公开(公告)号：US5128475A

公开(公告)日：1992-07-07

申请号：US535691

申请日：1990-06-11

申请人： Eit Drent

发明人： Eit Drent

IPC分类号： B01J31/12 ,  B01J31/04 ,  C07B43/06 ,  C07B61/00 ,  C07C231/10 ,  C07C233/07 ,  C07C233/09 ,  C07C233/58 ,  C07C233/62 ,  C07C233/91 ,  C07C303/22 ,  C07C309/51 ,  C07D207/27 ,  C07F9/58

CPC分类号： C07F9/587 ,  C07C231/10 ,  C07C2102/42 ,  C07C2103/62

摘要： A process for the preparation of an amide, which comprises reacting an acetylenically or olefinically unsaturated compound with carbon monoxide and a nitrogen compound selected from ammonia and a primary or secondary amine or amide, in the presence of a catalyst system which comprises:a) a source of a Group VIII metal,b) a phosphine having an aromatic substituent which contains an imino nitrogen atom, andc) a protonic acid.

公开(公告)号：US4966914A

公开(公告)日：1990-10-30

申请号：US285007

申请日：1988-12-15

申请人： Ghanshyam Patil ,  William L. Matier ,  Khuong H. X. Mai

发明人： Ghanshyam Patil ,  William L. Matier ,  Khuong H. X. Mai

IPC分类号： A61K31/24 ,  A61K31/245 ,  A61K31/34 ,  A61K31/341 ,  A61K31/35 ,  A61K31/351 ,  A61K31/535 ,  A61K31/5375 ,  A61P25/02 ,  A61P27/02 ,  A61P27/06 ,  C07C233/36 ,  C07C233/37 ,  C07C233/40 ,  C07C233/62 ,  C07C233/78 ,  C07C235/50 ,  C07C235/60 ,  C07D295/18 ,  C07D295/215 ,  C07D307/24 ,  C07D307/68 ,  C07D309/08

CPC分类号： C07D295/215 ,  C07C233/36 ,  C07C233/37 ,  C07C233/40 ,  C07C233/62 ,  C07C233/78 ,  C07C235/50 ,  C07C235/60 ,  C07D307/24 ,  C07D307/68 ,  C07C2101/02 ,  C07C2101/04 ,  C07C2101/14

摘要： In accordance with the present invention, disclosed herein are compounds of the formula ##STR1## wherein R is hydrogen, straight or branched loweralkyl, cycloalkyl, amino, loweralkoxy or acylamino, and R.sub.1 is straight or branched loweralkyl, amino, cyclohexyl phenyl or phenyl substituted with loweralkyl, loweralkoxy or halo, benzyl, morpholino, piperidino, tetrahydrofuranyl, dihydrofuranyl, furanyl, tetrahydropyranyl, dioxolanyl, 2,2-dimethyl dioxolanyl, dioxanyl, pyrrolidinyl, tetrahydrooxazolyl, and dihydrooxazolyl, R.sub.2 is hydrogen or --COR.sub.3 wherein R.sub.3 is straight or branched loweralkyl, provided, however, when R.sub.1 is loweralkyl or cyclohexyl, R.sub.2 is not hydrogen, and pharmaceutically acceptable salts thereof. The compounds are useful in the treatment of glaucoma.

公开(公告)号：US4935422A

公开(公告)日：1990-06-19

申请号：US285008

申请日：1988-12-15

申请人： Ghanshyam Patil ,  Khuong H. X. Mai

发明人： Ghanshyam Patil ,  Khuong H. X. Mai

IPC分类号： A61K31/215 ,  A61K31/22 ,  A61K31/34 ,  A61K31/341 ,  A61K31/40 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61K31/54 ,  A61P5/38 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P25/02 ,  A61P27/02 ,  A61P27/06 ,  C07C219/02 ,  C07C219/06 ,  C07C219/12 ,  C07C233/18 ,  C07C233/36 ,  C07C233/62 ,  C07C233/78 ,  C07C275/14 ,  C07C275/26 ,  C07C275/28 ,  C07D211/60 ,  C07D233/88 ,  C07D295/10 ,  C07D295/20 ,  C07D295/215 ,  C07D307/24

