公开(公告)号：US20020146847A1

公开(公告)日：2002-10-10

申请号：US10046728

申请日：2002-01-17

Applicant: RANDOX LABORATORIES LTD.

Inventor： John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald

IPC: C12Q001/68 ,  G01N033/543 ,  G06K009/00 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

CPC classification number: B82Y30/00 ,  B01J2219/00274 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00677 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B50/08 ,  G01N21/253

Abstract: A method for imaging molecules contained in an array of discrete reaction sites on the surface of a solid support comprises: (i) imaging the array and detecting a first molecule located on the solid support at a known position with respect to the array; (ii) by reference to the first molecule, aligning inspection windows in registration with the discrete reaction sites; and (iii) determining the amount of detectable signal in each window. The method is used to locate the reaction sites accurately on the array, and to correct for any misalignments.

Abstract translation: 用于对包含在固体支持物表面上的离散反应位点阵列中的分子进行成像的分子的方法包括：（i）对阵列进行成像并检测位于相对于阵列的已知位置的固体支持物上的第一分子; （ii）通过参考第一分子，将检查窗对准离散的反应位点; 和（iii）确定每个窗口中的可检测信号的量。 该方法用于在阵列上准确定位反应位点，并纠正任何错位。

公开(公告)号：US20040191890A1

公开(公告)日：2004-09-30

申请号：US10643926

申请日：2003-08-20

Applicant: RANDOX LABORATORIES LTD

Inventor： James Rudolf Meyer ,  Ahti Kalevi Kansanaho ,  Stephen Peter Fitzgerald ,  Robert Ivan McConnell ,  John Victor Lamont ,  Bailin Cao

IPC: C12M001/34

CPC classification number: G01N35/028 ,  G01N35/00029 ,  G01N35/0099 ,  G01N2035/00158 ,  G01N2035/00326 ,  G01N2035/0425 ,  Y10T436/113332

Abstract: An assay device processing instrument comprises a plurality of processing modules. A transport system transports an assay device to each processing module, the transport system being adapted to transfer the assay device from the transport system to the module to enable the transport system to transport another assay device while the first is processed by the processing module. A control system controls operation of the transport system such that each assay device is transferred between the modules in a predetermined sequence, and such that a number of assay devices can be processed in different modules simultaneously.

Abstract translation: 测定装置处理装置包括多个处理模块。 运输系统将测定装置运送到每个处理模块，所述运输系统适于将测定装置从运输系统传送到模块，以使得运输系统能够在第一个由处理模块处理的同时运送另一个测定装置。 控制系统控制运输系统的操作，使得每个测定装置以预定顺序在模块之间转移，并且使得可以同时在不同模块中处理多个测定装置。

公开(公告)号：US20030044833A1

公开(公告)日：2003-03-06

申请号：US10233419

申请日：2002-09-04

Applicant: Randox Laboratories Ltd.

Inventor： Elouard Benchikh ,  Robert Ivan McConnell ,  John Victor Lamont ,  Stephen Peter Fitzgerald

IPC: C12Q001/68 ,  B05D003/00 ,  G01N033/53 ,  G01N033/542 ,  C12M001/34

CPC classification number: G01N33/54353 ,  G01N33/54393 ,  G01N33/551

Abstract: Multi-analyte microarrays are produced by first attaching to the surface of a solid support, a silane with an electrophilic terminal group, contacting the terminal group with a polyamine, and activating the polyamine with an electrophilic, bifunctional linker.

Abstract translation: 多分析物微阵列通过首先附着到固体支持物的表面，具有亲电子端基的硅烷，与末端基团与多胺接触，并用亲电子双功能连接体活化多胺来制备。

公开(公告)号：US20020086337A1

公开(公告)日：2002-07-04

申请号：US09949756

申请日：2001-09-12

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Peter Fitzgerald ,  John Victor Lamont ,  Robert Ivan McConnell

IPC: G01N033/53 ,  G01N033/542 ,  G01N033/536

CPC classification number: G01N33/94 ,  G01N33/54306

Abstract: An assay for an analyte in a sample, wherein the sample is contacted with an array of ligands including a ligand specific for the analyte, additionally comprises including a scavenger material that binds the analyte and thereby reduces its available concentration.

