公开(公告)号：US20140074159A1

公开(公告)日：2014-03-13

申请号：US14074869

申请日：2013-11-08

Applicant: Joseph Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick ,  Richard C. Svrluga

Inventor： Joseph Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: D06M10/00 ,  A61L17/14 ,  A61L2/00

CPC classification number: D06M10/00 ,  A61B17/06166 ,  A61B2017/00526 ,  A61B2017/00884 ,  A61F2/30767 ,  A61F2/30771 ,  A61F2002/30031 ,  A61F2002/3084 ,  A61F2002/3093 ,  A61F2310/00976 ,  A61L2/007 ,  A61L17/10 ,  A61L17/14 ,  A61L17/145 ,  A61L2400/18 ,  B29C59/16 ,  B29C2035/0872 ,  C03C15/02 ,  C03C23/00 ,  C30B29/20 ,  C30B33/04 ,  D06M10/008 ,  D06M10/04 ,  D06M16/00 ,  C08L23/06 ,  C08L67/02

Abstract: A method for improving bioactivity of a surface of a surgical suture and sutures prepared thereby provides forming a gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing a surgical suture into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said surgical suture with a GLIB derived beam.

Abstract translation: 用于改善手术缝合线的表面的生物活性的方法和由此制备的缝合线提供了在减压室中形成气体簇离子束（GCIB），将外科缝合线引入减压室中，并且至少照射 所述手术缝合线的表面的第一部分具有GLIB导出的束。

公开(公告)号：US20130213933A1

公开(公告)日：2013-08-22

申请号：US13590405

申请日：2012-08-21

Applicant: Sean R. Kirkpatrick ,  Allen R. Kirkpatrick

Inventor： Sean R. Kirkpatrick ,  Allen R. Kirkpatrick

IPC: G01N23/00

CPC classification number: G01N23/00 ,  G01N23/225 ,  H01J37/08 ,  H01J37/305 ,  H01J2237/0041 ,  H01J2237/0812 ,  H01J2237/3151

Abstract: Apparatus and methods are disclosed for employing an accelerated neutral beam derived from an accelerated gas cluster ion beam as a physical etching beam for providing reduced material mixing at the etched surface, compared to previous techniques. This results in the ability to achieve improved depth profile resolution in measurements by analytical instruments such as SIMS and XPS (or ESCA) analytical instruments.

Abstract translation: 公开了用于采用从加速气体团簇离子束衍生的加速中性束作为物理蚀刻光束的设备和方法，用于在蚀刻表面提供减少的材料混合，与先前的技术相比。 这样就可以通过SIMS和XPS（或ESCA）分析仪器等分析仪器在测量中实现改进的深度分布分辨率。

公开(公告)号：US20130024004A1

公开(公告)日：2013-01-24

申请号：US13358151

申请日：2012-01-25

Applicant: Joseph Khoury ,  Sean R. Kirkpatrick

Inventor： Joseph Khoury ,  Sean R. Kirkpatrick

IPC: A61L2/08 ,  A61F2/02

CPC classification number: C12N13/00 ,  A61L2/007 ,  A61L2202/21

Abstract: A method of disinfecting a biological material provides disposing at least a portion of the biological material in the path of the gas cluster ion beam or in the path of the accelerated neutral beam so as to irradiate at least a portion of the biological material to disinfect the irradiated portion.

Abstract translation: 消毒生物材料的方法提供了在气体簇离子束的路径中或在加速中性束的路径中设置生物材料的至少一部分，以便照射至少一部分生物材料以对 照射部分。

公开(公告)号：US20110029068A1

公开(公告)日：2011-02-03

申请号：US12851161

申请日：2010-08-05

Applicant: Sean R. Kirkpatrick ,  Richard C. Svrluga

Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: A61L27/54 ,  B05D3/06 ,  C23C14/02 ,  G21G5/00

CPC classification number: C23C14/022 ,  A61F2/82 ,  A61F2250/0067 ,  C23C14/221 ,  C23C14/505 ,  H01J37/3171 ,  H01J2237/0812

Abstract: Irradiation of a surface of a material with a gas cluster ion beam modifies the wettability of the surface. The wettability may be increased or decreased dependent on the characteristics of the gas cluster ion beam. Improvements in wettability of a surface by the invention exceed those obtained by conventional plasma cleaning or etching. The improvements may be applied to surfaces of medical devices, such as vascular stents for example, and may be used to enable better wetting of medical device surfaces with liquid drugs in preparation for adhesion of the drug to the device surfaces. A mask may be used to limit processing to a portion of the surface. Medical devices formed by using the methods of the invention are disclosed.