CPC分类号： C07D295/215 ,  C07C219/06 ,  C07C219/12 ,  C07C233/18 ,  C07D307/24 ,  C07C2101/00

摘要： Compounds of the present invention, are represented by the general formula ##STR1## wherein R represents a straight or branched loweralkyl from 1 to about 6 carbon atoms, loweralkene from 2 to about 6 carbon atoms, or ##STR2## where m is o or 1 and n is 2, 3, 4, or 5 provided that when m is o, n is 2, 3, 4, or 5 and when m is 1, n is 3 or 4, and R.sub.1 is hydrogen, a straight, branched or cyclic loweralky from 1 to about 6 carbon atoms or loweralkoxy, phenyl or substituted phenyl, and R.sub.2 represents a straight or branched loweralkyl from 1 to about 6 carbon atoms or W-B wherein W represents alkylene of from 1 to about 10 carbon atoms which may be substituted with loweralkyl of from 1 to about 4 carbon atoms; and B represents hydrogen, --NHCOR.sub.4, or --NHCONR.sub.3 R.sub.4, wherein R.sub.3 and R.sub.4 may be the same or diffrent and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, phenyl or aralkyl wherein the alkyl group contains from 1 to about 6 carbon atoms and the aryl group represents phenyl which may be unsubstituted or substituted with lower alkyl from 1 to about 6 carbon atoms, alkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms, halogen, acetamido, amino, hydroxy, hydroxyalkyl of from 1 to about 10 carbon atoms; thiophenyl, imidazole, oxazole or indole, furanyl, tetrahydrofuranyl or R.sub.3 and R.sub.4 may together with N form a pyrrolidino, piperidino, piperazino, or morpholino ring, or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment or prophylaxis of cardiac disorder or in the treatment of glaucoma.

公开(公告)号：US4888355A

公开(公告)日：1989-12-19

申请号：US136814

申请日：1987-12-22

申请人： Francois Clemence ,  Odile Le Martret ,  Michel Fortin ,  Francoise Delevallee

发明人： Francois Clemence ,  Odile Le Martret ,  Michel Fortin ,  Francoise Delevallee

IPC分类号： C07D209/42 ,  A61K31/165 ,  A61K31/33 ,  A61K31/34 ,  A61K31/343 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/42 ,  A61K31/423 ,  A61K31/425 ,  A61K31/428 ,  A61K31/47 ,  A61P3/04 ,  A61P7/10 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/04 ,  A61P25/06 ,  C07C67/00 ,  C07C209/00 ,  C07C209/16 ,  C07C209/60 ,  C07C209/62 ,  C07C211/42 ,  C07C213/00 ,  C07C215/44 ,  C07C217/74 ,  C07C231/00 ,  C07C231/02 ,  C07C233/11 ,  C07C233/23 ,  C07C233/41 ,  C07C233/62 ,  C07C233/65 ,  C07C233/74 ,  C07C233/79 ,  C07D215/14 ,  C07D215/48 ,  C07D235/04 ,  C07D263/54 ,  C07D277/64 ,  C07D295/12 ,  C07D295/135 ,  C07D295/155 ,  C07D307/79 ,  C07D333/24 ,  C07D333/54 ,  C07D403/12

CPC分类号： C07D295/135 ,  C07D295/155 ,  C07D333/24 ,  C07D333/54

摘要： A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms possible of compounds of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, and alkyl and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, one of A and B being ##STR2## and the other being ##STR3## R is hydrogen or alkyl of 1 to 5 carbon atoms, Z is --(CH.sub.2).sub.n -- or branched alkylene of 2 to 8 carbon atoms, n is an integer from 0 to 5, Y is selected from the group consisting of naphthyl, indenyl, heterobicyclics and heteromonocyclic containing 5 to 6 ring members, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, halogen, --OH, --CF.sub.3, --NO.sub.2, --NH.sub.2, monoalkylamino and dialkylamino of 1 to 4 alkyl carbon atoms and phenyl optionally substituted with at least one member of the group consisting of halogen and alkyl and alkoxy of 1 to 4 carbon atoms, R.sub.3 and R.sub.4 are individually hydrogen or alkyl of 1 to 5 carbon atoms or taken together with the nitrogen form a heterocyclic of 5 to 6 ring members and optionally containing --O--, --S-- or nitrogen in the ring and their non-toxic, pharmaceutically acceptable acid addition salts having central analgesic and antiarythmic activity among other activities.

