公开(公告)号：US20240216498A1

公开(公告)日：2024-07-04

申请号：US18523331

申请日：2023-11-29

申请人： Takeda Vaccines, Inc.

发明人： Joseph David Santangelo ,  Jill A. Livengood ,  Yock Ann Lee ,  Weiwen Luo

IPC分类号： A61K39/12 ,  A61K9/19 ,  A61K39/00 ,  C12N7/00

CPC分类号： A61K39/12 ,  A61K9/19 ,  C12N7/00 ,  A61K2039/5254 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24152 ,  C12N2770/24162

摘要： The present invention provides methods for large-scale flaviviral vaccine production and manufacture. The methods provided herein are specifically contemplated for large-scale production and manufacture of live, attenuated flaviviral vaccines such as live, attenuated, dengue virus vaccines. Further, the methods provided herein pertain to formulation of live, attenuated, monovalent, divalent, trivalent, or tetravalent viral vaccine products.