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    DESIGN AND SELECTION OF MEDICAMENTS THAT MODULATE THE FUNCTION AND ACTIVITY OF INTERLEUKIN 13
    32.
    发明申请
    DESIGN AND SELECTION OF MEDICAMENTS THAT MODULATE THE FUNCTION AND ACTIVITY OF INTERLEUKIN 13 有权
    设计和选择调节白细胞介素13的功能和活性的药物

    公开(公告)号：US20130281318A1

    公开(公告)日：2013-10-24

    申请号：US13921143

    申请日：2013-06-18

    Applicant: GLYCAN BIOSCIENCES LLC

    Inventor： Deirdre Roma COOMBE ,  Barbara MULLOY

    IPC: G01N33/68

    CPC classification number: G01N33/68 ,  A61K31/715 ,  A61K31/726 ,  A61K31/727 ,  C40B30/02 ,  G06F19/16 ,  G06F19/706 ,  Y02A90/26

    Abstract: The present invention relates generally to the field of medicaments in the form of therapeutic molecules including inflammatory modulators and their design and selection. More specifically, the present invention relates to a target site on Interleukin 13 (IL-13) by which a GAG molecule or polyanionic glycoconjugate or anionic polysaccharide modulates IL-13 activity or function, said target site selected from the list consisting of amino acids located in the AB loops and/or helix D of human IL-13 or its homolog or derivative, and the use of said IL-13 target site to design a medicament for modulating physiological processes. Therapeutic and prophylactic compositions comprising the designed medicaments are also contemplated.

    Abstract translation: 本发明一般涉及治疗分子形式的药物领域，包括炎症调节剂及其设计和选择。 更具体地，本发明涉及白细胞介素13（IL-13）上的靶位点，通过该靶位点GAG分子或聚阴离子糖缀合物或阴离子多糖调节IL-13活性或功能，所述靶位点选自位于 在人IL-13或其同源物或衍生物的AB环和/或螺旋D中，以及使用所述IL-13靶位点设计用于调节生理过程的药物。 还设想包含设计的药物的治疗和预防组合物。

    Crystal Structure of Amino Terminal Portion of Influenza Virus Polymerase PA Subunit and Use thereof
    33.
    发明申请
    Crystal Structure of Amino Terminal Portion of Influenza Virus Polymerase PA Subunit and Use thereof 审中-公开
    氨基末端部分流感病毒聚合酶PA亚基的晶体结构及其用途

    公开(公告)号：US20130046076A1

    公开(公告)日：2013-02-21

    申请号：US13254823

    申请日：2010-02-03

    Applicant: Yingfang Liu ,  Zihe Rao

    Inventor： Yingfang Liu ,  Zihe Rao

    IPC: C40B30/02 ,  C12N9/96 ,  C07K2/00 ,  C12N9/12

    CPC classification number: C07K14/005 ,  C07K2299/00 ,  C12N9/127 ,  C12N2760/16122 ,  C12N2760/16222 ,  C12N2760/16322 ,  C40B30/02 ,  G06F19/16 ,  G06F19/706

    Abstract: Present invention disclosed three-dimensional crystal structure of N-terminus polypeptide of influenza virus polymerase subunit (PA_N). PA_N is residues 1˜50 to 150˜300 of influenza virus polymerase subunit PA. In three-dimensional structure, at least 40% of atoms showed same atomic coordinates, compared to that listed in Table. In other words, in three-dimensional structure of influenza virus polymerase subunit PA_N, 40% of atomic coordinates on carbon skeleton of residues of influenza virus polymerase subunit PA_N, showed less than or equal to 1.7 Å of average variance, compared to the atomic coordinates listed in Table1. Present invention also disclosed the expression, purification, crystallization methods, and three-dimensional crystal structure of 256 residues in the N-terminus of influenza virus polymerase subunit PA, and applications of the crystal structure on drug screening and designing.

