公开(公告)号：US20160303243A1

公开(公告)日：2016-10-20

申请号：US15148206

申请日：2016-05-06

Applicant: GLYCAN BIOSCIENCES LLC

Inventor： WARREN CHARLES KETT ,  YUGANG CHEN

IPC: A61K47/48 ,  A61K31/7056 ,  A61K31/7036

CPC classification number: A61K47/4823 ,  A61K31/702 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7056 ,  A61K47/549 ,  A61K47/61 ,  C07H3/06 ,  C07H5/06 ,  C07H5/10 ,  C07H13/12 ,  C07H15/14 ,  C07H15/203 ,  C07H15/224 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/236 ,  C07H15/238 ,  C07H15/26 ,  C07H19/056

Abstract: The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.

Abstract translation: 本发明涉及可用于模拟称为糖胺聚糖（GAG）的阴离子生物活性分子的结构和/或活性的糖基化细菌代谢物的阴离子缀合物。 本发明还涉及制备缀合物的方法。 这样的缀合物可用于预防和/或治疗疾病状况，特别是慢性疾病病症，例如炎症（包括过敏性）疾病，转移性癌症和包括细菌，病毒或寄生虫在内的病原体感染。

公开(公告)号：US20210386770A1

公开(公告)日：2021-12-16

申请号：US16341777

申请日：2017-10-12

Applicant: Glycan Biosciences LLC

Inventor： Alan David Payne ,  Bruno Basic ,  Shifaza Mohamed ,  Deirdre Roma Coombe

IPC: A61K31/7056 ,  A61K47/54 ,  A61K31/7034 ,  A61P29/00

Abstract: The present invention relates generally to the field of glycanics and its application to the generation of glycoconjugates for therapeutic use. The present invention also relates to process for the preparation of glycoconjugates.

公开(公告)号：US20130281318A1

公开(公告)日：2013-10-24

申请号：US13921143

申请日：2013-06-18

Applicant: GLYCAN BIOSCIENCES LLC

Inventor： Deirdre Roma COOMBE ,  Barbara MULLOY

IPC: G01N33/68

CPC classification number: G01N33/68 ,  A61K31/715 ,  A61K31/726 ,  A61K31/727 ,  C40B30/02 ,  G06F19/16 ,  G06F19/706 ,  Y02A90/26

Abstract: The present invention relates generally to the field of medicaments in the form of therapeutic molecules including inflammatory modulators and their design and selection. More specifically, the present invention relates to a target site on Interleukin 13 (IL-13) by which a GAG molecule or polyanionic glycoconjugate or anionic polysaccharide modulates IL-13 activity or function, said target site selected from the list consisting of amino acids located in the AB loops and/or helix D of human IL-13 or its homolog or derivative, and the use of said IL-13 target site to design a medicament for modulating physiological processes. Therapeutic and prophylactic compositions comprising the designed medicaments are also contemplated.

Abstract translation: 本发明一般涉及治疗分子形式的药物领域，包括炎症调节剂及其设计和选择。 更具体地，本发明涉及白细胞介素13（IL-13）上的靶位点，通过该靶位点GAG分子或聚阴离子糖缀合物或阴离子多糖调节IL-13活性或功能，所述靶位点选自位于 在人IL-13或其同源物或衍生物的AB环和/或螺旋D中，以及使用所述IL-13靶位点设计用于调节生理过程的药物。 还设想包含设计的药物的治疗和预防组合物。

公开(公告)号：US09964543B2

公开(公告)日：2018-05-08

申请号：US13921143

申请日：2013-06-18

Applicant: GLYCAN BIOSCIENCES LLC

Inventor： Deirdre Roma Coombe ,  Barbara Mulloy

IPC: G01N33/68 ,  A61K31/715 ,  A61K31/726 ,  A61K31/727 ,  C40B30/02 ,  G06F19/16 ,  G06F19/00

CPC classification number: G01N33/68 ,  A61K31/715 ,  A61K31/726 ,  A61K31/727 ,  C40B30/02 ,  G06F19/16 ,  G06F19/706 ,  Y02A90/26

Abstract: Medicaments in the form of therapeutic molecules including inflammatory modulators are designed and selected. A target site is on Interleukin 13 (IL-13) in which a glycosaminoglycan (GAG) molecule or polyanionic glycoconjugate or anionic polysaccharide modulates IL-13 activity or function. The target site can include amino acids located in the AB loops and/or helix D of human IL-13 or its homolog or derivative. The IL-13 target site is used to design a medicament for modulating physiological processes. Therapeutic and prophylactic compositions can include the designed medicaments.

公开(公告)号：US09346845B2

公开(公告)日：2016-05-24

申请号：US14328155

申请日：2014-07-10

Applicant: GLYCAN BIOSCIENCES LLC

Inventor： Warren Charles Kett ,  Yugang Chen

IPC: A61K31/7036 ,  C07H15/23 ,  C07H15/232 ,  C07H15/224 ,  C07H15/234 ,  C07H15/238 ,  A61K31/702 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7056 ,  C07H3/06 ,  C07H5/06 ,  C07H5/10 ,  C07H13/12 ,  C07H15/14 ,  C07H15/203 ,  C07H15/26 ,  C07H19/056 ,  C07H15/236

CPC classification number: A61K47/4823 ,  A61K31/702 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7056 ,  A61K47/48092 ,  A61K47/549 ,  A61K47/61 ,  C07H3/06 ,  C07H5/06 ,  C07H5/10 ,  C07H13/12 ,  C07H15/14 ,  C07H15/203 ,  C07H15/224 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/236 ,  C07H15/238 ,  C07H15/26 ,  C07H19/056

Abstract: The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.

Abstract translation: 本发明涉及可用于模拟称为糖胺聚糖（GAG）的阴离子生物活性分子的结构和/或活性的糖基化细菌代谢物的阴离子缀合物。 本发明还涉及制备缀合物的方法。 这样的缀合物可用于预防和/或治疗疾病状况，特别是慢性疾病病症，例如炎症（包括过敏性）疾病，转移性癌症和包括细菌，病毒或寄生虫在内的病原体感染。

公开(公告)号：US20140323422A1

公开(公告)日：2014-10-30

申请号：US14328155

申请日：2014-07-10

Applicant: GLYCAN BIOSCIENCES LLC

Inventor： Warren Charles KETT ,  Yugang CHEN

IPC: C07H15/238 ,  A61K31/7036 ,  C07H15/23 ,  C07H15/236 ,  C07H15/232 ,  C07H15/224

CPC classification number: A61K47/4823 ,  A61K31/702 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/7056 ,  A61K47/48092 ,  A61K47/549 ,  A61K47/61 ,  C07H3/06 ,  C07H5/06 ,  C07H5/10 ,  C07H13/12 ,  C07H15/14 ,  C07H15/203 ,  C07H15/224 ,  C07H15/23 ,  C07H15/232 ,  C07H15/234 ,  C07H15/236 ,  C07H15/238 ,  C07H15/26 ,  C07H19/056

Abstract: The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.

Abstract translation: 本发明涉及可用于模拟称为糖胺聚糖（GAG）的阴离子生物活性分子的结构和/或活性的糖基化细菌代谢物的阴离子缀合物。 本发明还涉及制备缀合物的方法。 这样的缀合物可用于预防和/或治疗疾病状况，特别是慢性疾病病症，例如炎症（包括过敏性）疾病，转移性癌症和包括细菌，病毒或寄生虫在内的病原体感染。