公开(公告)号：US611014A

公开(公告)日：1898-09-20

申请号：US611014D

CPC分类号： C07C59/70

公开(公告)号：US20190248725A1

公开(公告)日：2019-08-15

申请号：US16397139

申请日：2019-04-29

申请人： CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.

发明人： Imre JUHÁSZ ,  Irén HORTOBÁGYI ,  Tamás ALTSACH ,  István LÁSZLÓFI ,  Ágnes NAGYNÉ BORKÓ ,  Imre ROZSUMBERSZKI ,  Gábor HAVASI ,  Zsuzsanna KARDOS ,  Péter BUZDER-LANTOS

IPC分类号： C07C51/347 ,  C07C59/72 ,  C07C67/14 ,  C07C13/547 ,  C07C35/37 ,  C07C51/41 ,  C07C51/09 ,  C07C45/65 ,  C07C45/30 ,  C07C41/26 ,  C07C43/315 ,  C07C41/48 ,  C07C41/30 ,  C07C69/76 ,  C07C67/293 ,  C07C67/29

CPC分类号： C07C51/347 ,  C07C13/547 ,  C07C35/37 ,  C07C41/26 ,  C07C41/30 ,  C07C41/48 ,  C07C43/315 ,  C07C45/30 ,  C07C45/305 ,  C07C45/65 ,  C07C51/09 ,  C07C51/412 ,  C07C59/72 ,  C07C67/14 ,  C07C67/29 ,  C07C67/293 ,  C07C69/76 ,  C07C2603/14 ,  C07C49/84 ,  C07C49/755 ,  C07C59/70

摘要： Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.

公开(公告)号：US20180303092A1

公开(公告)日：2018-10-25

申请号：US15957008

申请日：2018-04-19

申请人： Taminco BVBA

发明人： Karen Mollet ,  Michael Schmidt ,  Kristof Moonen ,  Peter Roose ,  Jim Van Durme

IPC分类号： A01N39/04 ,  C07C215/08 ,  C07C65/21 ,  C07C211/11 ,  C07C59/70 ,  C07C211/07 ,  C07C209/68 ,  C07C51/41 ,  C07C213/08 ,  A01N37/40 ,  A01N25/02

CPC分类号： A01N39/04 ,  A01N25/02 ,  A01N37/40 ,  C07C51/412 ,  C07C59/70 ,  C07C65/21 ,  C07C209/68 ,  C07C211/07 ,  C07C211/11 ,  C07C213/08 ,  C07C215/08

摘要： The invention generally involves combining specialty amines with herbicidal carboxylic acids to form a new generation of salts with improved characteristics. The salts contain a cation of an amine and an anion of a carboxylic acid herbicide. The amine is advantageously selected from mono-isobutylamine (MIBA), N-methylaminoethanol (MMEA), dimethylaminopropylamine (DMAPA), 2-dimethylaminoethanol (DMAE), methyldiethanolamine (MDEA), and 1,2-diaminopropane (1,2-DAP). The amine-herbicide combinations may possess one or more improved characteristics, including maximum loading, wettability, drift, viscosity, and volatilization.

公开(公告)号：US20180303091A1

公开(公告)日：2018-10-25

申请号：US15957013

申请日：2018-04-19

申请人： Taminco BVBA

发明人： Jim Van Durme ,  Michael Schmidt ,  Karen Mollet ,  Kristof Moonen ,  Peter Roose

IPC分类号： A01N37/40 ,  A01N25/02 ,  C07C213/08 ,  C07C215/08 ,  C07C217/08 ,  C07C215/10 ,  C07C65/21 ,  C07C51/41 ,  C07F9/38 ,  A01N57/20 ,  C07C59/70 ,  A01N39/04 ,  C07C209/68 ,  C07C211/11 ,  C07C255/30 ,  C07C253/30

CPC分类号： A01N37/40 ,  A01N25/02 ,  A01N39/04 ,  A01N57/20 ,  C07C51/412 ,  C07C59/70 ,  C07C65/21 ,  C07C209/68 ,  C07C211/11 ,  C07C213/08 ,  C07C215/08 ,  C07C215/10 ,  C07C217/08 ,  C07C253/30 ,  C07C255/30 ,  C07F9/3808 ,  C07F9/3813