    Abstract translation: 本发明公开了流感病毒聚合酶亚基（PA_N）的N末端多肽的三维晶体结构。 PA_N是流感病毒聚合酶亚基PA的残基1〜50〜150〜300。 在三维结构中，与表中列出的相比，至少40％的原子显示相同的原子坐标。 换句话说，在流感病毒聚合酶亚基PA_N的三维结构中，流感病毒聚合酶亚基PA_N残基的碳骨架上的原子坐标的40％显示平均差异小于或等于1.7的原子坐标 列于表1。 本发明还公开了流感病毒聚合酶亚基PA的N末端中256个残基的表达，纯化，结晶方法和三维晶体结构，以及晶体结构在药物筛选和设计中的应用。

    Systems and methods for engineering nucleic acid constructs using scoring techniques
    34.
    发明授权
    Systems and methods for engineering nucleic acid constructs using scoring techniques 有权
    使用评分技术设计核酸构建体的系统和方法

    公开(公告)号：US08332160B1

    公开(公告)日：2012-12-11

    申请号：US13442625

    申请日：2012-04-09

    Applicant: Darren M. Platt ,  Michael W. Bissell ,  Sunil S. Chandran ,  Brian L. Hawthorne ,  Erik Jedediah Dean ,  Christopher Dolan

    Inventor： Darren M. Platt ,  Michael W. Bissell ,  Sunil S. Chandran ,  Brian L. Hawthorne ,  Erik Jedediah Dean ,  Christopher Dolan

    IPC: G06F19/00 ,  G06F15/00 ,  G11C17/00 ,  G01N33/48

    CPC classification number: C40B30/02 ,  G06F19/22

    Abstract: Systems and methods are provided for defining a nucleic acid construct for integration at locus L of an organism. Nucleic acid requests are received, each such request specifying a genetic change to L. The request are expanded into component polynucleotides which are then arranged into {AR1, . . . , ARm} different arrangements, each ARi in {AR1, . . . , ARm} defining a different arrangement of the component polynucleotides. A score Si for each ARi in {AR1, . . . , ARm} is determined based on whether source constructs encoding a portion ofARi are physically present. An ARf in {AR1, . . . , ARm} is selected based on the score for ARf. Primer pairs are calculated to amplify the portions of ARf not represented in the source constructs. The portions of ARf amplified by the primer pairs and the portions of ARf in the source constructs, ordered by ARf, define the nucleic acid construct.

    Abstract translation: 提供了用于定义用于在生物体的基因座L处整合的核酸构建体的系统和方法。 接收核酸请求，每个这样的请求指定对L的遗传变化。该请求被扩展成组分多核苷酸，然后将其排列成{AR1，...。 。 。 ，ARm}不同的安排，每个ARi在{AR1，。 。 。 ，ARm}定义组分多核苷酸的不同排列。 每个ARi在{AR1，。 。 。 ARm}是基于是否存在编码一部分的ARi的源结构来确定的。 {AR1，。 。 。 ，ARm}根据ARf的得分进行选择。 计算引物对以扩增源结构中未表示的部分ARf。 通过引物对扩增的ARf的部分和由ARf排序的源结构中的ARf的部分定义了核酸构建体。

    SYSTEM AND APPARATUS FOR THE REMOTE ANALYSIS OF CHEMICAL COMPOUND MICROARRAYS
    35.
    发明申请
    SYSTEM AND APPARATUS FOR THE REMOTE ANALYSIS OF CHEMICAL COMPOUND MICROARRAYS 有权
    化学复合微波远程分析的系统和装置

    公开(公告)号：US20120201437A1

    公开(公告)日：2012-08-09

    申请号：US13369100

    申请日：2012-02-08

    Applicant: Peter Ohnemus

    Inventor： Peter Ohnemus

    IPC: G06K9/00

    CPC classification number: C40B30/02 ,  G06F19/20 ,  G06F19/709 ,  G06T7/0012 ,  G06T2207/10024 ,  G06T2207/30072 ,  H04N1/6033

    Abstract: A remote microarray analysis system, method and apparatus for use in the remote analysis of a chemical compound microarray supported on a substrate is disclosed. Pixel image data is received from a remote location including image data that depicts (a) a calibration scale associated with the substrate and (b) the microarray. A transformation action of said pixel data corresponding to the calibration scale is determined and the received image data corresponding to at least the microarray is adjusted by applying the transformation action. The adjusted image of the microarray is compared with a database of stored microarray pixel data to extract information from said image.

