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公开(公告)号：US20240344920A1
公开(公告)日：2024-10-17
申请号：US18685086
申请日：2022-08-22
Applicant: AMGEN INC.
Inventor： Al Patrick Goodwin , Joseph Peter Bermacki , Thomas Clark Pearson , Graham F. Milne , Jonathan Parsons , Corey Bishop , Barry Donohoe , Osvaldo Perez-Varela
CPC classification number: G01M3/38 , G01B11/2522 , G01N21/909 , G01N2201/0612
Abstract: An apparatus, system, or method for vial seal inspection may be based on three-dimensional data that is representative of at least a portion of a vial seal. More particularly, apparatuses, systems, and methods for vial seal inspection may include at least one laser triangulation sensor.
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公开(公告)号：US20240343832A1
公开(公告)日：2024-10-17
申请号：US18644757
申请日：2024-04-24
Applicant: AMGEN INC.
Inventor： JOON HOI HUH , RIKI STEVENSON , PAVEL BONDARENKO , ANDREW NICHOLS , DA REN , NEERAJ JAGDISH AGRAWAL , RICHARD SMITH
CPC classification number: C07K16/40 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/90 , C07K2317/92 , C07K2317/94 , G01N11/14
Abstract: The present invention concerns a method for preparing antigen binding proteins specific for PCSK9 with reduced viscosity. The method proceeds by replacing residues in high viscosity variable domain subfamilies with residues in correlating low viscosity subfamilies. The method further comprises substituting residues in the Fc domain with residues associated with low viscosity and adding charged residues to the C-terminus of the Fc domain. The present invention further concerns antigen binding proteins produced by this method.
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公开(公告)号：US20240336685A1
公开(公告)日：2024-10-10
申请号：US17281896
申请日：2019-09-27
Applicant: AMGEN INC.
Inventor： Bharadwaj Jagannathan , Joon Huh , Michael J. Treuheit , Daxian Shan
IPC: C07K16/28
CPC classification number: C07K16/2809 , C07K16/2803 , C07K16/2878 , C07K2317/10 , C07K2317/31
Abstract: The invention disclosed herein relates to methods for reducing aggregation of bispecific antibodies, for example reducing aggregation of bispecific T cell engager (BiTE) antibody constructs, resulting from storage under frozen conditions by holding the antibodies at certain temperatures after thaw.
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公开(公告)号：US20240327461A1
公开(公告)日：2024-10-03
申请号：US18497081
申请日：2024-06-11
Applicant: AMGEN INC.
Inventor： Jerry Ryan HOLDER , Gayathri SWAMINATH , Michael J. FROHN , Brian Alan LANMAN , Anthony B. REED , Leslie P. MIRANDA , John Gordon ALLEN , Alexander J. PICKRELL , Aaron C. SIEGMUND , Lewis D. PENNINGTON , Bryant YANG
CPC classification number: C07K7/08 , A61K38/10 , A61K47/542 , A61K47/60 , C07K14/47 , A61K38/00 , C07K2319/30
Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
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公开(公告)号：US12104995B2
公开(公告)日：2024-10-01
申请号：US16635941
申请日：2018-08-01
Applicant: AMGEN INC.
Inventor： Chao-Hsiang Wu
CPC classification number: G01N1/34 , G01N33/6848 , G01N2001/385
Abstract: Systems, and methods that facilitate the performance of an assay of a sample substantially in real-time. Thus, the assay can be performed, and the desired result obtained, much more quickly than allowed by conventional systems and methods.
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Patent Agency Ranking
公开(公告)号：US20240314190A1
公开(公告)日：2024-09-19
申请号：US18577109
申请日：2022-07-20
Applicant: AMGEN INC.
Inventor： Tyler Bellenfant , Jeremy S. Conner , Sarah Whetstone , Thomas Clark Pearson
IPC: H04L65/80 , H04N21/236 , H04N21/472 , H04N23/62 , H04N23/661
CPC classification number: H04L65/80 , H04N21/236 , H04N21/472 , H04N23/62 , H04N23/661
Abstract: A telepresence system may include at least one telepresence device including a digital camera having camera control inputs and a video feed output. The system may also include at least one remote device having a web browser. The camera control inputs may be communicated from the remote device to the at least one telepresence device via an embedded webserver. The video feed output may be communicated to the remote device via a video server configured to transmit real-time video data from the digital camera, over a secure socket connection, to the remote device.