Abstract translation: 用气体簇离子束照射材料的表面改变了表面的润湿性。 根据气体簇离子束的特性，润湿性可以增加或减少。 通过本发明的表面润湿性的改善超过了通过常规等离子体清洗或蚀刻获得的那些。 这些改进可以应用于诸如血管支架的医疗装置的表面，并且可以用于使液体药物更好地润湿医疗装置表面，以准备将药物粘附到装置表面。 可以使用掩模来将处理限制到表面的一部分。 公开了通过使用本发明的方法形成的医疗装置。

公开(公告)号：US20100227523A1

公开(公告)日：2010-09-09

申请号：US12722471

申请日：2010-03-11

Applicant: Joseph Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick ,  Richard C. Svrluga

Inventor： Joseph Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: D04H13/00 ,  H01J37/317 ,  A61F2/02 ,  C22C14/00 ,  C03C3/00 ,  C08F110/06 ,  C08F112/08 ,  C01B33/12

CPC classification number: G06F17/3074 ,  A61B2017/00969 ,  A61F2/0077 ,  A61F2/30767 ,  B29C59/16 ,  B29C2035/0872 ,  D06M10/00 ,  D06M10/008 ,  D06M10/04 ,  G06F16/60 ,  H01J2237/0812 ,  H01J2237/2505 ,  Y10T442/60

Abstract: The invention provide for a method of improving bioactivity of a surface of an object. The invention further provides for a method of preparing an object for medical implantation. The invention even further provide for an article made by a method comprising the steps of forming a gas-cluster ion-beam in a reduced-pressure chamber, introducing the article into the reduced-pressure chamber, and irradiating at least a portion of the surface of the object with the gas-cluster ion-beam. The invention still further provides for an article for medical or surgical implantation made by a method comprising selecting at least a portion of a surface of the object for increased bioactivity, forming a gas-cluster ion-beam in a reduced-pressure chamber, introducing the object into the reduced-pressure chamber, and irradiating the selected at least a portion with the gas-cluster ion-beam to increase the bioactivity of the at least a portion.

Abstract translation: 本发明提供了改善物体表面生物活性的方法。 本发明还提供了一种制备用于医学植入的物体的方法。 本发明甚至进一步提供了一种通过包括以下步骤的方法制备的制品：在减压室中形成气体簇离子束，将制品引入减压室中，并且照射表面的至少一部分 的物体与气体簇离子束。 本发明还进一步提供一种用于医疗或手术植入的制品，该制品通过包括选择物体的表面的至少一部分以增加生物活性，在减压室中形成气体簇离子束，引入 物体进入减压室，并且用气体簇离子束照射所选择的至少一部分以增加至少一部分的生物活性。

公开(公告)号：US20100226897A1

公开(公告)日：2010-09-09

申请号：US12722126

申请日：2010-03-11

Applicant: Joseph Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick ,  Richard C. Svrluga

Inventor： Joseph Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: A61K35/12

CPC classification number: A61F2/30771 ,  A61B2017/00969 ,  A61F2/0077 ,  A61F2/08 ,  A61F2/30767 ,  A61F2/4644 ,  A61L27/3604 ,  A61L27/3691 ,  A61L27/38 ,  A61L2430/10 ,  A61L2430/40 ,  H01J2237/0812 ,  H01J2237/20207 ,  H01J2237/20214

Abstract: The invention provides methods for surgical grafting of a tissue. The method comprises the steps of explanting a graft tissue from a donor, irradiating at least a first portion of the graft tissue with an ion beam, and surgically grafting the graft tissue into a recipient.

