公开(公告)号：US20240316248A1

公开(公告)日：2024-09-26

申请号：US18268427

申请日：2020-12-22

申请人： MOCHIDA PHARMACEUTICAL CO., LTD. ,  NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE

发明人： Masayuki SHIMODA ,  Kumiko AJIMA ,  Shoji FURUSAKO ,  Naoto TSUDA

IPC分类号： A61L27/52 ,  A61L27/20 ,  A61L27/38 ,  A61L27/54 ,  C08L5/04

CPC分类号： A61L27/52 ,  A61L27/20 ,  A61L27/3804 ,  A61L27/54 ,  C08L5/04

摘要： Provided is a transplantation device comprising a hydrogel in which insulin-secreting cells or pancreatic islets are enclosed, wherein the hydrogel is prepared by gelatinizing an alginic acid derivative by a chemical crosslinking. Accordingly, a novel transplantation device is provided.

公开(公告)号：US20240307592A1

公开(公告)日：2024-09-19

申请号：US18034455

申请日：2021-10-29

申请人： Spiderwort Inc.

发明人： Ryan Hickey ,  Kama Szereszewski ,  Andrew E. Pelling ,  Paula Cristina de Sousa Faria Tischer ,  Anna CANTO ,  Joshua SALAMUN ,  Matthew LOURENCO

IPC分类号： A61L27/52 ,  A23L29/262 ,  A23L31/00 ,  A23P30/40 ,  A61L27/20 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  C08L5/14

CPC分类号： A61L27/52 ,  A23L29/262 ,  A23L31/00 ,  A23P30/40 ,  A61L27/20 ,  A61L27/383 ,  A61L27/54 ,  A61L27/56 ,  C08L5/14 ,  A61L2300/402 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/34 ,  A61L2430/38

摘要： Provided herein are aerogels and foams including: single structural cells and/or groups of structural cells derived from a plant or fungal tissue, the single structural cells having a decellularized 3D structure lacking cellular materials and nucleic acids of plant or fungal tissue; the single structural cells and/or groups of structural cells being distributed within a carrier derived from a dehydrated, lyophilized, or freeze-dried hydrogel. Also provided herein are methods for preparing aerogels or foams, including steps of: providing a decellularized plant or fungal tissue; obtaining single structural cells and/or groups of structural cells from the decellularized plant or fungal tissue by performing mercerization; mixing or distributing the single structural cells and/or groups of structural cells in a hydrogel, to provide a mixture; and dehydrating, lyophilizing, or freeze-drying the mixture to provide the aerogel or foam. Related methods and uses are also provided.

公开(公告)号：US20240299628A1

公开(公告)日：2024-09-12

申请号：US18664253

申请日：2024-05-14

申请人： TELA Bio, Inc.

发明人： E. Skott GREENHALGH

IPC分类号： A61L27/52 ,  A61L27/24 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61L27/52 ,  A61L27/24 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/626 ,  A61L2430/34

摘要： The apparatuses and methods described herein relates generally to the field of active agent (drug) release from surgical grafts useful for soft tissue reconstruction, regeneration, or repair. More particularly, described herein are surgical grafts for soft tissue repair that include an active agent that is released over time while advantageously matching the biomechanical properties of tissue during healing and recovery.

公开(公告)号：US12076464B2

公开(公告)日：2024-09-03

申请号：US17072166

申请日：2020-10-16

申请人： The Texas A&M University System

发明人： Duncan Maitland ,  Corey Bishop ,  Shreedevi Arun Kumar

IPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/54 ,  C08G18/32 ,  C08G18/34 ,  C08G18/38 ,  C08G18/73 ,  C08G101/00

CPC分类号： A61L27/56 ,  A61L27/18 ,  A61L27/54 ,  C08G18/3206 ,  C08G18/341 ,  C08G18/3825 ,  C08G18/73 ,  A61L2300/626 ,  A61L2300/802 ,  A61L2400/16 ,  C08G2101/00 ,  C08G2280/00

摘要： Tumor resection is commonly practiced to prevent the progression of cancer. However, there are post-surgery concerns including the formation of a void that can allow cancer cells to escape at the surgery site, which increases the risk of metastasis. To counter this challenge, an embodiment includes a polyurethane-based shape memory foam as a tissue void-filling device that can also release anti-cancer drugs. Such foams may activate at body temperature and become malleable. Such properties may enable the foam to be shaped to precisely seal the tissue void and then serve as a drug-eluting device. Based on the drug composition with poly vinyl alcohol (PVA), the drug release profile from the foam may be altered depending on the application.

公开(公告)号：US20240277846A1

公开(公告)日：2024-08-22

申请号：US18409423

申请日：2024-01-10

申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

发明人： Heemin KANG ,  Woo-Young JANG

IPC分类号： A61K41/00 ,  A61K33/26 ,  A61K47/54 ,  A61L27/04 ,  A61L27/12 ,  A61L27/54 ,  A61P19/00

CPC分类号： A61K41/00 ,  A61K33/26 ,  A61K47/549 ,  A61L27/042 ,  A61L27/12 ,  A61L27/54 ,  A61P19/00 ,  A61L2300/232 ,  A61L2300/412 ,  A61L2430/02

摘要： A magnetic biomolecule-metal ion self-assembly complex for treatment includes an iron ion; and at least one ligand, wherein the ligand and the iron ion are reversibly self-assembled with each other or self-disassembled from each other, wherein the ligand and the iron ion are self-assembled with each other via a first bond to form a self-assembly, wherein the self-assembling is performed by at least one of the metal ion and the ligand, wherein the self-assembly includes a plural of self-assemblies, wherein the self-assemblies adjacent to each other self-bind to each other via a second bond to form the self-assembly complex. The magnetic biomolecule-metal ion self-assembly complex is effectively used for cancer treatment, osteoarthritis treatment, and bone defect treatment.

