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    KIDNEY DISEASE BIOMARKER
    31.
    发明申请
    KIDNEY DISEASE BIOMARKER 审中-公开
    KIDNEY疾病生物标志

    公开(公告)号：US20150219670A1

    公开(公告)日：2015-08-06

    申请号：US14421382

    申请日：2013-08-12

    Applicant: Randox Laboratories Ltd.

    Inventor： Ivan McConnell ,  Stephen Peter Fitzgerald ,  John Lamont ,  Claran Richardson

    IPC: G01N33/68 ,  G01N33/70 ,  G01N33/573

    CPC classification number: G01N33/6893 ,  C07K14/475 ,  C07K14/8139 ,  C12N9/104 ,  G01N33/573 ,  G01N33/6845 ,  G01N33/70 ,  G01N33/92 ,  G01N2333/47 ,  G01N2333/8139 ,  G01N2333/9108 ,  G01N2333/91188 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/56

    Abstract: The present invention provides a method of stratifying a patient suffering from CKD into one of stages 1-3 of CKD, comprising determining the level of the biomarkers FABP1, γ-GT, AST, creatinine and cystatin C in a sample obtained from the patient and comparing the level of FABP1 in the sample to a control value and the levels of γ-GT, AST, creatinine and cystatin C in the sample to a range of control values for each biomarker, wherein an increased level of FABP1 compared to the control value and levels of γ-GT, AST, creatinine and cystatin C within the range of control values for each biomarker indicate that the patient suffers from stage 1 CKD or wherein an increased level of FABP1 compared to the control value, levels of γ-GT and AST within the range of control values for each biomarker, and increased levels of creatinine and cystatin C compared to an upper threshold of the control range for these biomarkers indicate that the patient suffers from stage 2 or stage 3 CKD.

    Abstract translation: 本发明提供了将患有CKD的患者分为CKD的1-3期的方法，包括测定从患者获得的样品中生物标志物FABP1，γ-GT，AST，肌酐和半胱氨酸蛋白酶抑制剂C的水平，以及 将样品中FABP1的水平与对照值和样品中的γ-GT，AST，肌酐和半胱氨酸蛋白酶抑制剂C的水平进行比较，对每种生物标志物的对照值范围进行比较，其中FABP1水平与对照值相比增加 并且每个生物标志物的对照值范围内的γ-GT，AST，肌酐和半胱氨酸蛋白酶抑制剂C的水平表明患者患有1期CKD或其中FABP1水平与对照值相比增加，γ-GT水平和 在每个生物标志物的对照值范围内的AST和与这些生物标志物的对照范围的上限阈值相比，肌酐和半胱氨酸蛋白酶抑制剂C的水平升高表明患者患有2期或3期CKD。

    A HOLDER FOR PIPETTE TIPS
    34.
    发明申请
    A HOLDER FOR PIPETTE TIPS 有权

    公开(公告)号：US20220176380A1

    公开(公告)日：2022-06-09

    申请号：US17602863

    申请日：2020-04-08

    Applicant: RANDOX LABORATORIES LTD

    Inventor： Paul Courtney ,  Christine Maybin ,  Stuart Jackson

    IPC: B01L9/00

    Abstract: A holder for holding pipette tips of a molecular diagnostics assay analyser comprises a frame comprising a plurality of bores which are separated from each other, each bore configured to removably hold a first end of a pipette tip and a drip tray spaced apart from the plurality of bores, the drip tray configured to receive a second end of a pipette tip when said pipette tip is held by one of the plurality of bores, thereby allowing the pipette tip to be placed in the holder for re-use.

    Assay Cartridge and Support Housing
    35.
    发明申请
    Assay Cartridge and Support Housing 有权

    公开(公告)号：US20220143618A1

    公开(公告)日：2022-05-12

    申请号：US17602826

    申请日：2020-04-09

    Applicant: RANDOX LABORATORIES LTD

    Inventor： Marc Wharry ,  Martin Reid ,  Peter Fitzgerald

    IPC: B01L3/00 ,  B01L9/00

    Abstract: An assay cartridge (31) for use in a molecular diagnostics assay comprising: an assay region (32), possibly containing a plurality of reagent wells (34); a first end comprising a first engagement member (35), such as a lip or protrusion, for engaging with a support housing; and a second end comprising a second engagement member (36) for engaging with a support housing; wherein the second engagement member comprises a clip, the clip being formed by a resilient element extending from the second end of the cartridge and a fastening element extending from said resilient element; wherein the clip comprises a release element extending from the resilient element actuatable to release the clip from a caddy or support housing in use.

