公开(公告)号：US10697017B2

公开(公告)日：2020-06-30

申请号：US14367510

申请日：2012-12-21

Applicant: RANDOX LABORATORIES LTD.

Inventor： Sophie Visvikis-Siest ,  Said El Shamieh ,  Helena Murray ,  John Lamont ,  Peter Fitzgerald

IPC: C12Q1/6883

Abstract: The invention describes epistatic interactions between single nucleotide polymorphisms on genes associated with blood pressure and provides an application for their use in a method to determine an individual's susceptibility to hypertension and hence whether anti-hypertensive treatment will be beneficial for said individual. In addition gene expression levels are also linked to blood pressure and may also be used to determine susceptibility to hypertension.

公开(公告)号：US20140336283A1

公开(公告)日：2014-11-13

申请号：US14367510

申请日：2012-12-21

Applicant: RANDOX LABORATORIES LTD.

Inventor： Sophie Visvikis-Siest ,  Said El Shamieh ,  Helena Murray ,  John Lamont ,  Peter Fitzgerald

IPC: C12Q1/68

Abstract: The invention describes epistatic interactions between single nucleotide polymorphisms on genes associated with blood pressure and provides an application for their use in a method to determine an individual's susceptibility to hypertension and hence whether anti-hypertensive treatment will be beneficial for said individual. In addition gene expression levels are also linked to blood pressure and may also be used to determine susceptibility to hypertension.

Abstract translation: 本发明描述了与血压相关的基因的单核苷酸多态性之间的上位相互作用，并提供了其在确定个体对高血压易感性的方法中的应用，因此抗高血压治疗是否对所述个体有益。 此外，基因表达水平也与血压相关，也可用于确定对高血压的易感性。