公开(公告)号：US20240269353A1

公开(公告)日：2024-08-15

申请号：US18562945

申请日：2022-05-23

申请人： Know Bio, LLC

发明人： Mark Tapsak ,  Alice Widman ,  Andrew P. Gaudet De Lestard

IPC分类号： A61L31/16 ,  A61B5/145 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L31/16 ,  A61B5/14532 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/114 ,  A61L2420/04

摘要： Nitric oxide releasing particles, coatings, tapes, monoliths, and sprayable formulations for reducing the normal foreign body response (FBR) to implanted materials, enhancing wound healing, and/or increasing vascularization. The particles, coatings, tapes, monoliths, and sprayable formulations comprise a biodegradable polymer and an NO-releasing donor compound, and/or are formed of a biodegradable polymer with pendant NO-releasing functional groups.

公开(公告)号：US20240269351A1

公开(公告)日：2024-08-15

申请号：US18237744

申请日：2023-08-24

申请人： The Johns Hopkins University

发明人： Sashank Reddy ,  Russell Martin ,  Xiaowei Li ,  Calvin Chang ,  Kevin Colbert ,  Hai-Quan Mao

IPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/38 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/20 ,  A61L27/3808 ,  A61L27/3834 ,  A61L27/3895 ,  A61L27/44 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61M5/19 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/622 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/34 ,  A61M2202/08 ,  A61M2202/09 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

摘要： A soft tissue device can incorporate a composite material comprising a gel and at least one nanostructure disposed within the gel. A soft tissue device can further incorporate biologically active materials such as cells, tissues. A method for healing a soft tissue defect while promoting soft tissue regeneration can include applying a soft tissue device to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a soft tissue device for use in healing soft tissue defects can include providing a gel, disposing nanofibers within the gel, and a biologically active material.

公开(公告)号：US20240261470A1

公开(公告)日：2024-08-08

申请号：US18106115

申请日：2023-02-06

申请人： Medos International Sàrl

发明人： Ravi PATEL ,  Jordan JACOBS ,  Michael J. ROMANKO ,  Austin BRIDGES ,  Terry DAGLOW ,  Frederick E. SHELTON, IV ,  Jason L. HARRIS

IPC分类号： A61L27/36 ,  A61L27/54

CPC分类号： A61L27/3654 ,  A61L27/54 ,  A61L2300/602

摘要： An implant for releasing one or more substances within the body is provided. The implant can include a scaffold configured to be implanted within the body to provide a foundation for an implant that provides structural support for promoting meniscus repair and regeneration. The scaffold can be loaded with medicants and/or analgesics that are capable of being released from the implant following implantation to promote healing and reduce inflammation post-surgery. The scaffold can be refilled with substances once implanted. For example, the implant can be connected to an access port that is embedded in the skin to allow refilling of the scaffold. In some embodiments, the scaffold can include a plurality of chambers that are configured to retain a separate substances therein.

公开(公告)号：US20240261086A1

公开(公告)日：2024-08-08

申请号：US18434530

申请日：2024-02-06

申请人： Cannuflow, Inc.

发明人： Theodore R. Kucklick

IPC分类号： A61F2/08 ,  A61F2/00 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54

CPC分类号： A61F2/0811 ,  A61L27/18 ,  A61L27/34 ,  A61L27/54 ,  A61F2002/0081 ,  A61F2002/0852 ,  A61F2002/0888 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2240/001 ,  A61L2430/10

摘要： A biological patch or construct used in tissue engineering for tendon repair. The patch system includes a scaffold connected to at least one fastener via a suture. The patch is delivered to a torn tendon via a delivery cannula and left over a torn tendon to assist in repair of the tendon.

公开(公告)号：US20240252310A1

公开(公告)日：2024-08-01

申请号：US18633919

申请日：2024-04-12

申请人： California LASIK & Eye, Inc.

发明人： Bradley P. Barnett

IPC分类号： A61F2/16 ,  A61L27/54

CPC分类号： A61F2/1648 ,  A61F2/1624 ,  A61F2/1602 ,  A61F2002/1682 ,  A61F2002/16902 ,  A61L27/54

摘要： An exchangeable optics system includes magnetic fixation points that are anchored to the outside of the eye. The fixation points can include magnetic barbed tacks, magnetic soft tissue screws, or a sclera buckle with permanent magnets. Fiducials on the fixation points help with visibility during implantation of an exchangeable intraocular lens (IOL) or other devices. The exchangeable optic can be suspended within the eye by way of tethers having ends of magnetic metal or permanent magnetic material that magnetically couple with the magnetic fixation points. The lengths of the suspension tethers can be adjusted in small increments with other magnets in order to place the lens into position with a proper three-dimensional orientation within the eye.