公开(公告)号：US20250152838A1

公开(公告)日：2025-05-15

申请号：US19024450

申请日：2025-01-16

Applicant: AMGEN INC.

Inventor： Matias Melander ,  Joshua Jay Dudman ,  Joseph Michael Iglesias ,  Bjarke Lykke Ludvig Svendsen ,  Adam B. McCullough ,  Christian Plambech ,  Steve Sanchez

IPC: A61M5/315 ,  A61M5/20 ,  A61M5/32

Abstract: A drug delivery device includes a housing, an injection assembly at least partially disposed in the housing, a shield, and a drive assembly at least partially disposed in the housing and coupled with the injection assembly and the shield. The shield has an extended position where at least a proximal end thereof extends a distance beyond a proximal end of the housing. The injection assembly includes a needle or cannula having an endpoint. Upon moving the shield axially towards the distal end of the housing a predetermined distance, a retraction profile commences whereby the drive assembly administers a medicament via the injection assembly. A peak resistance force is exerted within approximately the first 12 mm of axial movement of the shield.

公开(公告)号：US20240245865A1

公开(公告)日：2024-07-25

申请号：US18410003

申请日：2024-01-11

Applicant: AMGEN INC.

Inventor： Adam B. McCullough

IPC: A61M5/315 ,  A61M5/00 ,  A61M5/142 ,  A61M5/145 ,  A61M5/158 ,  A61M5/168 ,  A61M5/20 ,  A61M5/50

CPC classification number: A61M5/31501 ,  A61M5/00 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/1454 ,  A61M5/20 ,  A61M5/2033 ,  A61M5/5086 ,  A61M2005/14252 ,  A61M5/14526 ,  A61M2005/1581 ,  A61M5/1684 ,  A61M5/16881 ,  A61M2005/2013 ,  A61M2005/2073 ,  A61M2205/13 ,  A61M2205/33 ,  A61M2205/3351 ,  A61M2205/50 ,  A61M2205/583 ,  A61M2205/8225

Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.

公开(公告)号：US11944794B2

公开(公告)日：2024-04-02

申请号：US16942733

申请日：2020-07-29

Applicant: AMGEN INC.

Inventor： Adam B. McCullough

IPC: A61M5/20 ,  A61M5/00 ,  A61M5/142 ,  A61M5/145 ,  A61M5/158 ,  A61M5/168 ,  A61M5/315 ,  A61M5/50

CPC classification number: A61M5/31501 ,  A61M5/00 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/1454 ,  A61M5/20 ,  A61M5/2033 ,  A61M5/5086 ,  A61M2005/14252 ,  A61M5/14526 ,  A61M2005/1581 ,  A61M5/1684 ,  A61M5/16881 ,  A61M2005/2013 ,  A61M2005/2073 ,  A61M2205/13 ,  A61M2205/33 ,  A61M2205/3351 ,  A61M2205/50 ,  A61M2205/583 ,  A61M2205/8225

Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.

公开(公告)号：US11517663B2

公开(公告)日：2022-12-06

申请号：US16782532

申请日：2020-02-05

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Lawrence S. Ring

IPC: A61M5/142 ,  A61M5/158 ,  A61M5/145

Abstract: A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.

公开(公告)号：US20220072224A1

公开(公告)日：2022-03-10

申请号：US17419450

申请日：2020-02-05

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Gregory Thomas Nowak

IPC: A61M5/152 ,  A61M5/168

Abstract: A drug delivery system includes a delivery container including a container body adapted to accommodate a drug therein, a supply line, and a flow rate monitor. The delivery container further includes inlet and outlet ports and is constructed from a resilient material. The container body is adapted to exert an urging force on the drug to expel the drug from the outlet port. The supply line is operably coupled to the outlet port to deliver the drug to a user. The flow rate monitor is operably coupled to at least one of the delivery container and the supply line. The flow rate monitor includes a flow rate sensor that senses a flow rate of the drug within the supply line.

公开(公告)号：US11207460B2

公开(公告)日：2021-12-28

申请号：US15775650

申请日：2016-12-14

Applicant: AMGEN INC.

Inventor： Ferry Tamtoro ,  Huaying Yang ,  Scott Robert Gibson ,  Donald Busby ,  Peter V. Shultz ,  Basel Hasan Taha ,  Adam B. McCullough

IPC: G06F17/00 ,  A61M5/00 ,  A61J7/04 ,  G16H20/17 ,  G16H40/63

Abstract: A drug delivery system includes a storage container defining one or more storage compartments and having at least one container sensor coupled thereto, a container condition change mechanism coupled to the storage container for imparting a change on one or more conditions of the one or more storage compartments, at least one drug delivery device adapted to deliver a drug to a user and adapted to be at least partially disposed within one or more of the one or more storage compartments, at least one delivery device sensor, a delivery device condition change mechanism coupled to the drug delivery device, and a controller coupled to the storage container. The storage container may be adapted to hold a number of drug delivery devices within a number of sealable storage compartments. The container sensor is adapted to sense a condition of the storage container, and the delivery device sensor is adapted to sense a condition of the at least one drug delivery device. The controller is adapted to instruct the container condition change mechanism and/or the delivery device change mechanism to impart a change on at least one condition of the storage container and/or the drug delivery device.