Abstract translation: 样品中分析物的分析物，其中样品与包括对分析物特异性的配体的配体阵列接触，另外包括包含结合分析物的清除剂材料，从而降低其可用浓度。

公开(公告)号：US20020058319A1

公开(公告)日：2002-05-16

申请号：US09949757

申请日：2001-09-12

Applicant: RANDOX LABORATORIES LTD.

Inventor： Stephen Peter Fitzgerald ,  John Campbell ,  John Victor Lamont ,  Marlene King

IPC: C12N009/96 ,  A61K038/54

CPC classification number: C12N9/0065 ,  C12N9/0006 ,  C12N9/96

Abstract: A method for stabilizing an enzyme during freezing, wherein the enzyme is in a zwitterionic buffer solution. The zwitterionic buffer is able to maintain the activity of the enzyme during freezing and thawing.

Abstract translation: 一种用于在冷冻期间稳定酶的方法，其中所述酶在两性离子缓冲溶液中。 两性离子缓冲液能够在冷冻和解冻期间保持酶的活性。

公开(公告)号：US20030157565A1

公开(公告)日：2003-08-21

申请号：US10323850

申请日：2002-12-20

Applicant: RANDOX LABORATORIES LTD.

Inventor： John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald ,  El Ouard Benchikh ,  Andrew Philip Lowry

IPC: G01N033/53 ,  G01N033/537 ,  G01N033/543 ,  C07K016/46 ,  C07K014/00 ,  C07D489/02

CPC classification number: G01N33/9486 ,  C07D489/02

Abstract: Novel haptens, which can be conjugated to form immunogens, are of formula I, II or III 1 wherein R is a divalent alkyl, cycloalkyl or aryl group having 1 to 10 carbon atoms, and X is a functional group.

Abstract translation: 可以结合形成免疫原的新型半抗原具有式I，II或III，其中R是具有1至10个碳原子的二价烷基，环烷基或芳基，X是官能团。

公开(公告)号：US20030109051A1

公开(公告)日：2003-06-12

申请号：US10269884

申请日：2002-10-15

Applicant: RANDOX LABORATORIES LTD

Inventor： Stephen Peter Fitzgerald ,  Lynne Hamilton ,  Paul Graham Winyard

IPC: G01N033/50

CPC classification number: G01N33/84

Abstract: A spin-trapping assay for nitric oxide, in a biological system such as whole blood, uses as the spin trap a lipid-soluble nitrobenzene compound such as 2,6-dimethylnitrosobenzene.

Abstract translation: 在诸如全血的生物系统中，一氧化氮的自旋捕获测定法用作可溶性硝基苯化合物如2,6-二甲基亚硝基苯的自旋阱。

公开(公告)号：US20030008385A1

公开(公告)日：2003-01-09

申请号：US10188796

申请日：2002-07-05

Applicant: RANDOX LABORATORIES LTD

Inventor： Mark Tweedie ,  John Victor Lamont ,  Robert Ivan McConnell ,  Stephen Peter Fitzgerald

IPC: C12M001/34 ,  B05D003/00 ,  B41J029/38

CPC classification number: G01N35/00603 ,  B01J19/0046 ,  B01J2219/00351 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/0054 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01L3/0268 ,  B82Y30/00 ,  C40B60/14 ,  C40B70/00 ,  G01N35/10 ,  G01N2035/1034

Abstract: A biochip deposition system and method. The system comprises a deposit mechanism for depositing organic material in spots on a substrate; and a viewing system for detecting the spots on the substrate during a deposit operation and before the spots have dried, for determining if the spots have been correctly deposited, and if not, for generating a suitable output signal. The viewing system includes an illumination device for illuminating deposited spots at a relatively low angle relative to the substrate.

Abstract translation: 一种生物芯片沉积系统及方法。 该系统包括用于在基板上的点沉积有机材料的沉积机构; 以及观察系统，用于在沉积操作期间和斑点干燥之前检测基板上的斑点，以确定斑点是否已被正确沉积，如果不是，则用于产生合适的输出信号。 观察系统包括用于以相对于衬底相对低的角度照射沉积点的照明装置。