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公开(公告)号：US20190218261A1
公开(公告)日：2019-07-18
申请号：US16333137
申请日：2017-09-13
CPC分类号： C07K14/4702 , C07K14/315 , C07K2319/09 , C07K2319/85 , C12N9/0032 , C12N9/0069 , C12N9/0071 , C12N9/22 , C12N9/2497 , C12N15/09 , C12N15/113 , C12N15/85 , C12N15/902 , C12Y113/1102 , C12Y114/11 , C12Y301/21001
摘要： Provided herein are, inter alia, compositions and methods for the delivery of enhanced demethylation activity to target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
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公开(公告)号：US20180071370A1
公开(公告)日：2018-03-15
申请号：US15530666
申请日：2015-06-19
CPC分类号： A61K38/465 , A61K9/0053 , A61K31/337 , A61K31/513 , A61K31/675 , A61K31/704 , A61K31/7048 , C12Y301/21 , C12Y301/21001 , A61K2300/00
摘要： The invention relates to the use of a deoxyribonuclease (DNase) enzyme for prevention or amelioration of toxicity associated with various cytostatic and/or cytotoxic chemotherapeutic compounds and radiation therapy.
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公开(公告)号：US20180028449A1
公开(公告)日：2018-02-01
申请号：US15635169
申请日：2017-06-27
发明人： Michael P. Malakhov , Fang Fang
IPC分类号： A61K9/16 , A61K9/19 , A61K9/50 , A61K31/198 , A61K31/337 , C12N15/113 , C12N9/96 , C12N7/00 , C07K14/765 , C07K9/00 , C07D305/14 , A61K38/48 , A61K38/47 , A61K38/46 , A61K38/42 , A61K38/38 , A61K38/18 , A61K38/17 , A61K38/16 , A61K38/14 , A61K38/12 , A61K38/08 , A61K35/76 , A61K31/724 , A61K31/721 , A61K31/7036 , A61K31/65 , A61K31/5575 , A61K31/557 , A61K31/555 , A61K31/43 , A61K31/405 , A61K31/343 , A61K9/00
CPC分类号： A61K9/1682 , A61K9/0048 , A61K9/0075 , A61K9/1652 , A61K9/1658 , A61K9/19 , A61K9/5089 , A61K31/198 , A61K31/337 , A61K31/343 , A61K31/405 , A61K31/43 , A61K31/555 , A61K31/557 , A61K31/5575 , A61K31/65 , A61K31/7036 , A61K31/721 , A61K31/724 , A61K35/76 , A61K38/08 , A61K38/12 , A61K38/14 , A61K38/168 , A61K38/1709 , A61K38/1808 , A61K38/38 , A61K38/385 , A61K38/42 , A61K38/465 , A61K38/47 , A61K38/4826 , C07D305/14 , C07K9/008 , C07K14/765 , C12N7/00 , C12N9/96 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/50 , C12N2330/30 , C12N2770/00021 , C12N2770/00051 , C12Y301/21001 , C12Y301/27005 , C12Y302/00 , C12Y302/01017 , C12Y302/01018 , C12Y304/21004 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/401 , Y02A50/402 , Y02A50/411 , Y02A50/469 , Y02A50/47 , Y02A50/471 , Y02A50/478 , Y02A50/481 , Y02A50/483 , Y02A50/49 , Y02A50/491
摘要： Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.
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公开(公告)号：US09770492B2
公开(公告)日：2017-09-26
申请号：US15157910
申请日：2016-05-18
CPC分类号： A61K38/465 , C12Q1/6883 , C12Q2600/156 , C12Y301/00 , C12Y301/21001
摘要： The invention is directed to treatment of systemic DNA mutation diseases accompanied with development of somatic mosaicism and elevation of blood extracellular DNA. The inventive method comprises introducing a DNASE enzyme into the systemic blood circulation of a patient in doses and regimens which are sufficient to decrease average molecular weight of circulating extracellular blood DNA in the blood of said patient.
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公开(公告)号：US20170106057A1
公开(公告)日：2017-04-20
申请号：US15397595
申请日：2017-01-03
发明人： Sandeep Jain
CPC分类号： A61K38/465 , A61K9/0048 , A61K31/465 , A61K45/05 , A61K45/06 , C12Q1/6816 , C12Y301/21001 , A61K2300/00
摘要： Provided herein is a composition and a method for treating nucleic acid-related eye disease.
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公开(公告)号：US09603906B2
公开(公告)日：2017-03-28
申请号：US14375439
申请日：2013-01-31
申请人： Protalix Ltd.
