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公开(公告)号：US10770170B2
公开(公告)日：2020-09-08
申请号：US15914356
申请日：2018-03-07
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N33/48 , G01N33/50 , G16B25/00 , G16B5/00 , C12Q1/6851 , G16B25/20 , G16B40/10 , C12Q1/68 , G01N21/64 , C12Q1/6825 , G06F17/10 , G06F17/11 , G16B40/00
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号：US10751025B2
公开(公告)日：2020-08-25
申请号：US16689427
申请日：2019-11-20
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Alaina Ann Brinley Rajagopal
IPC: A61B7/04 , A61B5/0205 , A61B8/00 , A61B5/00 , G01S15/89 , A61B5/145 , A61B5/08 , A61B5/021 , A61B8/06 , A61B8/08 , A61B8/02
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号：US20200138400A1
公开(公告)日：2020-05-07
申请号：US16689427
申请日：2019-11-20
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Alaina Ann Brinley Rajagopal
IPC: A61B7/04 , A61B5/0205 , A61B8/00 , A61B5/00 , G01S15/89
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
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公开(公告)号：US10077475B2
公开(公告)日：2018-09-18
申请号：US14633094
申请日：2015-02-26
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer , Mark D. Goldberg
IPC: C12Q1/68 , C12Q1/6883 , C12Q1/6851 , C12Q1/70
CPC classification number: C12Q1/6883 , C12Q1/68 , C12Q1/6851 , C12Q1/701 , C12Q1/703 , C12Q2600/156 , Y10T436/143333 , C12Q2561/113 , C12Q2565/101 , C12Q2527/101 , C12Q2565/1015 , C12Q2565/133
Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
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公开(公告)号：US10066263B2
公开(公告)日：2018-09-04
申请号：US15623974
申请日：2017-06-15
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Emil P. Kartalov
CPC classification number: C12Q1/686 , B01J2219/00659 , C07H21/04 , G01N2021/6417
Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.
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Patent Agency Ranking
公开(公告)号：US09243277B2
公开(公告)日：2016-01-26
申请号：US14753741
申请日：2015-06-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Axel Scherer , Michael D. Henry , Sameer Walavalkar , Thomas A. Tombrello , Andrew P. Homyk
IPC: G01R1/067 , G01R31/00 , C12Q1/02 , H01L29/78 , H01L29/66 , G01N27/327 , G01N27/414 , A61B5/04 , H01L29/41 , H01L29/423 , H01L29/49 , G01R1/073
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.
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57.发明授权公开(公告)号：US09238833B2
公开(公告)日：2016-01-19
申请号：US14028431
申请日：2013-09-16
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Samson Chen , Aditya Rajagopal , Axel Scherer
CPC classification number: C12Q1/686 , B01L7/52 , B01L2200/12 , B01L2300/0877 , B01L2300/1827 , H05K1/0212 , H05K1/0272 , H05K1/16 , H05K3/4644 , H05K3/4697 , Y10T29/49155
Abstract: Novel methods and systems for polymerase chain reaction (PCR) are disclosed. A PCR device has a bottom heater layer, a central reacting layer, and a top heater layer. The central reacting layer has a PCR reacting chamber connected with fluidics channels. Photoluminescence of a DNA solution in the PCR reactive chamber is carried out through the transparent top layers.
