B2

公开(公告)日：2024-02-13

申请号：US16722977

申请日：2019-12-20

申请人： ONE DROP BIOSENSOR TECHNOLOGIES, LLC

发明人： Ashwin Pushpala ,  Alan Szmodis ,  Matthew Chapman ,  Weldon Hall ,  Scott Miller ,  Hooman Hafezi

IPC分类号： A61B5/05 ,  A61M37/00 ,  G01N27/327 ,  A61B5/15 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/00 ,  A61M25/00

CPC分类号： A61M37/0015 ,  A61B5/1495 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/4839 ,  A61B5/685 ,  C12Q1/006 ,  G01N27/3271 ,  A61B2562/028 ,  A61B2562/12 ,  A61B2562/125 ,  A61M25/00 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  Y10T29/49117

摘要： A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

公开(公告)号：US20230338639A1

公开(公告)日：2023-10-26

申请号：US18333656

申请日：2023-06-13

申请人： YourBio Health, Inc.

发明人： Howard Bernstein ,  Donald E. Chickering, III ,  Ping Gong ,  Shawn Davis

IPC分类号： A61M5/00 ,  A61M1/38 ,  A61B5/15 ,  A61B5/151 ,  A61M37/00

CPC分类号： A61M5/00 ,  A61M1/38 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150412 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15188 ,  A61M37/0015 ,  A61M2037/0023

摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. The flow activator may be actuated in a deployment direction by a deployment actuator, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, an effector may enable fluid communication between the opening and the vacuum source and may do so in response to actuation of the flow activator.

公开(公告)号：US20190209820A1

公开(公告)日：2019-07-11

申请号：US16048722

申请日：2018-07-30

申请人： Seventh Sense Biosystems, Inc.

发明人： Donald E. Chickering, III ,  Douglas A. Levinson ,  Shawn Davis ,  Ramin Haghgooie ,  Howard Bernstein ,  David R. Walt

IPC分类号： A61M37/00 ,  A61B5/15 ,  A61B5/145 ,  A61B5/00 ,  A61M5/142 ,  A61N1/32 ,  A61B90/96 ,  A61B90/98

CPC分类号： A61M37/0015 ,  A61B5/117 ,  A61B5/14514 ,  A61B5/150984 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B90/96 ,  A61B90/98 ,  A61B2560/0412 ,  A61M5/14248 ,  A61M37/00 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/3576 ,  A61M2205/6009 ,  A61M2205/6072 ,  A61N1/30 ,  A61N1/325

摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.

公开(公告)号：US20180214059A1

公开(公告)日：2018-08-02

申请号：US15826418

申请日：2017-11-29

申请人： Intuity Medical, Inc.

发明人： Raul ESCUTIA ,  Craig M. LITHERLAND ,  Jeffrey L. EMERY ,  Jeffrey M. JONES ,  Michael F. TOMASCO ,  Kelley J. LIPMAN

IPC分类号： A61B5/15 ,  A61B5/157 ,  A61B5/151

CPC分类号： A61B5/150832 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150091 ,  A61B5/150099 ,  A61B5/150183 ,  A61B5/150229 ,  A61B5/150259 ,  A61B5/150267 ,  A61B5/150274 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150748 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/150954 ,  A61B5/150984 ,  A61B5/15107 ,  A61B5/15109 ,  A61B5/15117 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/157 ,  A61M5/422

摘要： An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site includes: a housing, the housing comprising a first opening; a skin interface member disposed in the first opening, the skin interface member comprising an inner member having a second opening, and an outer member at least partially surrounding the inner member and attached to the first opening; and at least one skin-penetration member configured and arranged to project within the second opening. Arrangements having alternatively constructed skin interface members are also described.

公开(公告)号：US10034636B2

公开(公告)日：2018-07-31

申请号：US14269080

申请日：2014-05-03

申请人： Micro Nipple Technology Co., Ltd.

发明人： Juang-Tang Huang

IPC分类号： A61B5/05 ,  A61B5/00 ,  A61B5/1473 ,  B32B37/24 ,  A61B5/145 ,  A61B5/15

CPC分类号： A61B5/685 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/6833 ,  A61B2562/046 ,  A61B2562/125 ,  B32B37/24 ,  B32B2037/243 ,  B32B2535/00 ,  Y10T156/10

摘要： The invention relates to a transdermal microneedle array patch for measuring a concentration of a hypodermal target molecule. The transdermal microneedle array patch includes a substrate, a microneedle unit, a signal processing unit and a power supply unit. The microneedle unit at least comprises a first microneedle set used as a working electrode and a second microneedle set used as a reference electrode, the first and second microneedle sets arranging on the substrate. Each microneedle set comprises at least a microneedle. The first microneedle set comprises at least a sheet having a through hole on which a barbule forms at the edge. One of the sheet provides the through hole from which the barbules at the edge of the other sheets go through, and the barbules are disposed separately.