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    Drug delivery device with sterile fluid flowpath and related method of assembly
    1.
    发明授权
    Drug delivery device with sterile fluid flowpath and related method of assembly 有权

    公开(公告)号：US11752258B2

    公开(公告)日：2023-09-12

    申请号：US16485407

    申请日：2018-01-17

    申请人： AMGEN INC.

    发明人： Yasaman Damestani ,  Lawrence S. Ring

    IPC分类号： A61M5/145 ,  A61J1/20 ,  A61M5/24 ,  A61J1/14 ,  A61M5/28

    CPC分类号： A61M5/1456 ,  A61J1/2024 ,  A61M5/24 ,  A61J1/1406 ,  A61M5/285

    摘要： Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device.

    Drug delivery device with vacuum assisted securement and/or feedback
    3.
    发明授权
    Drug delivery device with vacuum assisted securement and/or feedback 有权

    公开(公告)号：US10583245B2

    公开(公告)日：2020-03-10

    申请号：US15544488

    申请日：2016-02-17

    申请人： AMGEN INC.

    发明人： Adam B. McCullough ,  Lawrence S. Ring

    IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M5/158

    摘要： A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.

    DRUG DELIVERY DEVICE WITH STERILE FLUID FLOWPATH AND RELATED METHOD OF ASSEMBLY
    5.
    发明公开
    DRUG DELIVERY DEVICE WITH STERILE FLUID FLOWPATH AND RELATED METHOD OF ASSEMBLY 审中-公开

    公开(公告)号：US20230372607A1

    公开(公告)日：2023-11-23

    申请号：US18226414

    申请日：2023-07-26

    申请人： AMGEN INC.

    发明人： Yasaman Damestani ,  Lawrence S. Ring

    IPC分类号： A61M5/145 ,  A61M5/24 ,  A61J1/20 ,  A61J1/14 ,  A61M5/28

    CPC分类号： A61M5/1456 ,  A61M5/24 ,  A61J1/2024 ,  A61J1/1406 ,  A61M5/285

    摘要： Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device.

    DRUG DELIVERY DEVICE WITH VACUUM ASSISTED SECUREMENT AND/OR FEEDBACK
    7.
    发明申请
    DRUG DELIVERY DEVICE WITH VACUUM ASSISTED SECUREMENT AND/OR FEEDBACK 审中-公开

    公开(公告)号：US20200171236A1

    公开(公告)日：2020-06-04

    申请号：US16782532

    申请日：2020-02-05

    申请人： AMGEN INC.

    发明人： Adam B. McCullough ,  Lawrence S. Ring

    IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M5/158

    摘要： A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.

    DRUG DELIVERY DEVICE WITH VACUUM ASSISTED SECUREMENT AND/OR FEEDBACK
    8.
    发明申请
    DRUG DELIVERY DEVICE WITH VACUUM ASSISTED SECUREMENT AND/OR FEEDBACK 审中-公开

    公开(公告)号：US20180036476A1

    公开(公告)日：2018-02-08

    申请号：US15544488

    申请日：2016-02-17

    申请人： AMGEN INC.

    发明人： Adam B. McCullough ,  Lawrence S. Ring

    IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M5/158

    摘要： A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.

    Drug delivery device with vacuum assisted securement and/or feedback
    10.
    发明授权
    Drug delivery device with vacuum assisted securement and/or feedback 有权

    公开(公告)号：US11517663B2

    公开(公告)日：2022-12-06

    申请号：US16782532

    申请日：2020-02-05

    申请人： AMGEN INC.

    发明人： Adam B. McCullough ,  Lawrence S. Ring

    IPC分类号： A61M5/142 ,  A61M5/158 ,  A61M5/145

    摘要： A drug delivery device includes a housing with at least one pressure communication channel or aperture, which distributes a negative fluid pressure across its base to draw tissue against the device. The device can also include a porous, adhesive layer over the channel(s) or aperture(s), for attaching to tissue. The device can also include a pressure sensor for determining whether there is proper attachment. Further, a bladder may be used instead of the adhesive layer for attaching the device. The bladder, in a partially inflated state, can apply constant pressure across a contact surface causing a flexible adhesive layer attached to the bladder to confirm and adhere to the tissue. Subsequent evacuation of the bladder causes it to deflate and collapse or retract, thereby causing the flexible adhesive layer to pull and stretch the tissue toward the base.