摘要： The invention is a herbicidal composition containing an alkanolamine salt of an dicamba capable of remaining as a single phase liquid over a period of at least 1 week and containing low amounts of water and high loadings of the salt. Such herbicidal compositions are capable of remaining liquid in the absence of high amounts of water, thereby enhancing their capacity to remain liquid over an extended period of time when exposed to environmental conditions to improve their effectiveness to transport the active salt through a leafy substrate and can reduce transportation costs by increasing the salt loading without compromising the stability of the composition.

公开(公告)号：US09624156B2

公开(公告)日：2017-04-18

申请号：US14925084

申请日：2015-10-28

申请人： United Therapeutics Corporation

发明人： Ken Phares ,  David Mottola ,  Roger Jeffs

IPC分类号： C07C59/13 ,  A61K9/00 ,  A61K31/192 ,  A61K38/00 ,  C07C69/712 ,  C07C59/70 ,  C07C229/08 ,  C07C235/06 ,  C07C235/08 ,  C07C259/06 ,  C07F9/09 ,  C07F9/117 ,  C07C51/41 ,  A61K31/235 ,  A61K31/216 ,  A61K31/223

CPC分类号： C07C59/13 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/192 ,  A61K31/216 ,  A61K31/223 ,  A61K31/235 ,  C07C51/412 ,  C07C59/70 ,  C07C69/712 ,  C07C229/08 ,  C07C235/06 ,  C07C235/08 ,  C07C259/06 ,  C07C2103/10 ,  C07C2603/10 ,  C07F9/091 ,  C07F9/117

摘要： This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.

公开(公告)号：US20160348213A1

公开(公告)日：2016-12-01

申请号：US15081344

申请日：2016-03-25

申请人： XIAMEN INSTITUTE OF RARE EARTH MATERIALS

发明人： Xiaoqi SUN ,  Yanliang WANG ,  Yamin DONG

IPC分类号： C22B59/00 ,  C07F9/54 ,  C07C211/63 ,  C22B3/44 ,  C07C59/70

CPC分类号： C22B59/00 ,  C07C59/70 ,  C07F9/5407 ,  C22B3/0005 ,  Y02P10/234

摘要： An extractant and a method for the extraction and separation of yttrium are disclosed in the invention. Cations of said extractant are selected from the group of quaternary phosphonium or quaternary ammonium, and the anion is sec-octylphenoxy acetate. The extractant has a simple composition, the formulated organic phase has stable properties and can be recycling used without significantly decreased concentration. The present invention used a mixed organic phase consisting of an extractant and a diluent to extract a rare earth feed liquid containing yttrium, and then washed and back extracted it with deionized water so that the consumption of acid and alkali in all the processes of extraction, washing and back extraction was avoided. Therefore, the extraction is carried out under a low acidity and a high extraction efficiency was ensured. The organic phase can be recycling used without saponification, so that no ammonia wastewater was produced in the processes.

摘要翻译： 在本发明中公开了萃取剂和萃取和分离钇的方法。 所述萃取剂的阳离子选自季鏻或季铵，阴离子为仲辛基苯氧基乙酸酯。 萃取剂组成简单，配制的有机相具有稳定的性能，可循环使用而不会显着降低浓度。 本发明使用由萃取剂和稀释剂组成的混合有机相萃取含有钇的稀土进料液，然后用去离子水洗涤并反萃取，使所有萃取过程中的酸和碱的消耗量， 避免了洗涤和反萃取。 因此，在低酸度下进行提取，确保提取效率高。 有机相可以在不皂化的情况下循环利用，从而在工艺中不产生氨废水。

公开(公告)号：US09309376B2

公开(公告)日：2016-04-12

申请号：US13792175

申请日：2013-03-10

申请人： Charles Francis Palmer, Jr. ,  Lester Arnold Haney, II ,  Calvin M. Wicker, Jr.