发明人： Yoseph Shaaltiel , Uri Hanania , Tali Kizhner , Yulia Matiuhin , Liat Fux , Avidor Shulman
IPC分类号： A61K38/46 , C12N9/22 , C12N15/82 , A61K9/00 , A61K38/47 , A61K33/06 , A61K45/06 , A61K9/14 , A61K33/14
CPC分类号： A61K38/465 , A61K9/007 , A61K9/0075 , A61K9/14 , A61K33/06 , A61K33/14 , A61K38/47 , A61K45/06 , C12N9/22 , C12N15/8221 , C12N15/8257 , C12Y301/21001 , C12Y302/01052
摘要： An inhalable pharmaceutical composition for pulmonary administration comprising human DNase I and a liquid carrier and, more particularly, but not exclusively, to methods, liquid pharmaceutical inhalation devices and systems for the therapeutic use thereof are provided.
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公开(公告)号：US20170056482A1
公开(公告)日：2017-03-02
申请号：US15287447
申请日：2016-10-06
IPC分类号： A61K38/46
CPC分类号： A61K38/465 , C12Q1/6883 , C12Q2600/156 , C12Y301/00 , C12Y301/21001
摘要： The invention is directed to treatment of systemic DNA mutation diseases accompanied with development of somatic mosaicism and elevation of blood extracellular DNA. The inventive method comprises introducing a DNASE enzyme into the systemic blood circulation of a patient in doses and regimens which are sufficient to decrease average molecular weight of circulating extracellular blood DNA in the blood of said patient.
摘要翻译： 本发明涉及伴随体细胞嵌合体发育和血细胞外DNA升高的全身性DNA突变疾病的治疗。 本发明的方法包括将DNASE酶引入患者的全身血液循环中，剂量和方案足以降低患者血液中的循环细胞外血液DNA的平均分子量。
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48.发明申请METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VASO-OCCLUSIVE CRISIS 审中-公开治疗VASO-OCCLUSIVE CRISIS的方法和药物组合物公开(公告)号：US20170049862A1
公开(公告)日：2017-02-23
申请号：US15307603
申请日：2015-04-29
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ PARIS DESCARTES , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
IPC分类号： A61K38/46
CPC分类号： A61K38/465 , C12Y301/21001 , C12Y301/21003 , C12Y301/21004
摘要： The present invention relates to methods and pharmaceutical compositions for treating vaso-occlusive crises. In particular, the present invention relates to a method of treating a vaso-occlusive crisis in a subject in need thereof comprising administering to the subject a therapeutically effective amount of agent capable of degrading, destabilizing or depleting the blood-borne extracellular DNA from the blood of the subject.
摘要翻译： 本发明涉及用于治疗血管闭塞性危机的方法和药物组合物。 特别地，本发明涉及一种治疗有此需要的受试者的血管闭塞性危象的方法，包括向受试者施用治疗有效量的能够从血液中降解，不稳定或消耗血液中的细胞外DNA的试剂 的主题。
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公开(公告)号：US20160331839A1
公开(公告)日：2016-11-17
申请号：US15111564
申请日：2015-01-16
CPC分类号： A61K47/48215 , A61K9/0073 , A61K9/08 , A61K38/1709 , A61K38/465 , A61K38/55 , A61K38/57 , A61K47/60 , A61K2039/505 , A61K2039/543 , C07K16/244 , C07K2317/54 , C07K2317/55 , C07K2317/94 , C12Y301/21001
摘要： The present invention relates to a compound comprising one or more PEG moieties, wherein said compound is a therapeutic agent active for treating a respiratory disease. The present invention also relates to the use of a PEGylated therapeutic agent for treating a respiratory disease. Another object of the invention is a method for enhancing the bioavailability of a therapeutic agent, for enhancing the pulmonary residency of a therapeutic agent and/or for reducing the pulmonary clearance of a therapeutic agent, wherein said methods comprise the PEGylation of the therapeutic agent.
摘要翻译： 本发明涉及包含一个或多个PEG部分的化合物，其中所述化合物是用于治疗呼吸系统疾病的治疗剂。 本发明还涉及聚乙二醇化治疗剂用于治疗呼吸系统疾病的用途。 本发明的另一个目的是提高治疗剂的生物利用度的方法，用于增强治疗剂的肺驻留和/或降低治疗剂的肺清除率，其中所述方法包括治疗剂的聚乙二醇化。
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公开(公告)号：US20160319225A1
公开(公告)日：2016-11-03
申请号：US15139368
申请日：2016-04-27
IPC分类号： C11D3/386
CPC分类号： C11D3/38618 , C11D3/38627 , C11D3/38636 , C11D3/38645 , C11D11/0017 , C12Y301/21001 , C12Y301/30002 , C12Y302/01052
摘要： A method of treating a textile in which a textile is contacted with an aqueous solution comprising a nuclease enzyme, preferably a deoxyribonuclease or ribonuclease enzyme and low levels of alkyl benzene sulphonate surfactant, and optionally rinsing and drying the textile.
摘要翻译： 一种处理织物的方法，其中织物与包含核酸酶，优选脱氧核糖核酸酶或核糖核酸酶和低水平烷基苯磺酸盐表面活性剂的水溶液接触，以及任选地漂洗和干燥纺织品。
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