公开(公告)号：US20240092874A1

公开(公告)日：2024-03-21

申请号：US18069456

申请日：2022-12-21

申请人： Longhu Laboratory ,  Zhengzhou University

发明人： Gaiping Zhang ,  Aiping Wang ,  Peiyang Ding ,  Yaning Sun ,  Yumei Chen ,  Jianguo Zhao ,  Hongliang Liu ,  Haili Wang

IPC分类号： C07K16/10 ,  G01N33/543 ,  G01N33/569

CPC分类号： C07K16/10 ,  G01N33/54388 ,  G01N33/56983 ,  G01N2469/20

摘要： The present invention provides a rabies virus monoclonal antibody 2F2 and universal rabies virus antibody rapid detection test paper and belongs to the technical field of biological detection. An amino acid sequence of the monoclonal antibody 2F2 is shown as SEQ ID No. 1. The monoclonal antibody 2F2 provided by the present invention specifically binds to rabies virus G proteins, and preparation of the monoclonal antibody 2F2 into test paper has the advantages of rapidity, accuracy, sensitivity, specificity and low cost.

公开(公告)号：US11926648B2

公开(公告)日：2024-03-12

申请号：US17241884

申请日：2021-04-27

申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED ,  INSTITUT PASTEUR

发明人： Felix Rey ,  Giovanna Barba Spaeth ,  Marie-Christine Vaney ,  Alexander Rouvinski ,  Gavin Screaton ,  Juthathip Mongkolsapaya

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61K39/12 ,  A61P31/14 ,  C07K14/005 ,  C07K14/18 ,  C07K14/705 ,  G01N33/569

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61P31/14 ,  C07K14/1825 ,  C07K16/1081 ,  G01N33/56983 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24171 ,  Y02A50/30

摘要： A flavivirus Envelope Dimer Epitope (EDE) and isolated neutralizing antibody or antigen binding fragment thereof directed against the EDE for use in vaccinating an individual against one or more flaviviruses wherein the EDE is a stabilized recombinant flavivirus are provided. The dimer is: covalently stabilized with at least one disulphide inter-chain bond or one sulfhydryl-reactive crosslinker between the two sE monomers, and/or by being formed as a single polypeptide chain, and/or by linking the two sE monomers through modified sugar, and/or non-covalently stabilized by substituting at least one amino acid residue in the amino acid sequence of at least one sE monomer with at least one bulky side chain amino acid, at the dimer interface or in domain 1 (D1)/domain 3 (D3) linker of each monomer. The dimer is a homodimer or heterodimer of native and/or mutant envelope polypeptides, from DENV-1, DENV-2, DENV-3, DENV-4, Zika and/or other flavivirus.

公开(公告)号：US20240069023A1

公开(公告)日：2024-02-29

申请号：US18030465

申请日：2021-10-12

申请人： The Johns Hopkins University

发明人： Antony Rosen ,  Livia A. Casciola-Rosen

IPC分类号： G01N33/569 ,  G01N33/564 ,  G01N33/543

CPC分类号： G01N33/56983 ,  G01N33/564 ,  G01N33/54388 ,  G01N2333/165 ,  G01N2333/948 ,  G01N2469/10

摘要： Provided herein are methods for diagnosing the probability of extended duration of severe COVID19 symptoms in a subject infected with a SARS-CoV2 virus or suspected of being infected with the SARS-CoV2 virus, the method including (a) providing a biological sample from the subject; and (b) detecting the presence of an anti-ACE2 IgM antibody in the biological sample, thereby diagnosing the probability of extended duration of severe COVID19 symptoms in the subject.

公开(公告)号：US20240069015A1

公开(公告)日：2024-02-29

申请号：US18259841

申请日：2022-01-04

申请人： UNIVERSITA' DEGLI STUDI DI BARI ALDO MORO (60%) ,  ITEL TELECOMUNICAZIONI S.R.L. (40%)

发明人： Antonio SCILIMATI ,  Maria Grazia PERRONE ,  Antonio GNONI ,  Salvatore Maria SCACCO ,  Michele DIAFERIA ,  Vincenzo DIMICCOLI ,  Anna TOLOMEO ,  Antonio RIGLIETTI ,  Davide SCILIMATI

IPC分类号： G01N33/543 ,  G01N33/569

CPC分类号： G01N33/54387 ,  G01N33/56983 ,  G01N2333/165

摘要： The present invention relates to a device for identifying and monitoring possible environmental contamination by pathogenic and non-pathogenic microorganisms, e.g., viruses. The present invention further relates to a system comprising said device.

公开(公告)号：US20240067706A1

公开(公告)日：2024-02-29

申请号：US18270917

申请日：2022-01-05

申请人： CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES

发明人： Bing Sun ,  Xiaoyu Sun ,  Chunyan Yi ,  Zhiyang Ling ,  Yaguang Zhang

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61P31/14 ,  C12N5/0783 ,  G01N33/569

CPC分类号： C07K16/1003 ,  A61K39/4611 ,  A61K39/4631 ,  A61P31/14 ,  C12N5/0636 ,  G01N33/56983 ,  A61K2239/13 ,  A61K2239/38 ,  C07K2317/565 ,  C07K2317/622 ,  C12N2510/00

摘要： Disclosed are a fully human broad-spectrum neutralizing antibody against coronavirus, and the use thereof. Specifically disclosed are a fully human monoclonal antibody against an S2 region of coronavirus S protein, a nucleic acid sequence encoding the antibody, and a preparation method therefor. The antibody can effectively bind to and neutralize a variety of coronaviruses in a broad spectrum manner, and can be used for preventing and treating diseases related to coronavirus infection, such as SARS-CoV-2. Further disclosed is the potential use thereof in vaccine design.