公开(公告)号：US10765801B2

公开(公告)日：2020-09-08

申请号：US15047853

申请日：2016-02-19

Applicant: AMGEN INC.

Inventor： Adam B. McCullough

IPC: A61M5/142 ,  A61M5/20 ,  A61M5/00 ,  A61M5/315 ,  A61M5/145 ,  A61M5/50 ,  A61M5/168 ,  A61M5/158

Abstract: A drug delivery device, in the form of an injector, may include one of a number of systems for limiting the delivery of a medical fluid or drug product in case of movement of (e.g., removal of) the injector relative to the patient as determined by a proximity sensor. The drug delivery system may in the alternative or in addition include systems for indicating the amount of medical fluid or drug product delivered (or not delivered) in case of movement of (e.g., removal of) the injector relative to the patient as determined by the proximity sensor. The injector may be, for example, an on-body injector or an hand-held autoinjector.

公开(公告)号：US10695492B2

公开(公告)日：2020-06-30

申请号：US15315817

申请日：2015-06-03

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Ferry Tamtoro ,  Huaying Yang ,  Mark Ka Lai Lee ,  Desheng Yin ,  Scott R. Gibson ,  Donald Busby ,  Peter V. Shultz ,  Keith P. Kogler ,  Jimmie L. Ward ,  Christopher R. Folk ,  Steven William Badelt

IPC: A61M5/50 ,  A61M5/20 ,  A61M5/315 ,  A61M5/32 ,  A61M5/142 ,  G06Q50/22 ,  G06F19/00 ,  G06Q50/00 ,  A61M5/158 ,  A61M5/24

Abstract: A drug delivery system is disclosed that includes a drug delivery device having a reservoir and a delivery cannula having a proximal end in fluid communication with the reservoir and a distal end to be received within a patient. The drug delivery system may further include one or more sensors coupled to the drug delivery device, a wireless transmitter, and a controller coupled to the one or more sensors and the wireless transmitter. The controller may be configured to use the one or more sensors to determine a condition or an operational state of the drug delivery device, and control the wireless transmitter to wirelessly transmit one or more reports representative of the condition or the operational state of the drug delivery device. A method for use with a drug delivery device is also disclosed.

公开(公告)号：US20200023122A1

公开(公告)日：2020-01-23

申请号：US16489833

申请日：2018-03-09

Applicant: AMGEN INC.

Inventor： Adam B. McCullough ,  Erich Coiner ,  Alan D. Payne

IPC: A61M5/142

Abstract: An insertion mechanism for a drug delivery device including a trocar, a housing, and a manifold in fluid communication with a fluid pathway connector and movable relative to the housing between a first manifold position adjacent to a proximal end of the housing and a second manifold position adjacent to a distal end of the housing. A hub carrying the trocar or hollow delivery needle is removably connected to the manifold, the hub being movable relative to the housing between a first hub position adjacent to the proximal end of the housing and a second hub position adjacent to the distal end of the housing. A power source is configured to generate rotational motion. A motion conversion mechanism operatively connects the power source and the hub, and is configured to convert the rotational motion into linear motion of the hub.

公开(公告)号：US20180318526A1

公开(公告)日：2018-11-08

申请号：US15775630

申请日：2016-12-09

Applicant: AMGEN INC.

Inventor： Huaying Yang ,  Desheng Yin ,  Ferry Tamtoro ,  Scott Robert Gibson ,  Keith P. Kogler ,  Michael Friedman ,  Neal Johnston ,  Adam B. McCullough

IPC: A61M5/50 ,  A61M5/24 ,  A61M5/32 ,  A61M5/20 ,  A61K38/19 ,  C07K16/40 ,  C07K14/705 ,  A61K38/17 ,  C07K16/28

CPC classification number: A61M5/5086 ,  A61K38/1793 ,  A61K38/193 ,  A61M5/2033 ,  A61M5/2466 ,  A61M5/3204 ,  A61M5/326 ,  A61M5/3286 ,  A61M2005/2086 ,  A61M2005/3104 ,  A61M2205/13 ,  A61M2205/14 ,  A61M2205/3368 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/36 ,  A61M2205/50 ,  A61M2205/581 ,  A61M2205/609 ,  A61M2205/8206 ,  A61M2205/8212 ,  C07K14/70578 ,  C07K16/2803 ,  C07K16/40 ,  C07K2317/31 ,  C07K2319/30 ,  G06F19/00 ,  G06F19/3468

Abstract: A drug delivery device includes a housing defining a shell, a drug delivery assembly at least partially disposed within the housing, a cap defining an opening and being adapted to at least partially cover an end of the housing, at least one electronic component, a power source which powers the electronic component, and a switch assembly. The drug delivery assembly comprises a guard which engages an inner surface of the housing and is movable between a first, a second, and a third position relative to the housing and are adapted to restrict external contact with a cannula. The switch assembly causes the power source to provide power to the electronic component when the cap is removed from the housing, restrict the power source from providing power when the cap is coupled to the housing and the guard is in the first position, and cause the power source to provide power when the cap is coupled to the housing and the guard is in the third position.