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公开(公告)号：US12093304B2
公开(公告)日：2024-09-17
申请号：US17279803
申请日：2019-08-19
Applicant: AMGEN INC.
Inventor： Killian Ryan
IPC: G06F16/50 , G06F16/51 , G06F18/214 , G06F18/28 , G06T1/00 , G06T7/00 , G06V10/772 , H04N1/00 , H04N5/00
CPC classification number: G06F16/50 , G06F16/51 , G06F18/2148 , G06F18/28 , G06T1/0007 , G06T7/0004 , G06V10/772 , H04N1/00 , H04N1/0009 , H04N5/00 , G06T2207/20081 , G06T2207/20084 , G06V2201/06
Abstract: A method for sampling images includes receiving a first image set generated by automated imaging equipment during a first inspection period, and storing in a memory an image library that initially consists of the first image set. A plurality of new image sets is then sequentially received (302) during respective inspection periods. While the new image sets are received (302), the image library stored in the memory is updated. Updating the image library includes, for each new image set, adding to the image library a certain number of images distributed among the new image set and removing from the image library the same number of images distributed among a current instance of the image library (308). The number of overwritten images in the image library decreases from one inspection period to the next.
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公开(公告)号：US20240279704A1
公开(公告)日：2024-08-22
申请号：US18567747
申请日：2022-06-06
Applicant: AMGEN INC.
Inventor： Namratha SUBHASH , Yu Cong CHEN , Kyle Shamus MCELEARNEY , Glen BOLTON
CPC classification number: C12P21/005 , C07K1/22 , C07K1/34 , C07K16/244 , C12N9/2402 , C07K2317/14 , C07K2317/41 , C07K2317/72 , C12Y302/01051
Abstract: Provided herein are methods of obtaining a recombinant glycosylated protein having increased levels of afucosylated glycoforms. In exemplary embodiments, the methods comprise incubating purified recombinant glycosylated protein with a human broad specificity fucosidase and separating the recombinant glycosylated protein from the fucosidase.
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公开(公告)号：US20240277937A1
公开(公告)日：2024-08-22
申请号：US18645779
申请日：2024-04-25
Applicant: AMGEN INC.
Inventor： Adam B. McCullough , Basel Hasan Taha , Jimmie L. Ward , Christopher R. Folk , Steven William Badelt , Ferry Tamtoro , Huaying Yang , Mark Ka Lai Lee , Desheng Yin , Scott R. Gibson , Donald Busby , Peter V. Shultz , Keith P. Kogler
IPC: A61M5/20 , A61M5/142 , A61M5/158 , A61M5/24 , A61M5/315 , A61M5/32 , A61M5/50 , G06Q50/00 , G06Q50/22 , G16H20/17 , G16H40/00 , G16H40/63 , G16H40/67
CPC classification number: A61M5/20 , A61M5/14244 , A61M5/14248 , A61M5/158 , A61M5/24 , A61M5/31501 , A61M5/31568 , A61M5/3202 , A61M5/3243 , A61M5/3257 , A61M5/326 , A61M5/5086 , G06Q50/01 , G06Q50/22 , G16H20/17 , G16H40/00 , G16H40/63 , G16H40/67 , A61M2005/3267 , A61M2205/3331 , A61M2205/3368 , A61M2205/3553 , A61M2205/3576 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/6009
Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir, a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient, and one or more controllable elements. The drug delivery system may further include one or more sensors coupled to the drug delivery device, and a controller coupled to the one or more sensors and the one or more controllable elements. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device. Furthermore, the controller may be configured to control the controllable element based on the condition or the operational state of the drug delivery device and/or identity information stored in a memory onboard the device. A method for use with a drug delivery device is also disclosed.
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公开(公告)号：US20240271078A1
公开(公告)日：2024-08-15
申请号：US18567750
申请日：2022-06-06
Applicant: AMGEN INC.
Inventor： Jeremy S. Conner , Sarah Whetstone , Ketan Kumar
Abstract: A method of cell culture assessment (e.g., prior to a drug substance harvesting process) includes obtaining a plurality of parameters associated with a cell culture, and inferring or predicting a value or classification indicative of packed cell volume. Inferring or predicting the packed cell volume includes applying the plurality of parameters as inputs to a non-linear machine learning model. The method also includes generating an output indicative of the inferred or predicted value or classification.
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