公开(公告)号：US20240327461A1

公开(公告)日：2024-10-03

申请号：US18497081

申请日：2024-06-11

申请人： AMGEN INC.

发明人： Jerry Ryan HOLDER ,  Gayathri SWAMINATH ,  Michael J. FROHN ,  Brian Alan LANMAN ,  Anthony B. REED ,  Leslie P. MIRANDA ,  John Gordon ALLEN ,  Alexander J. PICKRELL ,  Aaron C. SIEGMUND ,  Lewis D. PENNINGTON ,  Bryant YANG

IPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  A61K47/54 ,  A61K47/60 ,  C07K14/47

CPC分类号： C07K7/08 ,  A61K38/10 ,  A61K47/542 ,  A61K47/60 ,  C07K14/47 ,  A61K38/00 ,  C07K2319/30

摘要： The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.

公开(公告)号：US20210261619A1

公开(公告)日：2021-08-26

申请号：US17160819

申请日：2021-01-28

申请人： AMGEN INC.

发明人： Jerry Ryan HOLDER ,  Gayathri SWAMINATH ,  Michael J. FROHN ,  Brian Alan LANMAN ,  Anthony B. REED ,  Leslie P. MIRANDA ,  John Gordon ALLEN ,  Alexander J. PICKRELL ,  Aaron C. SIEGMUND ,  Lewis D. PENNINGTON ,  Bryant YANG

IPC分类号： C07K7/08 ,  C07K14/47 ,  A61K47/54 ,  A61K47/60 ,  A61K38/10

摘要： The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.