    Abstract translation: 公开了用于远程分析支撑在基板上的化合物微阵列的远程微阵列分析系统，方法和装置。 从远程位置接收像素图像数据，包括描绘（a）与衬底相关联的校准标度的图像数据和（b）微阵列。 确定与校准标尺相对应的所述像素数据的变换动作，并且通过应用变换动作来调整对应于至少微阵列的接收图像数据。 将微阵列的调整图像与存储的微阵列像素数据的数据库进行比较，以从所述图像提取信息。

    COMPETITIVE INHIBITORS OF INVARIANT CHAIN EXPRESSION AND/OR ECTOPIC CLIP BINDING
    38.
    发明申请
    COMPETITIVE INHIBITORS OF INVARIANT CHAIN EXPRESSION AND/OR ECTOPIC CLIP BINDING 有权
    不连续链表达式和/或ECTOPIC CLIP BINDING的竞争性抑制剂

    公开(公告)号：US20110118175A1

    公开(公告)日：2011-05-19

    申请号：US12739459

    申请日：2008-10-23

    Applicant: Martha Karen Newell ,  Evan Newell

    Inventor： Martha Karen Newell ,  Evan Newell

    IPC: A61K38/10 ,  C07K7/06 ,  C07K7/08 ,  A61K38/08 ,  A61P31/12 ,  A61P33/00

    CPC classification number: A61K38/08 ,  A61K38/00 ,  A61K39/0011 ,  C07K7/06 ,  C40B30/02 ,  G06F19/16 ,  G06F19/18 ,  Y02A50/401 ,  Y02A50/409 ,  Y02A50/411

    Abstract: The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, cancer, Alzheimer's disease, allergic disease, transplant and cell graft rejection, HIV infection and other viral, bacterial, and parasitic infection, and AIDS. Methods are also provided for preparing a peptide having the property of being able to displace CLIP by feeding one or more peptide sequences into software that predicts MHC Class II binding regions in an antigen sequence and related products.

    Abstract translation: 本发明涉及通过靶向CLIP分子调节免疫功能的方法。 其结果是广泛的新的治疗方案，用于治疗，抑制多种疾病和病症的发展或以其他方式处理，包括自身免疫疾病，癌症，阿尔茨海默氏病，过敏性疾病，移植和细胞移植排斥，HIV感染和 其他病毒，细菌和寄生虫感染以及艾滋病。 还提供了用于制备具有能够通过将一个或多个肽序列加入到预测抗原序列中的MHC II类结合区的相关产品的软件中来取代CLIP的性质的方法。

    Methods for Classification of Toxic Agents and Counteragents
    39.
    发明申请
    Methods for Classification of Toxic Agents and Counteragents 有权
    有毒物和反夹具分类方法

    公开(公告)号：US20100235104A1

    公开(公告)日：2010-09-16

    申请号：US12594192

    申请日：2008-03-28

    Applicant: Ellen L. Berg

    Inventor： Ellen L. Berg

    IPC: G06F19/00

    CPC classification number: C40B30/02 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24

    Abstract: Methods and systems for evaluating biological dataset profiles relating to toxic agents including candidate pharmaceuticals, environmental agents, biowarfare and chemical warfare agents are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate agents.

    Abstract translation: 提供了用于评估与包括候选药物，环境代理，生物武器和化学战剂在内的有毒物质有关的生物数据集概况的方法和系统，其中比较和识别包括多个细胞参数的信息的数据集，并用于评估候选药剂。

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