公开(公告)号：US20240325518A1

公开(公告)日：2024-10-03

申请号：US18639558

申请日：2024-04-18

申请人： Takeda Vaccines, Inc.

发明人： Jill A. LIVENGOOD ,  Holli GIEBLER ,  Hansi DEAN ,  Tatsuki SATOU ,  Raman RAO ,  Jackie MARKS ,  Mark LYONS ,  Asae SHINTANI ,  James GIFFORD ,  Sushma Kommareddy

IPC分类号： A61K39/12 ,  A61K9/00 ,  A61K39/00 ,  A61K39/39 ,  A61P31/14 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K39/39 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  C12N2770/24034 ,  C12N2770/24071 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24163 ,  C12N2770/24164

摘要： The present disclosure relates to methods for inactivating a Zika virus which can be used in vaccines and immunogenic compositions. The present disclosure also relates to a method for determining the completeness of inactivation of an arbovirus preparation.

公开(公告)号：US12098165B2

公开(公告)日：2024-09-24

申请号：US17262327

申请日：2019-05-28

申请人： Chiang Mai University ,  National Science and Technology Development Agency (NSTDA)

发明人： Nopporn Sittisombut ,  Malinee Sae-Lim ,  Nicha Charoensri ,  Poonsook Keelapang

IPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61P31/14 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5258 ,  C12N2770/24122 ,  C12N2770/24123 ,  C12N2770/24134 ,  C12N2770/24171

摘要： Modified and expressed virus-like particles are described that are capable of eliciting immune response in a mammal upon administrating a pharmaceutically efficient dosage to the mammal. The virus-like particle comprises a modified form of M and E structural proteins of flavivirus. Further, the virus-like particle comprises an amino acids sequence substantially corresponding to a sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4, wherein conserved and internally located His at multiple positions of the M and E proteins are substituted with uncharged residues, and other secretion-enhancing substitutions are introduced.

公开(公告)号：US20240216498A1

公开(公告)日：2024-07-04

申请号：US18523331

申请日：2023-11-29

申请人： Takeda Vaccines, Inc.

发明人： Joseph David Santangelo ,  Jill A. Livengood ,  Yock Ann Lee ,  Weiwen Luo

IPC分类号： A61K39/12 ,  A61K9/19 ,  A61K39/00 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K9/19 ,  C12N7/00 ,  A61K2039/5254 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24152 ,  C12N2770/24162

摘要： The present invention provides methods for large-scale flaviviral vaccine production and manufacture. The methods provided herein are specifically contemplated for large-scale production and manufacture of live, attenuated flaviviral vaccines such as live, attenuated, dengue virus vaccines. Further, the methods provided herein pertain to formulation of live, attenuated, monovalent, divalent, trivalent, or tetravalent viral vaccine products.

公开(公告)号：US12018291B2

公开(公告)日：2024-06-25

申请号：US18063823

申请日：2022-12-09

申请人： UNIVERSITY OF WASHINGTON

发明人： Edward Clark ,  Jay Wesley Chaplin

IPC分类号： A61K47/40 ,  A61K39/12 ,  A61K39/29 ,  A61K39/385 ,  A61K47/68 ,  C07K16/28 ,  C12N7/00 ,  A61K39/00

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/29 ,  A61K39/385 ,  A61K47/6811 ,  A61K47/6849 ,  C07K16/2896 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/6056 ,  C07K2319/40 ,  C07K2319/74 ,  C12N2770/24132 ,  C12N2770/24134 ,  C12N2770/28033 ,  Y02A50/30

摘要： The present invention provides compositions of CD 180 targeting molecules coupled to heterologous antigens, and their use in treating and/or limiting disease.

公开(公告)号：US20240189407A1

公开(公告)日：2024-06-13

申请号：US18554935

申请日：2022-04-11

申请人： SAIBA AG

发明人： Kaspars TARS ,  Ilva LIEKNINA ,  Darja CERNOVA

IPC分类号： A61K39/00 ,  A61K39/015 ,  A61K39/02 ,  A61K39/12 ,  A61K39/35 ,  A61P31/14 ,  A61P37/08 ,  C12N7/00

CPC分类号： A61K39/00114 ,  A61K39/001134 ,  A61K39/001138 ,  A61K39/015 ,  A61K39/0225 ,  A61K39/12 ,  A61K39/35 ,  A61P31/14 ,  A61P37/08 ,  C12N7/00 ,  C12N2710/12034 ,  C12N2760/18534 ,  C12N2760/18571 ,  C12N2770/20034 ,  C12N2770/20071 ,  C12N2770/24134 ,  C12N2795/18022 ,  C12N2795/18023

摘要： The present invention relates to a modified virus-like particle of RNA bacteriophage AP205 (AP205 VLP) comprising AP205 coat protein dimers to which antigenic polypeptides are fused at the N-terminus and/or at the C-terminus. The modified AP205 VLPs can be used as a platform, in particular for vaccine development, in generating immune responses against a variety of antigens.

公开(公告)号：US20240156941A1

公开(公告)日：2024-05-16

申请号：US18550730

申请日：2022-03-17

申请人： The University of North Carolina at Chapel Hill

发明人： Ralph Baric ,  Long Ping Victor Tse ,  Rita Meganck

IPC分类号： A61K39/12 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  G01N33/569

CPC分类号： A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  G01N33/56983 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  C12N2770/24122 ,  C12N2770/24123 ,  C12N2770/24134 ,  C12N2770/24151 ,  G01N2333/185 ,  G01N2469/20

摘要： This invention relates to mature flavivirus particles and methods of making and using the same. This invention further relates to flavivirus prM glycoproteins, nucleic acids encoding the same, as well as particles, populations, and compositions comprising the same. Also disclosed are methods of making and using the prM glycoproteins of the invention.

