公开(公告)号：US20150222092A1

公开(公告)日：2015-08-06

申请号：US14690198

申请日：2015-04-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Seheon KIM ,  William DOS SANTOS FEGADOLLI ,  Axel SCHERER

IPC: H01S5/227 ,  H01S5/20 ,  H01S5/22 ,  H01S5/30 ,  H01S5/10

CPC classification number: H01S5/2275 ,  B82Y20/00 ,  H01S5/021 ,  H01S5/026 ,  H01S5/0425 ,  H01S5/1028 ,  H01S5/1042 ,  H01S5/105 ,  H01S5/2045 ,  H01S5/2228 ,  H01S5/3013 ,  H01S5/3213 ,  H01S5/34306 ,  H01S2304/00 ,  H01S2304/02

Abstract: Novel methods and systems for miniaturized lasers are described. A photonic crystal is bonded to a silicon-on-insulator wafer. The photonic crystal includes air-holes and can include a waveguide which couples the laser output to a silicon waveguide.

Abstract translation: 描述了用于小型化激光器的新颖方法和系统。 光子晶体结合到绝缘体上硅晶片上。 光子晶体包括气孔，并且可以包括将激光输出耦合到硅波导的波导。

公开(公告)号：US20140127796A1

公开(公告)日：2014-05-08

申请号：US14070440

申请日：2013-11-01

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Imran R. MALIK ,  Axel SCHERER ,  Erika F. GARCIA ,  Xiomara L. MADERO

IPC: C12M1/40

CPC classification number: C12M21/18 ,  B01L3/0275 ,  B01L3/502707 ,  B01L3/502715 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/022 ,  B01L2300/023 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/087 ,  B01L2300/1827 ,  B01L2400/0478

Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers.

Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有容器的线性或圆形布置，其具有连接结构，例如杆或盘。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 可以将不同的功能元件，例如研磨机或混合器附接到容器。

公开(公告)号：US20140087359A1

公开(公告)日：2014-03-27

申请号：US14033365

申请日：2013-09-20

Applicant: California Institute of Technology

Inventor： Samuel NJOROGE ,  John GORMAN ,  George MALTEZOS ,  Axel SCHERER

IPC: C12M1/00 ,  C12N1/06

CPC classification number: C12M47/06 ,  B01L3/5027 ,  B01L7/52 ,  B01L2300/1883 ,  C12M21/00 ,  C12N1/06 ,  C12N1/066 ,  G01N27/44791

Abstract: Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The methods and compositions may comprise a microfluidic chip or use thereof. The microfluidic chips disclosed herein may comprise (a) a substrate comprising a chamber, wherein at least one mechanical element may be located within the chamber; (b) a thermal element in contact with the chamber; and (c) at least one aperture within the surface of the substrate, wherein the aperture may be configured to insulate the chamber.

Abstract translation: 本文公开了用于制备样品的方法和系统。 方法和系统可用于裂解样品中的一种或多种结构（例如，细胞，病毒颗粒等）。 所述方法和组合物可以包含微流控芯片或其用途。 本文公开的微流体芯片可以包括（a）包括腔室的基底，其中至少一个机械元件可以位于腔室内; （b）与所述室接触的热元件; 以及（c）在所述基底表面内的至少一个孔，其中所述孔可以被配置为使所述腔绝缘。

公开(公告)号：US20140057278A1

公开(公告)日：2014-02-27

申请号：US14070465

申请日：2013-11-01

Applicant: California Institute Of Technology

Inventor： Xiomara Linnette MADERO ,  Imran R MALIK ,  Erika F GARCIA ,  Axel SCHERER

IPC: C12N15/10

CPC classification number: C12N15/1017 ,  F17D3/00 ,  G01N21/75 ,  Y10T137/8593

Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a circular arrangement of containers, with a connecting structure such as a disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. The device may be pen-shaped and have a sample drawing needle connected to the containers.

Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有圆形布置的容器，具有诸如盘的连接结构。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 该装置可以是笔形的并且具有连接到容器的抽样针。

公开(公告)号：US20140036267A1

公开(公告)日：2014-02-06

申请号：US13947469

申请日：2013-07-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Imran R. MALIK ,  Xiomara L. MADERO ,  Erika F. GARCIA ,  Axel SCHERER

IPC: G01N21/64

CPC classification number: G01N21/64 ,  G01N21/0303 ,  G01N21/645

Abstract: Structures and methods are described for optical detection of physical, chemical and/or biological samples. An optical detection structure may include a LED source, multiple filters and single or multiple sample areas. A detector may be used to record a fluorescence signal. The sample area may allow the introduction of removable cartridges.

