公开(公告)号：US11971337B2

公开(公告)日：2024-04-30

申请号：US17493477

申请日：2021-10-04

Applicant: Ventana Medical Systems, Inc.

Inventor： James Grille ,  Brian D. Kelly ,  Jerome Kosmeder, II ,  Eric May ,  Noemi Sebastiao ,  Pamela Wirth

IPC: G01N1/30 ,  A61K49/00 ,  C01B15/01 ,  C01B21/08 ,  C07C55/02 ,  C07C55/22 ,  C07C55/24 ,  C12N9/99 ,  G01N33/52

CPC classification number: G01N1/30 ,  C01B15/01 ,  C01B21/08 ,  C07C55/02 ,  C07C55/22 ,  C07C55/24 ,  C12N9/99 ,  G01N33/52 ,  A61K49/001 ,  G01N2001/302 ,  G01N2333/902 ,  G01N2333/908 ,  G01N2333/916

Abstract: Disclosed are compositions and methods for inactivating one or more enzymes in a biological sample.

公开(公告)号：US20240125785A1

公开(公告)日：2024-04-18

申请号：US18398016

申请日：2023-12-27

Applicant: Laboratory Corporation of America Holdings

Inventor： Gerald J. Wallweber

IPC: G01N33/574 ,  C12Q1/6886 ,  G01N33/52

CPC classification number: G01N33/57407 ,  C12Q1/6886 ,  G01N33/52 ,  G01N33/5748 ,  C12Q2600/158

Abstract: Disclosed are compositions and methods to detect proteins associated with Head and Neck Cancer, generally, or more particularly, biomarkers of Head and Neck Squamous Cell Carcinoma (HNSCC). Such markers may be useful to allow individuals susceptible to HNSCC to manage their lifestyle and/or medical treatment to avoid further progression of disease.

公开(公告)号：US11959923B2

公开(公告)日：2024-04-16

申请号：US17314254

申请日：2021-05-07

Applicant: Cambridge Enterprise Limited

Inventor： Emma Yates ,  Christopher Dobson ,  Therese Herling ,  Tuomas Pertti Jonathan Knowles

IPC: G01N33/68 ,  B01L3/00 ,  G01N15/02 ,  G01N27/447 ,  G01N33/50 ,  G01N33/52 ,  G01N15/00

CPC classification number: G01N33/6845 ,  B01L3/502753 ,  G01N15/0266 ,  G01N27/447 ,  G01N33/50 ,  G01N33/52 ,  B01L2200/0631 ,  B01L2200/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0421 ,  G01N2015/0038 ,  G01N2015/0288

Abstract: Flow apparatuses comprising a separation channel, a downstream flow separator, a detection zone, an observation zone, and a waste channel. The separation channel has first and second flows in contact and allows lateral movement of components between contacting first and second flows. The downstream flow separator is in communication with the separation channel and diverts a part of the first fluid flow, the second fluid flow, or both, from the separation channel. The detection zone comprises a detection channel downstream of and in communication with the flow separator and configured to receive a plurality of diverted flows from the flow separator and a label channel configured to label the diverted flows from the flow separator. The observation zone is configured to record an analytical signal indicative of the quantity and the electrical properties of the component. The waste channel is at the downstream end of the observation zone.

公开(公告)号：US20240091305A1

公开(公告)日：2024-03-21

申请号：US18454391

申请日：2023-08-23

Applicant: TIMSER, S.A.P.I. DE C.V.

Inventor： Alberto CHECA ROJAS ,  Orlando SANTILLAN GODINEZ ,  Raul DOMINGUEZ PALESTINO

IPC: A61K38/16 ,  G01N33/52 ,  G01N33/53 ,  G01N33/574

CPC classification number: A61K38/16 ,  G01N33/52 ,  G01N33/53 ,  G01N33/57411

Abstract: The present invention is related to diagnostic tests or rapid detections of different types of cancer, especially cervical cancer and precancerous lesions. Especially, the invention relates to specific and useful protein biomarkers for the detection of said diseases, and to the methods for determination and detection of said biomarkers.

公开(公告)号：US20230417643A1

公开(公告)日：2023-12-28

申请号：US18366846

申请日：2023-08-08

Applicant: CytoChip Inc.