Abstract translation: 本发明提供了用于组织外科移植的方法。 该方法包括以下步骤：从供体移出移植物组织，用离子束照射移植组织的至少第一部分，以及将移植物组织手术移植到受体中。

公开(公告)号：US20090098186A1

公开(公告)日：2009-04-16

申请号：US12243285

申请日：2008-10-01

Applicant: Sean R. Kirkpatrick ,  Richard C. Svrluga

Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga

IPC: A61K9/70 ,  B05D3/00 ,  A61P43/00 ,  C23C16/54

CPC classification number: B05D1/02 ,  A61F2/82 ,  A61F2240/001 ,  B05B5/08 ,  B05D3/0493 ,  B05D3/06 ,  B05D3/107 ,  B05D3/145 ,  H01J37/3053 ,  H01J2237/0812 ,  H01J2237/3151

Abstract: A multi-layer drug coated medical device such as for example an expandable vascular drug eluting stent is formed by vacuum pulse spray techniques wherein each layer is irradiated to improve adhesion and/or drug elution properties prior to formation of subsequent layers. Layers may be homogeneous or of diverse drugs. Layers may incorporate a non-polymer elution-retarding material. Layers may alternate with one or more layers of non-polymer elution-retarding materials. Polymer binders and/or matrices are not used in the formation of the coatings, yet the pure drug coatings have good mechanical and elution rate properties. Systems, methods and medical device articles are disclosed.

Abstract translation: 通过真空脉冲喷雾技术形成多层药物涂覆的医疗装置，例如可扩张血管药物洗脱支架，其中每层照射以在形成后续层之前提高粘附性和/或药物洗脱性质。 层可能是同质的或不同的药物。 层可以掺入非聚合物洗脱阻滞材料。 层可以与一层或多层非聚合物洗脱阻滞材料交替。 聚合物粘合剂和/或基质不用于形成涂层，而纯药物涂层具有良好的机械和洗脱速率性能。 公开了系统，方法和医疗装置的物品。

公开(公告)号：US10342900B2

公开(公告)日：2019-07-09

申请号：US13591837

申请日：2012-08-22

Applicant: Richard C. Svrluga ,  Sean R. Kirkpatrick ,  Stephen M. Blinn

Inventor： Richard C. Svrluga ,  Sean R. Kirkpatrick ,  Stephen M. Blinn

IPC: A61L31/16 ,  A61L27/54 ,  A61K31/436

Abstract: A method of modifying the surface of a medical device to release a drug in a controlled way by providing a barrier layer on the surface of one or more drug coatings. The barrier layer consists of modified drug material converted to a barrier layer by irradiation by an accelerated neutral beam derived from an accelerated gas cluster ion beam. Also medical devices formed thereby.

公开(公告)号：US20190137868A1

公开(公告)日：2019-05-09

申请号：US16239272

申请日：2019-01-03

Applicant: Joseph B. Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick

Inventor： Joseph B. Khoury ,  Laurence B. Tarrant ,  Sean R. Kirkpatrick

IPC: G03F1/80 ,  H01L21/265 ,  H01J37/05 ,  H01J37/317 ,  H01L21/311 ,  H01L21/02 ,  G03F1/82 ,  H05H3/02 ,  H01J37/147

Abstract: A method for preparing a biological material for implanting provides irradiating at least a portion of the surface of the material with an accelerated Neutral Beam.

公开(公告)号：US20180090295A1

公开(公告)日：2018-03-29

申请号：US15826445

申请日：2017-11-29

Applicant: Sean R. Kirkpatrick ,  Richard C. Svrluga ,  Stephen M. Blinn

Inventor： Sean R. Kirkpatrick ,  Richard C. Svrluga ,  Stephen M. Blinn

IPC: H01J37/05 ,  H05H3/02 ,  H01J37/317 ,  H01J37/147

CPC classification number: H01J37/05 ,  H01J37/147 ,  H01J37/317 ,  H01J37/3171 ,  H01J2237/0041 ,  H01J2237/0812 ,  H01J2237/15 ,  H05H1/20 ,  H05H3/02 ,  Y10T428/24355 ,  Y10T428/24479 ,  Y10T428/30

Abstract: An apparatus and method provided a drug layer formed on a surface region of a medical device, the drug layer comprised of a drug deposition and a carbonized or densified layer formed from the drug deposition by irradiation on an outer surface of the drug deposition, wherein the carbonized or densified layer does not penetrate through the drug deposition and is adapted to release drug from the drug deposition at a predetermined rate.