公开(公告)号：US20240150409A1

公开(公告)日：2024-05-09

申请号：US18141055

申请日：2023-04-28

申请人： iSD Immunotech ApS

发明人： Mogens RYTTERGAARD DUCH ,  Shervin BAHRAMI

IPC分类号： C07K14/005 ,  A61K39/12 ,  C07K1/00 ,  C07K4/02 ,  C07K7/08 ,  C07K14/08 ,  C12N7/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  C07K1/00 ,  C07K4/02 ,  C07K7/08 ,  C07K14/08 ,  C12N7/00 ,  C12N2760/12121 ,  C12N2760/12122 ,  C12N2760/12221 ,  C12N2760/12222 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16221 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16321 ,  C12N2760/16322 ,  C12N2770/24121 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24221 ,  C12N2770/24222 ,  C12N2770/24234 ,  C12N2770/24321 ,  C12N2770/24322 ,  C12N2770/28021 ,  C12N2770/28034 ,  C12N2770/36121 ,  C12N2770/36122 ,  C12N2770/36221 ,  C12N2770/36222

摘要： The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune response by first identifying then mutating the immunosuppressive domains in fusion proteins of enveloped RNA viruses resulting in decreased immunosuppressive properties of viral envelope proteins from the viruses.

公开(公告)号：US11931406B2

公开(公告)日：2024-03-19

申请号：US16772131

申请日：2018-12-12

申请人： CureVac SE ,  Sanofi Pasteur

发明人： Patrick Baumhof ,  Wolfgang Grosse ,  Edith Jasny ,  Thomas Kramps ,  Daniel Voss ,  Julia Dannenmaier ,  Valérie Lecouturier ,  Yves Girerd-Chambaz

IPC分类号： A61K39/12 ,  A61P31/14 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61P31/14 ,  A61K2039/53 ,  A61K2039/575 ,  A61K2039/6031 ,  C12N2770/24134

摘要： The present invention is directed to an artificial nucleic acid and to a polypeptide suitable for use in the treatment or prophylaxis of an infection with a flavivirus, in particular an infection with yellow fever virus or with dengue virus, or of a disorder related to such an infection. The present invention is also directed to a composition, preferably an immunogenic composition, comprising the artificial nucleic acid or the inventive polypeptide. In particular, the present invention concerns an immunogenic composition against a flavivirus, such as yellow fever virus or dengue virus. Further, the invention concerns a kit, particularly a kit of parts, comprising the artificial nucleic acid, polypeptide or (immunogenic) composition. The invention is further directed to a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptide, composition, in particular the first and second medical uses of the immunogenic composition according to the invention.

公开(公告)号：US20230279429A1

公开(公告)日：2023-09-07

申请号：US18048828

申请日：2022-10-21

申请人： Vishwas Dattatraya Joshi

发明人： Vishwas Dattatraya Joshi ,  U.M. Sreenivasa Murthy ,  Shailendra Devicharan Rane ,  Manasi Sanjay Nade

IPC分类号： C12N15/86 ,  A61P37/04 ,  A61P35/00

CPC分类号： C12N15/86 ,  A61P37/04 ,  A61P35/00 ,  C12N2760/18443 ,  C12N2840/20 ,  C12N2770/24134 ,  C12N2770/24123 ,  C12N2760/18432 ,  C12N2760/18421 ,  C12N2760/18433

摘要： This invention comprises: compositions comprising a derivative, plasmids, a reagent kit and methods of making these compositions a derivative, vaccine- and non-vaccine-compositions of above for causing death of cancer cells that form part of a tumour and virus infected Dengue, Measles and other diseased cells; the derivative comprising replicating as well as non-replicating derivatives of an attenuated negative stranded RNA virus belonging to family paramyxoviridae, including Measles Virus, comprising a single additional transcriptional unit carrying either only one or two or more non-viral genes, and the non-replicating derivatives being free from contaminating replicating Measles Virus (b) a Measles Virus packaging cell line for making above compositions, expressing the M, F and H proteins of MV stably. And (c) a reagent kit for producing the Measles Virus derivatives described above.

公开(公告)号：US11730802B2

公开(公告)日：2023-08-22

申请号：US16761329

申请日：2018-11-05

申请人： TAKEDA VACCINES, INC.

发明人： Jill A Livengood ,  Hansi Dean ,  Htay Htay Han ,  Raman Rao ,  Jackie Marks ,  Gary Dubin ,  Laurence De Moerlooze ,  Hetal Patel ,  Sushma Kommareddy

IPC分类号： A61K39/12 ,  A61K39/00 ,  A61K39/39 ,  A61K9/00 ,  C12N7/00 ,  A61P31/14

CPC分类号： A61K39/12 ,  A61K9/0019 ,  A61K39/39 ,  A61P31/14 ,  C12N7/00 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  C12N2770/24034 ,  C12N2770/24071 ,  C12N2770/24134 ,  C12N2770/24151 ,  C12N2770/24163 ,  C12N2770/24164

摘要： The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.