公开(公告)号：US20190314292A1

公开(公告)日：2019-10-17

申请号：US16382423

申请日：2019-04-12

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Ellalahewage Sathyajith KUMARASINGHE ,  Mark CORNEBISE

IPC: A61K9/51 ,  C07C229/24 ,  A61K48/00 ,  A61K38/18

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20190016669A1

公开(公告)日：2019-01-17

申请号：US16148822

申请日：2018-10-01

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark CORNEBISE

IPC: C07C229/12 ,  C07C227/16 ,  C07C271/20 ,  A61K9/00 ,  A61K9/127 ,  C07C227/18 ,  A61K48/00 ,  A61K38/17 ,  A61K31/7105 ,  A61K9/51 ,  A61K9/16 ,  A61K47/69 ,  A61K47/54 ,  C07K14/505 ,  A61K38/18 ,  C07F9/09 ,  C07C255/24 ,  C07C235/10 ,  C07C233/36 ,  C07C335/08 ,  C07C229/16 ,  C07C311/05 ,  C07C279/24 ,  C07C275/14 ,  C07D277/38 ,  C07D207/27 ,  C07D271/10 ,  C07D271/06 ,  C07D265/33 ,  C07D263/20 ,  C07D249/04 ,  C07D233/72 ,  C07C279/32 ,  C07C279/28 ,  C07C279/12

CPC classification number: C07C229/12 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/5123 ,  A61K9/5146 ,  A61K31/7105 ,  A61K38/1725 ,  A61K38/1816 ,  A61K47/543 ,  A61K47/6911 ,  A61K48/00 ,  A61K48/0033 ,  A61K48/005 ,  C07C227/16 ,  C07C227/18 ,  C07C229/16 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07C271/20 ,  C07C275/14 ,  C07C279/12 ,  C07C279/24 ,  C07C279/28 ,  C07C279/32 ,  C07C311/05 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/18 ,  C07D207/27 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D277/38 ,  C07F9/091 ,  C07K14/505

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20180201572A1

公开(公告)日：2018-07-19

申请号：US15846084

申请日：2017-12-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO

IPC: C07C229/12 ,  A61K9/00 ,  C07K14/505 ,  C07F9/09 ,  C07D277/38 ,  C07D271/10 ,  C07D271/06 ,  C07D265/33 ,  C07D263/20 ,  C07D249/04 ,  C07D233/72 ,  C07D207/27 ,  C07C335/08 ,  C07C311/05 ,  C07C279/32 ,  C07C279/28 ,  C07C279/24 ,  C07C279/12 ,  C07C275/14 ,  C07C271/20 ,  C07C255/24 ,  C07C235/10 ,  C07C233/36 ,  C07C229/16 ,  A61K48/00 ,  A61K47/69 ,  A61K47/54 ,  A61K38/18 ,  A61K9/16 ,  A61K9/127

CPC classification number: C07C229/12 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/5123 ,  A61K9/5146 ,  A61K31/7105 ,  A61K38/1725 ,  A61K38/1816 ,  A61K47/543 ,  A61K47/6911 ,  A61K48/00 ,  A61K48/0033 ,  A61K48/005 ,  C07C227/16 ,  C07C227/18 ,  C07C229/16 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07C271/20 ,  C07C275/14 ,  C07C279/12 ,  C07C279/24 ,  C07C279/28 ,  C07C279/32 ,  C07C311/05 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/18 ,  C07D207/27 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D277/38 ,  C07F9/091 ,  C07K14/505

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20230286903A1

公开(公告)日：2023-09-14

申请号：US18164136

申请日：2023-02-03

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark Cornebise ,  Edward Hennessy ,  Ellalahewage S. Kumarasinghe

IPC: C07C229/24 ,  A61K47/54 ,  A61K9/127 ,  A61K31/713 ,  A61K48/00

CPC classification number: C07C229/24 ,  A61K47/543 ,  A61K9/1272 ,  A61K31/713 ,  A61K48/0033 ,  A61K48/005

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20220380299A1

公开(公告)日：2022-12-01

申请号：US17538217

申请日：2021-11-30

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark CORNEBISE

IPC: C07C229/12 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K47/54 ,  A61K47/69 ,  A61K9/00 ,  A61K9/127 ,  C07C233/72 ,  C07C263/20 ,  A61K9/16 ,  A61K38/18 ,  A61K48/00 ,  C07K14/505 ,  C07C227/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  C07C227/18

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20210198200A1

公开(公告)日：2021-07-01

申请号：US16620666

申请日：2018-06-14

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  William BUTCHER

IPC: C07D211/28 ,  C07D207/09 ,  A61K9/51 ,  A61K47/60

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20230000773A1

公开(公告)日：2023-01-05

申请号：US17761863

申请日：2020-09-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark CORNEBISE ,  Edward HENNESSY ,  Andrew MCKENZIE

IPC: A61K9/127 ,  C07D285/10 ,  C07D207/456 ,  C07D237/22 ,  C07D233/88 ,  C07D249/14 ,  C07D271/08 ,  C07D239/22 ,  C07D241/20 ,  C07C237/10 ,  C07D209/14 ,  C07D231/56 ,  C07C311/05 ,  C07F5/02 ,  C07F9/36 ,  C07D319/12 ,  C07D307/68 ,  C07D239/38 ,  C07D285/18 ,  A61K31/7105

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20210161829A1

公开(公告)日：2021-06-03

申请号：US16991196

申请日：2020-08-12

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  William BUTCHER

IPC: A61K9/51 ,  C07D295/185 ,  C07D211/16 ,  C07D295/13 ,  C07D211/14 ,  A61K38/18 ,  A61K47/22 ,  A61K48/00 ,  C07D241/04

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20210087135A1

公开(公告)日：2021-03-25

申请号：US17025779

申请日：2020-09-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark CORNEBISE ,  Edward HENNESSY ,  Ellalahewage S. KUMARASINGHE

IPC: C07C229/24 ,  A61K48/00 ,  A61K9/127 ,  A61K47/54 ,  A61K31/713

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20180369419A1

公开(公告)日：2018-12-27

申请号：US16065067

申请日：2016-12-22

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  William BUTCHER

IPC: A61K48/00 ,  A61K47/22 ,  C07D241/04

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.