    Chemiluminescence detector
    36.
    发明授权
    Chemiluminescence detector 有权

    公开(公告)号：US11169093B2

    公开(公告)日：2021-11-09

    申请号：US16069492

    申请日：2017-01-13

    Applicant: Randox Laboratories Ltd.

    Inventor： Stuart Jackson ,  Ivan McConnell ,  Peter Fitzgerald

    IPC: G01N21/76 ,  G01N21/64

    Abstract: The present invention provides a chemiluminescence detector, which comprises an image capture device sensitive to chemiluminescence located within a container. The container has an array of apertures located in a field of view of the image capture device, and each aperture is defined by a through-bore in a wall of the container. The exterior of the container is engagable with a plurality of sample holders, each sample holder being in alignment with a respective aperture when engaged with the exterior of the container. The passage of light into the container through each aperture is restrictable by a closure device, passage of light into the container through the apertures is thereby controllable.

    Cartridge Sealing Apparatus
    37.
    发明申请
    Cartridge Sealing Apparatus 有权

    公开(公告)号：US20210284368A1

    公开(公告)日：2021-09-16

    申请号：US17255703

    申请日：2019-06-28

    Applicant: Randox Laboratories Ltd

    Inventor： James Moran ,  Mark Wilson

    IPC: B65B7/28 ,  B65B7/16 ,  B29C65/00

    Abstract: There is provided a cartridge sealing apparatus (1) comprising a sealing head (10) having a sealing surface (12), the sealing head being adapted in use to hold a sealing member (70) against a surface of a cartridge (100) by application of pressure to the sealing member at the sealing surface across a portion of the sealing member, a bonding layer being present between the sealing member and the cartridge thereby causing the sealing member (70) to seal the cartridge when held against the surface of the cartridge; and a cutting edge (20) arranged around the sealing head (10). The cutting edge is configured to move when the sealing member is held against the surface of the cartridge by the sealing head, from an unextended position, in which the cutting edge is located adjacent the sealing head, to an extended position, in which the cutting edge is adapted to cut the sealing member.

    BIOLOGICAL STATUS CLASSIFICATION
    38.
    发明申请
    BIOLOGICAL STATUS CLASSIFICATION 有权

    公开(公告)号：US20210033618A1

    公开(公告)日：2021-02-04

    申请号：US16943348

    申请日：2020-07-30

    Applicant: Randox Laboratories Ltd

    Inventor： Paul John Innocenzi ,  Stephen Peter Fitzgerald ,  Ivan Robert McConnell

    IPC: G01N33/68 ,  G16H50/30 ,  G16H10/40 ,  G16H70/60 ,  G16H20/60

    Abstract: There is provided a method of classifying a biological status of an individual. The method comprising: obtaining a biological sample from a patient; obtaining health-related information from the patient, said information including patient gender; analysing the sample to identify a quantity of each of 2 or more endogenous analytes in the sample; comparing the analyte quantities to reference data from healthy individuals to classify the patient as healthy, pre-diseased, at risk of disease or diseased for at least one health-related condition. The reference data includes data derived from a group of biological samples of individuals having the same gender as the patient and not having a need for medical treatment for a disease or illness, each biological sample of the group of biological samples having been analysed by the same process as used to analyse the patient sample, the process being monitored to maintain a predetermined level of consistency.

    Genetic factors in blood pressure
    39.
    发明授权
    Genetic factors in blood pressure 有权

    公开(公告)号：US10697017B2

    公开(公告)日：2020-06-30

    申请号：US14367510

    申请日：2012-12-21

    Applicant: RANDOX LABORATORIES LTD.

    Inventor： Sophie Visvikis-Siest ,  Said El Shamieh ,  Helena Murray ,  John Lamont ,  Peter Fitzgerald

    IPC: C12Q1/6883

    Abstract: The invention describes epistatic interactions between single nucleotide polymorphisms on genes associated with blood pressure and provides an application for their use in a method to determine an individual's susceptibility to hypertension and hence whether anti-hypertensive treatment will be beneficial for said individual. In addition gene expression levels are also linked to blood pressure and may also be used to determine susceptibility to hypertension.

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