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公开(公告)号：US08762066B2
公开(公告)日：2014-06-24
申请号：US11981578
申请日：2007-10-30
申请人： Richard John Fox
发明人： Richard John Fox
CPC分类号： G06F19/18 , C12N15/1058 , C40B30/02 , C40B50/02 , G01N33/6818 , G06F17/50 , G06F19/22 , G06F19/24 , G06N99/005
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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公开(公告)号：US07783428B2
公开(公告)日：2010-08-24
申请号：US10379378
申请日：2003-03-03
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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3.发明授权公开(公告)号：US08849575B2
公开(公告)日：2014-09-30
申请号：US11429628
申请日：2006-05-05
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US20120208259A1
公开(公告)日：2012-08-16
申请号：US13349514
申请日：2012-01-12
申请人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
发明人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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5.发明申请公开(公告)号：US20110161265A1
公开(公告)日：2011-06-30
申请号：US12979637
申请日：2010-12-28
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US07751986B2
公开(公告)日：2010-07-06
申请号：US11981577
申请日：2007-10-30
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin A. Emig , Richard John Fox , Ajoy K. Roy , Jeremy S. Minshull , S. Christopher Davis , Anthony R. Cox , Phillip A. Patten , Linda A. Castle , Daniel L. Siehl , Rebecca Lynne Gorton , Teddy Chen
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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公开(公告)号：US20100167345A1
公开(公告)日：2010-07-01
申请号：US12573824
申请日：2009-10-05
申请人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
发明人： S. Christopher Davis , Richard John Fox , Gjalt W. Huisman , Vesna Gavrilovic , Lisa Marie Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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公开(公告)号：US20100005047A1
公开(公告)日：2010-01-07
申请号：US12557469
申请日：2009-09-10
申请人： Richard John Fox
发明人： Richard John Fox
CPC分类号： G16B20/00 , C12N15/1058 , G01N33/6818 , G06F17/50 , G06N20/00 , G16B30/00 , G16B35/00 , G16B40/00 , G16C20/60
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
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9.发明申请公开(公告)号：US20100004135A1
公开(公告)日：2010-01-07
申请号：US12557465
申请日：2009-09-10
申请人： Richard John Fox
发明人： Richard John Fox
IPC分类号： C40B30/02
CPC分类号： G16B20/00 , C12N15/1058 , G01N33/6818 , G06F17/50 , G06N20/00 , G16B30/00 , G16B35/00 , G16B40/00 , G16C20/60
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译： 本发明一般涉及快速有效地搜索生物相关数据空间的方法。 更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。 本发明还提供了对序列活性关系建模的方法。 由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。
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公开(公告)号：US08252554B2
公开(公告)日：2012-08-28
申请号：US12505374
申请日：2009-07-17
申请人： S. Christopher Davis , Lisa Marie Newman , Vesna Gavrilovic , Gjalt W. Huisman , Richard John Fox , Emily C. Mundorff
发明人： S. Christopher Davis , Lisa Marie Newman , Vesna Gavrilovic , Gjalt W. Huisman , Richard John Fox , Emily C. Mundorff
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
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