Abstract translation: 描述了物理，化学和/或生物样品的光学检测的结构和方法。 光学检测结构可以包括LED源，多个滤光器和单个或多个样品区域。 检测器可用于记录荧光信号。 样品区域可能允许引入可移除的墨盒。

公开(公告)号：US20130210080A1

公开(公告)日：2013-08-15

申请号：US13763352

申请日：2013-02-08

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Aditya RAJAGOPAL ,  Samson CHEN ,  Axel SCHERER ,  Christopher I. WALKER

IPC: B01L7/00 ,  H05K3/46

CPC classification number: B01L7/52 ,  B01L3/502707 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686 ,  H05K1/0212 ,  H05K1/0272 ,  H05K1/028 ,  H05K3/46 ,  H05K3/4697 ,  Y10T29/49124

Abstract: An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB) fluidic device. The PCR chamber is a fluidic chamber and is located in, or is part of, the printed circuit board (PCB) fluidic device. A method for manufacturing an apparatus for performing the Polymerase Chain Reaction and a method for performing the Polymerase Chain Reaction are further disclosed.

Abstract translation: 公开了一种用于进行聚合酶链式反应（PCR）的装置。 该装置包括用于进行聚合酶链式反应的PCR室和印刷电路板（PCB）流体装置。 PCR室是流体室，并且位于印刷电路板（PCB）流体装置中或者是其中的一部分。 进一步公开了进行聚合酶链式反应的装置的制造方法和进行聚合酶链式反应的方法。

公开(公告)号：US20250084463A1

公开(公告)日：2025-03-13

申请号：US18893086

申请日：2024-09-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Emil P. KARTALOV ,  Aditya RAJAGOPAL ,  Axel SCHERER

IPC: C12Q1/6825 ,  C12Q1/68 ,  C12Q1/6851 ,  G01N21/64 ,  G06F17/10 ,  G06F17/11 ,  G16B5/00 ,  G16B25/00 ,  G16B25/20 ,  G16B40/00 ,  G16B40/10

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：US20240234206A1

公开(公告)日：2024-07-11

申请号：US18451808

申请日：2023-08-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER

IPC: H01L21/768 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/20 ,  H01L21/311 ,  H01L23/532

CPC classification number: H01L21/76879 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/2059 ,  H01L21/31144 ,  H01L23/5329

Abstract: Methods for utilizing irradiation to selectively transform insulating self-developing resists, such as metal fluorides, into electrically conductive metals are described. The disclosed methods enable the fabrication of electrical components and structures with critical dimensions below 5 nanometers. Selective irradiation induces the conversion of insulating metal fluoride compounds into metals in predefined regions. Examples of applications include miniature wiring, quantum point contacts, miniature electroplating and via-holes fabrication by using fluoride as etching mask.

公开(公告)号：US20240148248A1

公开(公告)日：2024-05-09

申请号：US18307361

申请日：2023-04-26

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel SCHERER ,  Peter A PETILLO ,  Samson CHEN ,  Azita EMAMI

IPC: A61B5/00 ,  A01K1/03 ,  A01K11/00 ,  A01K29/00 ,  A61B5/11 ,  H04B5/24

CPC classification number: A61B5/002 ,  A01K1/031 ,  A01K11/006 ,  A01K29/00 ,  A61B5/1113 ,  H04B5/24 ,  A61B5/01

Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.

公开(公告)号：US20240093273A1

公开(公告)日：2024-03-21

申请号：US18516842

申请日：2023-11-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Emil P. KARTALOV ,  Aditya RAJAGOPAL ,  Axel SCHERER

IPC: C12Q1/6825 ,  C12Q1/68 ,  C12Q1/6851 ,  G01N21/64 ,  G16B5/00 ,  G16B25/00 ,  G16B25/20 ,  G16B40/10

CPC classification number: C12Q1/6825 ,  C12Q1/68 ,  C12Q1/6851 ,  G01N21/6486 ,  G16B5/00 ,  G16B25/00 ,  G16B25/20 ,  G16B40/10 ,  G06F17/10

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.