摘要翻译： 选自下列化合物的化合物的化合物：其中X选自氢，卤素和1至5个碳原子的烷基和烷氧基，R 1和R 2的所有对映异构体和非对映异构体形式 分别选自氢和1至5个碳原子的烷基，A和B之一为“IMAGE”，另一个为R 1为氢或1至5个碳原子的烷基，Z为 - （ CH 2）2至8个碳原子的正或支链亚烷基，n为0至5的整数，Y选自萘基，茚基，异双环烯烃和含有5至6个环成员的杂单环，全部任选被 由1至5个碳原子的烷基和烷氧基，卤素，-OH，-CF 3，-NO 2，-NH 2，1至4个烷基碳原子的一烷基氨基和二烷基氨基组成的组中的至少一个和任选被至少一个 由卤素和卤素组成的组的成员 具有1至4个碳原子的烷基和烷氧基，R 3和R 4分别是氢或1至5个碳原子的烷基或与氮一起形成5至6个环成员的杂环，并任选地含有-O - ， - S-或 环中的氮和它们的无毒的药学上可接受的酸加成盐，具有其他活性的中枢镇痛和抗血液活性。

公开(公告)号：US4322551A

公开(公告)日：1982-03-30

申请号：US878199

申请日：1978-02-16

申请人： Niranjan V. Shah

发明人： Niranjan V. Shah

IPC分类号： C09K15/22 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C233/00 ,  C07C233/12 ,  C07C233/34 ,  C07C233/62 ,  C07C233/78 ,  C07C233/79 ,  C07C233/80 ,  C07C102/06

CPC分类号： C07C233/12 ,  C07C233/00 ,  C07C233/34

摘要： A process for the preparation of aromatic amide antioxidants from a simple aliphatic or aromatic ester and primary amine in the presence of a metal alkoxide and an alcohol. Unsaturated products produced using this process are sufficiently pure to use as comonomers in the preparation of elastomers.

摘要翻译： 一种在金属醇盐和醇存在下由简单脂族或芳族酯和伯胺制备芳族酰胺抗氧化剂的方法。 使用该方法生产的不饱和产物足够纯，可用作制备弹性体的共聚单体。

公开(公告)号：US20240226026A1

公开(公告)日：2024-07-11

申请号：US18551704

申请日：2022-03-23

申请人： ModernaTX, Inc.

发明人： Kerry E. BENENATO ,  Mark CORNEBISE ,  Edward HENNESSY ,  Mohindra SEEPERSAUD ,  Michael W. DANNEMAN

IPC分类号： A61K9/51 ,  C07C233/36 ,  C07C233/62 ,  C07C233/78 ,  C07C311/32 ,  C07D205/04 ,  C07D207/16 ,  C07D213/74 ,  C07D231/12 ,  C07D271/07 ,  C07D285/10 ,  C07D307/24 ,  C07D309/08

CPC分类号： A61K9/5123 ,  C07C233/36 ,  C07C233/62 ,  C07C233/78 ,  C07C311/32 ,  C07D205/04 ,  C07D207/16 ,  C07D213/74 ,  C07D231/12 ,  C07D271/07 ,  C07D285/10 ,  C07D307/24 ,  C07D309/08

摘要： The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：USRE49811E1

公开(公告)日：2024-01-23

申请号：US17688814

申请日：2022-03-07

申请人： Apogee Biotechnology Corporation

发明人： Charles D. Smith ,  Kevin J. French ,  Yan Zhuang

IPC分类号： C07C61/39 ,  C07C49/323 ,  C07C49/563 ,  C07C49/567 ,  C07C49/573 ,  C07C61/40 ,  C07C69/738 ,  C07C211/27 ,  C07C211/29 ,  C07C211/48 ,  C07C211/52 ,  C07C215/76 ,  C07C217/58 ,  C07C217/60 ,  C07C233/49 ,  C07C233/59 ,  C07C233/60 ,  C07C233/62 ,  C07C255/44 ,  C07C255/56 ,  C07C275/30 ,  C07C317/32 ,  C07C323/40 ,  C07D207/09 ,  C07D207/27 ,  C07D209/08 ,  C07D209/86 ,  C07D209/88 ,  C07D211/58 ,  C07D213/38 ,  C07D213/40 ,  C07D213/89 ,  C07D233/24 ,  C07D233/64 ,  C07D257/04 ,  C07D263/58 ,  C07D277/42 ,  C07D277/46 ,  C07D277/82 ,  C07D295/027 ,  C07D295/13 ,  C07D295/30 ,  C07D317/58 ,  C07D333/20 ,  C07D333/22 ,  C07D333/28 ,  C07D487/04