发明人： Charles Francis Palmer, Jr. ,  Lester Arnold Haney, II ,  Calvin M. Wicker, Jr.

IPC分类号： C08K5/06 ,  C08K5/51 ,  C08K5/09 ,  C08K5/098 ,  C08K5/41 ,  C08K5/52

CPC分类号： C08K5/06 ,  C07C43/164 ,  C07C59/70 ,  C07C305/10 ,  C07F9/11 ,  C08G65/02 ,  C08G65/14 ,  C08G65/22 ,  C08G65/2612 ,  C08G65/326 ,  C08G65/331 ,  C08K5/09 ,  C08K5/098 ,  C08K5/41 ,  C08K5/52 ,  C08L71/02 ,  C09D171/02

摘要： Waterborne coatings are described having an acceptable balance of properties both during the storage of coating, application and drying. The period in which irregularities in a freshly applied coating can be repaired without resulting in brush marks is referred to as the open time. Aqueous coatings generally employ dispersed high molecular weight polymers as binders. These binders often provide short open times when the coating is dried since the dispersed polymer particles tend to be immobilized quickly in the edge region of an applied coating. As a result, the viscosity of the coating increases rapidly, which leads to a limited window of workability. The instant invention provides additives that are not volatile but that will extend the time that the film is malleable after after it is applied without interfering with other attributes, such as the resistance of the coating to freezing while in the can prior to application.

摘要翻译： 描述了水性涂料在包衣，施用和干燥的储存期间具有可接受的性能平衡。 将新涂涂层的不规则性修复而不会产生刷痕的时间称为开放时间。 水性涂​​料通常使用分散的高分子量聚合物作为粘合剂。 当涂层干燥时，这些粘合剂通常提供短的开放时间，因为分散的聚合物颗粒易于快速固定在涂覆的涂层的边缘区域中。 结果，涂层的粘度迅速增加，这导致有限的可加工性窗口。 本发明提供了不挥发性的添加剂，但是延长了膜施用后的延展时间，而不干扰其它特性，例如涂布前在罐中的涂层的冷冻性。

公开(公告)号：US20160016884A1

公开(公告)日：2016-01-21

申请号：US14868233

申请日：2015-09-28

申请人： HONSHU CHEMICAL INDUSTRY CO., LTD.

发明人： Akira YOSHITOMO ,  Tatsuya IWAI

IPC分类号： C07C69/738

CPC分类号： C07C69/738 ,  C07C39/17 ,  C07C47/57 ,  C07C59/70 ,  C07C69/712 ,  C07C2601/14 ,  C07C2603/74

摘要： A tetrakis(ether-substituted formylphenyl) expressed by General Formula (1): wherein R1 represents an alkyl group with 1 to 8 carbon atoms or alkoxyl group with 1 to 8 carbon atoms, or aromatic hydrocarbon group or saturated hydrocarbon group with 1 to 8 carbon atoms having an aromatic hydrocarbon group, n represents 0 or an integer of 1 to 3, R2 represents a divalent monocyclic or fused-ring aromatic hydrocarbon group with 6 to 15 carbon atoms or divalent aliphatic hydrocarbon group with 1 to 8 carbon atoms that may have a monocyclic or fused-ring aromatic hydrocarbon group with 6 to 15 carbon atoms, R3 represents a hydrogen atom or alkyl group with 1 to 6 carbon atoms, A represents a tetravalent carbon atom group or tetravalent saturated hydrocarbon group with 2 or more carbon atoms, where, if A is a tetravalent saturated hydrocarbon group with 2 or more carbon atoms, the two carbon atoms in the A group are bonded with two phenyl groups, respectively.