Abstract translation: 公开了用于聚合酶链反应（PCR）的新方法和系统。 PCR装置具有底部加热器层，中央反应层和顶部加热器层。 中央反应层具有与流体通道连接的PCR反应室。 PCR反应室中DNA溶液的光致发光通过透明顶层进行。
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公开(公告)号：US09099436B2
公开(公告)日：2015-08-04
申请号：US13852476
申请日：2013-03-28
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Aditya Rajagopal , Axel Scherer , Michael D. Henry , Sameer Walavalkar , Thomas A. Tombrello , Andrew P. Homyk
IPC: G01R1/067 , H01L29/423 , H01L29/78 , H01L29/66 , G01N27/327 , G01N27/414 , A61B5/04 , H01L29/41 , H01L29/49 , G01R1/073
CPC classification number: C12Q1/02 , A61B5/04001 , G01N27/3275 , G01N27/4146 , G01R1/06711 , G01R1/07342 , H01L29/413 , H01L29/42376 , H01L29/4966 , H01L29/66477 , H01L29/78 , H01L29/7831
Abstract: The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example applications among these various sensing applications include bio-sensing and chemical-sensing applications. For bio-sensing applications the probe, which is fabricated upon a silicon substrate, includes a bio-sensing element such as a nano-pillar transistor, and for chemical-sensing applications the probe includes a sensing element that has a functionalized contact area whereby the sensing element generates a voltage when exposed to one or more chemicals of interest.
Abstract translation: 本文公开的探针的基本结构和功能允许灵活地并入到探针中，用于各种感测应用的各种感测元件。 这些各种感测应用中的两个示例应用包括生物感测和化学感测应用。 对于生物感测应用，制造在硅衬底上的探针包括诸如纳米柱晶体管的生物感测元件，并且对于化学感测应用，探针包括具有功能化接触区域的感测元件， 当暴露于感兴趣的一种或多种化学品时，感测元件产生电压。
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59.发明授权Nanopillar field-effect and junction transistors with functionalized gate and base electrodes 有权具有功能化栅极和基极的纳米柱场效应和结型晶体管公开(公告)号：US09070733B2
公开(公告)日：2015-06-30
申请号：US13941295
申请日：2013-07-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SANOFI
Inventor： Aditya Rajagopal , Chieh-feng Chang , Oliver Plettenburg , Stefan Petry , Axel Scherer , Charles L. Tschirhart
IPC: H01L29/73 , H01L29/78 , B82Y15/00 , H01L29/732 , H01L29/06 , H01L29/41 , G01N27/414
CPC classification number: H01L29/413 , B82Y15/00 , G01N27/4145 , G01N27/4146 , H01L29/0676 , H01L29/45 , H01L29/49 , H01L29/73 , H01L29/732 , H01L29/735 , H01L29/78
Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.
Abstract translation: 描述了用于分子感测的系统和方法。 描述了基于场效应或双极结型晶体管的分子传感器。 这些晶体管具有纳米柱，其具有与基极或栅电极接触的官能化层。 功能层可以结合分子，导致传感器中的电信号。
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60.发明授权Methods of modulating microlasers at ultralow power levels, and systems thereof 有权在超低功率水平下调节微量激光器的方法及其系统公开(公告)号：US09031102B2
公开(公告)日：2015-05-12
申请号：US13764620
申请日：2013-02-11
Applicant: California Institute of Technology
Inventor： Seheon Kim , Axel Scherer , Aditya Rajagopal , Chieh-Feng Chang
CPC classification number: H01S3/0627 , A61B5/1459 , H01S3/025 , H01S3/091 , H01S3/102 , H01S3/1028 , H01S3/105 , H01S3/115 , H01S5/0607 , H01S5/0612 , H01S5/1042 , H01S5/3013
Abstract: A microlaser system includes an optical source, a microlaser, an actuator switch, and a photovoltaic power source. The microlaser, which includes a control element, is optically pumped by at least a portion of light emitted by the optical source. The actuator switch is configured to be activated by a triggering event. Furthermore, the photovoltaic power source is coupled in a series connection with the actuator switch and the control element, the series connection configured to connect the photovoltaic power source to the control element of the microlaser when the actuator switch is activated by the triggering event.
Abstract translation: 微型激光系统包括光源，微激光器，致动器开关和光伏电源。 包括控制元件的微激光器被由光源发射的光的至少一部分光泵浦。 执行器开关被配置为由触发事件激活。 此外，光伏电源与致动器开关和控制元件串联连接，串联连接被配置为当致动器开关被触发事件激活时将光伏电源连接到微型激光器的控制元件。
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