公开(公告)号：US20240060131A1

公开(公告)日：2024-02-22

申请号：US18150917

申请日：2023-08-03

申请人： INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES

发明人： Guanghui LIU ,  Jing Qu ,  Weiqi Zhang ,  Xiaoqian Liu ,  Zunpeng Liu ,  Zeming Wu ,  Si Wang

IPC分类号： C12Q1/6883 ,  A61K31/513 ,  A61K31/52 ,  A61P43/00 ,  C07K16/08 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/68

CPC分类号： C12Q1/6883 ,  A61K31/513 ,  A61K31/52 ,  A61P43/00 ,  C07K16/081 ,  C12Q1/70 ,  G01N33/56983 ,  G01N33/6893 ,  C12Q2600/154 ,  G01N2333/15 ,  G01N2800/7042

摘要： A method using an endogenous retrovirus (ERV) as a biomarker for detecting a degree of aging of an object or a cell, tissue or organ or isolated cell thereof. A method using an ERV as a target for treating, preventing or delaying aging of the subject or a cell, tissue or organ or isolated cell thereof.

公开(公告)号：US11906507B2

公开(公告)日：2024-02-20

申请号：US17210957

申请日：2021-03-24

申请人： The Procter & Gamble Company

发明人： Karl Shiqing Wei ,  Feng Yue ,  Hechuan Yu

IPC分类号： G01N33/483 ,  G01N33/569

CPC分类号： G01N33/4833 ,  G01N33/56916 ,  G01N33/56938 ,  G01N33/56961 ,  G01N33/56983

摘要： A method of taking a skin sample can include placing an adhesive onto a portion of skin and lifting the adhesive from the skin. A skin sample may then be tested while still on the adhesive, for example, by inoculating the sample with a bacterium, fungus, virus, or a combination.

公开(公告)号：US20240050366A1

公开(公告)日：2024-02-15

申请号：US18258861

申请日：2021-10-21

申请人： SOLYPLUS GMBH ,  LEOPOLD GMBH

发明人： Andreas VOIGT ,  Richard Dolph ANDERSEN ,  Karl SKRINER ,  Joachim BENDER

IPC分类号： A61K9/68 ,  A61K31/722 ,  C07K16/10 ,  A61K9/00 ,  A61K47/36 ,  G01N33/569

CPC分类号： A61K9/0058 ,  A61K31/722 ,  C07K16/1003 ,  A61K9/006 ,  A61K47/36 ,  G01N33/56983 ,  G01N2333/165

摘要： Compounds and compositions, their use and methods using the compounds and compositions for preventing an infection, e.g. an infection by a virus or bacterium, or treating an infection, e.g. a virus or bacterial infection, or treating a disease caused by an infection, e.g. a virus or bacterial infection, and a method of increasing the binding of virus neutralizing antibodies, an in vitro method of detecting virus-specific antibodies in a sample obtained from a subject, a compound for use in a method of detecting of virus-specific antibodies in a subject, and a kit for the detection of virus-specific antibodies.

公开(公告)号：US20240044911A1

公开(公告)日：2024-02-08

申请号：US18243566

申请日：2023-09-07

申请人： Serimmune Inc.

发明人： Patrick Sean Daugherty ,  Kathryn Vinaya Louise Kamath ,  Jack Ryan Reifert

IPC分类号： G01N33/68 ,  C07K14/285 ,  G01N33/53 ,  C07K14/44 ,  G01N33/569 ,  G01N33/564 ,  C07K14/315 ,  C07K14/195 ,  C07K14/45 ,  C07K14/435

CPC分类号： G01N33/6854 ,  G01N33/6845 ,  C07K14/285 ,  G01N33/53 ,  C07K14/44 ,  G01N33/56988 ,  G01N33/564 ,  G01N33/56944 ,  C07K14/315 ,  C07K14/195 ,  G01N33/56994 ,  G01N33/6842 ,  C07K14/45 ,  G01N33/56905 ,  G01N33/6878 ,  G01N33/56966 ,  C07K14/43554 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/569 ,  G01N2333/18 ,  G01N2333/095 ,  C12Q1/689

摘要： The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

公开(公告)号：US20240036044A1

公开(公告)日：2024-02-01

申请号：US18181325

申请日：2023-03-09

申请人： Gemina Laboratories Ltd.

发明人： Robert Crandall Greene ,  Christine BUERKI

IPC分类号： G01N33/569

CPC分类号： G01N33/56983

摘要： The present document describes a dual-affinity probe comprising an organic or inorganic surface binding peptide and a target-specific capture element, which may bind to various targets, such as pathogens. This document further describes uses of the dual-affinity probe, and kits to determine the presence of and/or quantity of a target in a sample. In particular embodiments, the dual-affinity probe is specific for SARS-CoV-2 (Spike or Nucleocapsid) protein and may be used to determine whether a subject is infected with SARS-CoV-2.