摘要翻译： 由通式（1）表示的四（醚取代的甲酰基苯基）：其中R1表示碳原子数为1〜8的烷基或碳原子数1〜8的烷氧基，或芳香族烃基或碳原子数1〜8的饱和烃基 具有芳香族烃基的碳原子，n表示0或1〜3的整数，R 2表示碳原子数6〜15的二价单环或稠环芳香族烃基或碳原子数1〜8的2价脂肪族烃基， 具有6至15个碳原子的单环或稠环芳族烃基，R 3表示氢原子或具有1至6个碳原子的烷基，A表示具有2个或更多个碳原子的四价碳原子基团或四价饱和烃基 其中，如果A是具有2个或更多个碳原子的四价饱和烃基，则A基团中的两个碳原子分别与两个苯基键合。

公开(公告)号：US08846292B2

公开(公告)日：2014-09-30

申请号：US13339662

申请日：2011-12-29

申请人： Masatoshi Echigo ,  Dai Oguro

发明人： Masatoshi Echigo ,  Dai Oguro

IPC分类号： G03F7/004 ,  G03F7/09 ,  G03F7/20 ,  G03F7/30 ,  G03F7/36

CPC分类号： G03F7/0045 ,  C07C37/20 ,  C07C39/12 ,  C07C39/17 ,  C07C39/42 ,  C07C45/49 ,  C07C59/70 ,  C07C65/105 ,  C07C69/736 ,  C07C2601/14 ,  C07C2603/74 ,  C07C2603/92 ,  C07D307/33 ,  C08G8/04 ,  C08G8/08 ,  C08G8/20 ,  G03F7/022 ,  G03F7/038 ,  G03F7/0382 ,  G03F7/0392 ,  G03F7/0397 ,  Y10S430/106 ,  Y10S430/108 ,  Y10S430/109 ,  C07C47/546

摘要： A radiation-sensitive composition containing a resist compound having a high sensitivity, a high resolution, a high etching resistance, and a low outgas which forms a resist pattern with good shape and a method of forming a resist pattern and novel compositions for forming a photoresist under coat film which is excellent in optical properties and etching resistance and contains substantially no sublimable substance and an under coat film formed by the composition. Radiation-sensitive composition containing a solvent and a cyclic compound having, e.g., a cyclic compound (A) having a molecular weight of 700 to 5000 which is synthesized by the condensation reaction of a compound having 2 to 59 carbon atoms and 1 to 4 formyl groups with a compound having 6 to 15 carbon atoms and 1 to 3 phenolic hydroxyl groups, and a cyclic compound for use in the radiation-sensitive composition.

摘要翻译： 含有具有高灵敏度，高分辨率，高耐蚀刻性和形成具有良好形状的抗蚀剂图案的低气体的抗蚀剂化合物的辐射敏感性组合物和形成抗蚀剂图案的方法和用于形成光致抗蚀剂的新型组合物 底涂层，其光学性能和耐蚀刻性优异，并且基本上不含升华物质和通过该组合物形成的底涂膜。 含有溶剂和环状化合物的辐射敏感性组合物，其具有例如分子量为700〜5000的环状化合物（A），其通过具有2〜59个碳原子的化合物和1〜4个甲酰基 具有6至15个碳原子和1至3个酚羟基的化合物的基团，以及用于辐射敏感组合物的环状化合物。

公开(公告)号：US20140099370A1

公开(公告)日：2014-04-10

申请号：US14034867

申请日：2013-09-24

申请人： Bezwada Biomedical, LLC

发明人： Rao S Bezwada

IPC分类号： A61K47/48 ,  A61K45/06 ,  C07C69/63 ,  A61K8/88 ,  C07C59/70 ,  C07D311/36 ,  A61L31/16 ,  A61K31/785 ,  C07C69/736

CPC分类号： A61K47/481 ,  A61K8/85 ,  A61K8/88 ,  A61K31/785 ,  A61K45/06 ,  A61K47/32 ,  A61K47/34 ,  A61K2800/10 ,  A61L17/105 ,  A61L17/12 ,  A61L17/145 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61Q19/00 ,  C07C59/70 ,  C07C69/63 ,  C07C69/736 ,  C07D311/36 ,  C08G63/16 ,  C08G63/672 ,  C08G69/40 ,  C08G69/44 ,  C08L77/12 ,  C08L67/04

摘要： The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.

摘要翻译： 本发明涉及衍生自官能化的生物活性化合物的可生物降解聚合物（例如聚酯和聚酯酰胺），其可以以受控方式在生物降解中提供生物活性化合物的位点特异性递送。