公开(公告)号：US20180008981A1

公开(公告)日：2018-01-11

申请号：US15545496

申请日：2016-01-22

申请人： ARKRAY, Inc. ,  NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY

发明人： Akira Murakami ,  Akio Kobori ,  Asako Yamayoshi ,  Yuichiro Noda ,  Masayuki Kondo

IPC分类号： B01L3/00 ,  B01L7/00 ,  G01N21/07 ,  G01N35/00

CPC分类号： B01L3/502753 ,  B01L7/52 ,  C12M1/00 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/07 ,  G01N21/64 ,  G01N33/53 ,  G01N33/536 ,  G01N35/00 ,  G01N35/00069 ,  G01N35/08 ,  G01N37/00

摘要： The present invention provides a novel target analysis chip and analysis method for directly detecting a target such as a microRNA without performing PCR.

公开(公告)号：US20170335408A1

公开(公告)日：2017-11-23

申请号：US15459666

申请日：2017-03-15

申请人： Abbott Laboratories

发明人： Frank Pawlowski ,  Joseph P. Skinner ,  Jack Kessler ,  Sonal Sadaria Nana

IPC分类号： C12Q1/68 ,  B01L9/00 ,  G01N30/88 ,  G01N35/00 ,  G01N33/569

CPC分类号： C12Q1/6888 ,  B01L9/523 ,  C12Q1/6806 ,  G01N30/88 ,  G01N33/48 ,  G01N33/56983 ,  G01N35/00 ,  G01N35/00584 ,  G01N2035/00326 ,  C12Q2527/113 ,  C12Q2531/113 ,  C12Q2545/114 ,  C12Q2561/113

摘要： The instant disclosure provides methods of multi-assay processing and multi-assay analysis. Such multi-assay processing and analysis pertain to automated detection of target nucleic acids, e.g., as performed in the clinical setting for diagnostic purposes. Also provided are common assay timing protocols derived from a variety of individual nucleic acid amplification and analysis protocols and modified to prevent resource contention. The instant disclosure also provides systems and devices for practicing the methods as described herein.

公开(公告)号：US09810651B2

公开(公告)日：2017-11-07

申请号：US14962223

申请日：2015-12-08

申请人： Roche Diagnostics Operations, Inc.

发明人： Markus Hegel

IPC分类号： G01N27/04 ,  G01N35/00 ,  B01L3/00 ,  G01N35/04 ,  B65B7/28

CPC分类号： G01N27/041 ,  B01L3/50825 ,  B01L2300/046 ,  B65B7/2807 ,  G01N35/00 ,  G01N35/04 ,  G01N2035/0403

摘要： A method and a device for handling a closing element in a laboratory automation system are presented. The closing element is a sealing foil having at least two layers forming a first surface and an opposing second surface, respectively. The layers differ in at least one material property. The material property on at least one of the first surface and the second surface for identifying the orientation of the sealing foil is determined. A laboratory automation system for carrying out the method and/or with the device is also presented.

公开(公告)号：US20170312746A1

公开(公告)日：2017-11-02

申请号：US15430197

申请日：2017-02-10

申请人： Theranos, Inc.

发明人： Elizabeth A. Holmes ,  Joy Roy ,  John Kent Frankovich

IPC分类号： B01L3/00 ,  G01N35/10 ,  B01L3/02 ,  B01L7/00 ,  B01L9/06

CPC分类号： B01L3/50825 ,  B01L3/0217 ,  B01L3/5021 ,  B01L3/523 ,  B01L7/52 ,  B01L9/06 ,  B01L2200/028 ,  B01L2200/0631 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/082 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0829 ,  B01L2400/0409 ,  B01L2400/043 ,  B01L2400/0677 ,  G01N35/00 ,  G01N35/1072 ,  G01N2035/00277 ,  Y10T436/25

摘要： Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20170292967A1

公开(公告)日：2017-10-12

申请号：US15482467

申请日：2017-04-07

申请人： I-SENS, INC.

发明人： Kyungho KIM ,  Jae Phil DO ,  Jaewon JUNG ,  Jung Uk HA ,  Sang Taek SHIN ,  Seok-Won LEE ,  Yungjoon JIN ,  Yusung KIM

IPC分类号： G01N35/02 ,  G01N35/00 ,  B04B15/02 ,  G01N35/04 ,  B04B5/04 ,  B04B7/02

CPC分类号： G01N35/025 ,  B01L3/5021 ,  B04B5/0407 ,  B04B7/02 ,  B04B15/02 ,  G01N21/07 ,  G01N21/76 ,  G01N33/491 ,  G01N35/00 ,  G01N35/00623 ,  G01N35/04 ,  G01N2035/00306 ,  G01N2035/00376 ,  G01N2035/00495 ,  G01N2035/00504 ,  G01N2035/0439 ,  G01N2035/0449

摘要： A modular automatic analyzer using a circular type cartridge enabling centrifugation according to an exemplary embodiment of the present invention includes: a main body frame; an X-axis conveying unit which reciprocally moves in an X-axis direction with respect to the main body frame; a circular type cartridge accommodating housing which is installed with respect to the X-axis conveying unit so as to be reciprocally movable in the X-axis direction by the X-axis conveying unit, a single rotation drive unit which is installed in the circular type cartridge accommodating housing and is rotated step by step at a predetermined interval or rotated at a high speed for centrifugation, a circular type cartridge which is installed at an upper surface of the circular type cartridge accommodating housing so as to be rotatably connected to the rotation drive unit and has wells disposed to be spaced apart from each other at predetermined intervals in a circumferential direction of a disc-shaped main body, a tip lifting unit which picks up and moves a tip upward and downward, a measurement unit which measures a reaction in the well, a Z-axis drive unit which is provided with the tip lifting unit and the measurement unit and reciprocally operates in a Z-axis direction with respect to the main body frame, and a control unit C which controls an automatic immunity analyzer.