CPC分类号： C07C61/39 ,  C07C49/323 ,  C07C49/563 ,  C07C49/567 ,  C07C49/573 ,  C07C61/40 ,  C07C69/738 ,  C07C211/27 ,  C07C211/29 ,  C07C211/48 ,  C07C211/52 ,  C07C215/76 ,  C07C217/58 ,  C07C217/60 ,  C07C233/49 ,  C07C233/59 ,  C07C233/60 ,  C07C233/62 ,  C07C255/44 ,  C07C255/56 ,  C07C275/30 ,  C07C317/32 ,  C07C323/40 ,  C07D207/09 ,  C07D207/27 ,  C07D209/08 ,  C07D209/86 ,  C07D209/88 ,  C07D211/58 ,  C07D213/38 ,  C07D213/40 ,  C07D213/89 ,  C07D233/24 ,  C07D233/64 ,  C07D257/04 ,  C07D263/58 ,  C07D277/42 ,  C07D277/46 ,  C07D277/82 ,  C07D295/027 ,  C07D295/13 ,  C07D295/30 ,  C07D317/58 ,  C07D333/20 ,  C07D333/22 ,  C07D333/28 ,  C07D487/04 ,  C07C2601/02 ,  C07C2603/74

摘要： The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.

公开(公告)号：US11352316B2

公开(公告)日：2022-06-07

申请号：US16926536

申请日：2020-07-10

申请人： Epiodyne, Inc.

发明人： Julio Cesar Medina ,  Lawrence R McGee ,  Zhi-Liang Wei ,  Corinne Sadlowski ,  Frederick Seidl ,  Ulhas Bhatt ,  Xiaodong Wang ,  Thomas Nguyen ,  David Sperandio ,  Pingyu Ding ,  Alok Nerurkar ,  Yihong Li ,  Jason Duquette

IPC分类号： C07C233/78 ,  A61P23/00 ,  C07C233/62 ,  C07C233/63 ,  C07C235/60 ,  C07C237/42 ,  C07D207/16 ,  C07D209/14 ,  C07D217/06 ,  C07D217/14 ,  C07D231/56 ,  C07D241/24 ,  C07D263/58 ,  C07D295/13 ,  C07D403/06 ,  C07D471/04 ,  C07C237/30 ,  C07C237/38 ,  C07C237/48 ,  C07C271/20 ,  C07C275/24 ,  C07D209/34 ,  C07D213/40 ,  C07D401/12

摘要： Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R3, R4, R5, R6, R8, m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.

公开(公告)号：US20220169602A1

公开(公告)日：2022-06-02

申请号：US17437447

申请日：2020-03-20

申请人： Saniona A/S

发明人： David Tristram BROWN ,  Palle CHRISTOPHERSEN ,  Thomas Amos JACOBSEN ,  Janus S. LARSEN ,  Pernille Hartveit Poulsen ,  Dorte STRØBAEK

IPC分类号： C07D205/04 ,  C07D207/09 ,  C07D213/61 ,  C07D265/30 ,  C07C311/07 ,  C07C271/24 ,  C07C233/62 ,  C07C211/40

摘要： The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.

公开(公告)号：US20210400977A1

公开(公告)日：2021-12-30

申请号：US17296742

申请日：2019-11-15

申请人： FMC Corporation

发明人： Thomas Francis PAHUTSKI Jr. ,  Rachel SLACK ,  Andrew Jon DEANGELIS

IPC分类号： A01N53/00 ,  C07C233/62 ,  A01N25/02 ,  A01P15/00

摘要： Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Q, X, Y, A1, A2, L, R1, R2, R3, R4, R5, R6a, R6b, R7 and R8 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.