-
公开(公告)号：US10052081B2
公开(公告)日：2018-08-21
申请号：US15678789
申请日：2017-08-16
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Alaina Ann Brinley Rajagopal
CPC classification number: A61B7/04 , A61B5/0022 , A61B5/02055 , A61B5/021 , A61B5/0816 , A61B5/14532 , A61B5/14542 , A61B5/7253 , A61B5/7257 , A61B5/726 , A61B5/7264 , A61B5/742 , A61B8/02 , A61B8/06 , A61B8/085 , A61B8/4209 , A61B8/4416 , A61B8/4477 , A61B8/461 , A61B8/565 , A61B2560/0214 , G01S15/8952 , G01S15/899
Abstract: An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic sensors, and other sensors to obtain a series of measurements about a subject. The series of measurements may be correlated, such as by machine learning, to extract clinically relevant information. Also described are systems and methods for ultrasonic beamsteering by interference of an audio signal with an ultrasonic signal.
-
42.发明授权公开(公告)号：US09966443B2
公开(公告)日：2018-05-08
申请号：US14720473
申请日：2015-05-22
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SANOFI
Inventor： Aditya Rajagopal , Chieh-feng Chang , Oliver Plettenburg , Stefan Petry , Axel Scherer , Charles L. Tschirhart
IPC: H01L29/00 , H01L29/41 , H01L29/73 , H01L29/78 , B82Y15/00 , H01L29/732 , H01L29/06 , G01N27/414 , H01L29/45 , H01L29/49 , H01L29/735
CPC classification number: H01L29/413 , B82Y15/00 , G01N27/4145 , G01N27/4146 , H01L29/0676 , H01L29/45 , H01L29/49 , H01L29/73 , H01L29/732 , H01L29/735 , H01L29/78
Abstract: Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a functionalized layer contacted to either the base or the gate electrode. The functional layer can bind molecules, which causes an electrical signal in the sensor.
-
公开(公告)号：US20150057178A1
公开(公告)日：2015-02-26
申请号：US14451876
申请日：2014-08-05
Applicant: California Institute of Technology
Inventor： Emil Kartalov , Aditya Rajagopal , Axel Scherer
CPC classification number: G06F19/20 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/6486 , G06F17/10 , G06F17/11 , G06F19/12 , G06F19/24 , Y02A50/53 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
Abstract translation: 本公开提供了用于多个检测样品中多个分析物的方法，系统，组合物和试剂盒。 在一些实例中，本公开提供方法，系统，组合物和试剂盒，其中可以通过获取信号的至少一个可定量分量的累积测量或测量，在单个样品体积中检测多个分析物。 在某些情况下，信号的附加组件或附加信号（或其组件）也被量化。 信号的每个信号或分量可以用于构建编码方案，然后可以使用它来确定是否存在任何分析物。
-
公开(公告)号：US20130323716A1
公开(公告)日：2013-12-05
申请号：US13756760
申请日：2013-02-01
Applicant: California Institute of Technology
Inventor： Emil Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N21/64
CPC classification number: G06F19/20 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/6486 , G06F17/10 , G06F17/11 , G06F19/12 , G06F19/24 , Y02A50/53 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
-
公开(公告)号：US12102477B2
公开(公告)日：2024-10-01
申请号：US18128998
申请日：2023-03-30
Applicant: California Institute of Technology
Inventor： Alaina Ann Brinley Rajagopal , Aditya Rajagopal
CPC classification number: A61B8/0891 , A61B8/14 , A61B8/40 , A61B8/4236 , A61B8/4472 , G01S15/895
Abstract: An ultrasound measurement device includes: a processing device and multiple ultrasound sensors that capture tomographic information of a physiological structure. The ultrasound sensors include a first ultrasound sensor including a first transducer having a first frequency response with a first resonant frequency, and a second ultrasound sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits an ultrasound signal that is reflected by the physiological structure to create a reflected ultrasound signal, the first transducer generates a first received signal from the reflected ultrasound signal, the second transducer generates a second received signal from the reflected ultrasound signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.
-
Patent Agency Ranking
公开(公告)号：US11879162B2
公开(公告)日：2024-01-23
申请号：US17810696
申请日：2022-07-05
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC: C12P19/34 , C12Q1/70 , C12Q1/68 , C12Q1/6851
CPC classification number: C12Q1/701 , C12Q1/68 , C12Q1/6851 , C12Q1/703 , Y10T436/143333 , C12Q1/68 , C12Q2527/101 , C12Q2565/1015 , C12Q2565/133 , C12Q1/6851 , C12Q2561/113 , C12Q2565/101
Abstract: A non-transitory computer-readable storage medium storing executable instructions to cause a system to detect a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a measured change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
-
公开(公告)号：US20230038055A1
公开(公告)日：2023-02-09
申请号：US17958939
申请日：2022-10-03
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Emil P. Kartalov
Abstract: The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of kinetic signatures are provided. Further provided are methods and kits of nested PCR and PCR using limiting primers.
-
公开(公告)号：US20210363581A1
公开(公告)日：2021-11-25
申请号：US17125870
申请日：2020-12-17
Applicant: California Institute of Technology
Inventor： Emil P. Kartalov , Aditya Rajagopal , Axel Scherer , Mark D. Goldberg
IPC: C12Q1/6883 , C12Q1/68 , C12Q1/6851 , C12Q1/70
Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
-
公开(公告)号：US20210262083A1
公开(公告)日：2021-08-26
申请号：US17184567
申请日：2021-02-24
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal
Abstract: Methods for regulating and continuously monitoring a chemical synthesis reaction using micro-objects and electro-magnetic radiation include introducing micro-objects to a reaction mixture, determining a plasmon resonance of the micro-object based on a characteristic of the micro-object, and applying electro-magnetic radiation that is wavelength-matched to the plasmon resonance of the micro-object.
-
公开(公告)号：US20210002732A1
公开(公告)日：2021-01-07
申请号：US16827590
申请日：2020-03-23
Applicant: California Institute of Technology
Inventor： Aditya Rajagopal , Mark D. Goldberg , Erika F. Garcia , Xiomara L. Madero , Thomas A. Tombrello , Axel Scherer
IPC: C12Q1/70 , C12Q1/68 , C12Q1/6851
Abstract: Medical systems for detecting a genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, and the first primer and the second primer are specific for the polynucleotide analyte. The primers are configured to amplify the polynucleotide analyte having the genetic variation and a corresponding polynucleotide analyte lacking the generic variation. There is a detectable difference between a change in signal generated by the fluorophore and quencher, and measured by a sensor of the medical system, when using the first and second primers to amplify the polynucleotide analyte with the genetic variation, and a change in signal generated by the fluorophore and quencher, and measured by the sensor of the medical system, when using the first and second primers to amplify the corresponding polynucleotide analyte lacking the genetic variation.
-
-
-
-
-
-
-
-
-
Search Results
62
records
(took 0.025 seconds)