公开(公告)号：US20170283845A1

公开(公告)日：2017-10-05

申请号：US15461081

申请日：2017-03-16

申请人： Theranos, Inc.

发明人： Elizabeth A. Holmes ,  Sunny Balwani

IPC分类号： C12Q1/00 ,  G01N33/48 ,  C12Q1/68 ,  G01N30/02 ,  C12Q1/02 ,  C12Q1/28

CPC分类号： G01N35/02 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/28 ,  C12Q1/68 ,  G01N30/02 ,  G01N33/48 ,  G01N33/559 ,  G01N33/566 ,  G01N33/86 ,  G01N35/00 ,  G01N35/0092 ,  G01N2035/00326 ,  G01N2035/00495

摘要： Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20170219559A1

公开(公告)日：2017-08-03

申请号：US15500890

申请日：2015-08-04

申请人： SCREENCELL

发明人： DAVID ZNATY ,  FRANÇOIS FORESTIER ,  GEORGES UZAN ,  CÉCILE AUCANT

IPC分类号： G01N33/49 ,  G01N1/40

CPC分类号： G01N33/49 ,  G01N1/4077 ,  G01N33/491 ,  G01N33/6893 ,  G01N33/80 ,  G01N35/00 ,  G01N2001/4088 ,  G01N2800/224

摘要： A method for detecting sickle-cell disease in an individual. A blood sample from an individual is brought into contact with an agent for inducing the sickling of red blood cells suitable for placing the red blood cells in a hypoxic condition. The blood sample is filtered through a porous membrane of which the pore size is determined to retain the sickled red blood cells, and allow the non-sickled red blood cells to pass through. The possible presence of a residue on the membrane is detected, during and/or after the filtering step. The presence indicating that the individual is suffering from sickle-cell disease.

公开(公告)号：US09695457B2

公开(公告)日：2017-07-04

申请号：US13147951

申请日：2010-02-05

申请人： Pranav Somaiya

发明人： Pranav Somaiya

IPC分类号： C12Q1/04 ,  C12M1/34 ,  C12N1/20 ,  C12Q1/14

CPC分类号： C12Q1/14 ,  C12Q1/04 ,  C12Q1/24 ,  G01N35/00 ,  G01N2035/00356 ,  G01N2035/00495 ,  G01N2333/31 ,  G01N2560/00 ,  G01N2570/00 ,  H01J49/0418

摘要： Methods for the detection or diagnosis of a bacterial infection or colonization utilizing mass spectrometric analysis are provided. The methods involve short-term enrichment of samples followed by mass spectrometric analysis of biomarker profiles. Also provided are methods for preparing short-term enrichment cultures.

公开(公告)号：US09632102B2

公开(公告)日：2017-04-25

申请号：US13244949

申请日：2011-09-26

申请人： Elizabeth Holmes ,  Sunny Balwani

发明人： Elizabeth Holmes ,  Sunny Balwani

IPC分类号： C12Q1/68 ,  G01N33/48 ,  G01N35/02 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/28 ,  G01N30/02 ,  G01N33/559 ,  G01N33/566 ,  G01N33/86 ,  G01N35/00

CPC分类号： G01N35/02 ,  C12Q1/00 ,  C12Q1/02 ,  C12Q1/28 ,  C12Q1/68 ,  G01N30/02 ,  G01N33/48 ,  G01N33/559 ,  G01N33/566 ,  G01N33/86 ,  G01N35/00 ,  G01N35/0092 ,  G01N2035/00326 ,  G01N2035/00495

摘要： Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20170097344A1

公开(公告)日：2017-04-06

申请号：US15127892

申请日：2015-03-20

申请人： Demetrios Samuel Maxim

发明人： Demetrios Samuel Maxim

IPC分类号： G01N33/543 ,  G01N21/31 ,  G01N1/28 ,  G01N21/27

CPC分类号： G01N33/54386 ,  G01N1/286 ,  G01N15/0612 ,  G01N21/253 ,  G01N21/272 ,  G01N21/3103 ,  G01N33/48707 ,  G01N35/00 ,  G01N35/028 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2800/245 ,  G01N2800/347 ,  G01N2800/7028

摘要： A portable assay instrument for rapid detection and quantification of biomarkers is described. The instrument may include components to automate steps of an assay. Assay-specific agitation during an incubation phase in which capture binding agents, detection binding agents, and conjugates are present in sample wells can appreciably increase the speed of the assay and improve assay sensitivity. The instrument may further include an optical detector and processor for automated probing of the sample wells and computation of biomarker concentration.