Inventor： Wendian Shi

IPC: G01N15/02 ,  G01N15/14 ,  G01N33/52

CPC classification number: G01N15/0205 ,  G01N15/1436 ,  G01N2015/0073 ,  G01N33/52 ,  G01N15/1459

Abstract: The disclosure provides devices, device systems, and methods for analyzing cells (e.g., blood cells) or particles in a sample. In some embodiments, the disclosure provides various devices and device systems including: a light source; a collecting lens; and one, two, or more detectors. In other embodiments, the devices and device systems include a flow cell or a cartridge device with a flow cell. In further embodiments, the disclosure provides various methods including the steps of: using a light source to emit an irradiation light; using the irradiation light to illuminate a sample flow; using a collecting lens to collect both scattered light and fluorescent light from the sample flow; and using one, two, or more detectors to detect the collected scattered light and fluorescent light. Optionally, these methods include using a flow cell to form a sample flow.

公开(公告)号：US20230324358A1

公开(公告)日：2023-10-12

申请号：US17979453

申请日：2022-11-02

Applicant: Ken-ichi YAMADA ,  FUSO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： Ken-ichi YAMADA ,  Saki SHINTO ,  Tomomi IDE ,  Keiichi YAMAMOTO

IPC: C07D413/12 ,  G01N33/15 ,  C01G49/14 ,  C40B20/08 ,  G01N33/52 ,  C07C57/00 ,  C12N5/071

CPC classification number: G01N33/15 ,  C01G49/14 ,  C07C57/00 ,  C07D413/12 ,  C12N5/067 ,  C40B20/08 ,  G01N33/52

Abstract: The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.

公开(公告)号：US11768143B2

公开(公告)日：2023-09-26

申请号：US17456414

申请日：2021-11-24

Applicant: CytoChip Inc.

Inventor： Wendian Shi

IPC: G01N15/02 ,  G01N15/14 ,  G01N33/52 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N15/0205 ,  G01N15/1436 ,  G01N15/1459 ,  G01N33/52 ,  G01N2015/0073 ,  G01N2015/1006 ,  G01N2015/1087 ,  G01N2015/1493

Abstract: The disclosure provides devices, device systems, and methods for analyzing cells (e.g., blood cells) or particles in a sample. In some embodiments, the disclosure provides various devices and device systems including: a light source; a collecting lens; and one, two, or more detectors. In other embodiments, the devices and device systems include a flow cell or a cartridge device with a flow cell. In further embodiments, the disclosure provides various methods including the steps of: using a light source to emit an irradiation light; using the irradiation light to illuminate a sample flow; using a collecting lens to collect both scattered light and fluorescent light from the sample flow; and using one, two, or more detectors to detect the collected scattered light and fluorescent light. Optionally, these methods include using a flow cell to form a sample flow.

公开(公告)号：US11754564B2

公开(公告)日：2023-09-12

申请号：US17206399

申请日：2021-03-19

Applicant: HEALTHY.IO LTD.

Inventor： Bernard Burg ,  Martin Zizi ,  Walter De Brouwer ,  Jaime Tenedorio ,  Babak Aghazadeh ,  Jie Cui ,  Sheena Menezes

IPC: G01N21/78 ,  G01N21/79 ,  G01N21/80 ,  G01N21/81 ,  G01N21/84 ,  G01N33/52 ,  G06T7/90 ,  G01N33/543

CPC classification number: G01N33/54388 ,  G01N21/78 ,  G01N21/79 ,  G01N21/80 ,  G01N21/81 ,  G01N21/8483 ,  G01N33/52 ,  G06T7/90 ,  G01N2021/8488 ,  G01N2021/8494

Abstract: A reagent test paddle includes a contamination detection medium, a reference color bar, at least one chemical test medium, and a unique identifier. The contamination detection medium includes a reagent that changes color in the presence or when exposed to a hostile or inhospitable environment. Each chemical test medium includes a regent that is responsive to a respective analyte in a biological sample. The reference color bar includes reference color samples of different colors. The unique identifier, like a serial number, identifies the particular paddle and its chemical test medium so it can be uniquely and anonymously associated with a user. A method includes capturing and interpreting digital images of a biologically unexposed and subsequently exposed reagent test paddle at various delay times within an automatically calibrated environment; locating the paddle in a plurality of digital images, extracting the reference color bar and locating the contamination detection medium and chemical test medium in each digital image. Color changes of the chemical test medium and contamination medium are detected at various delay times after sample exposure. To determine validity of test results, the method further compares the detected colors of the contamination detection medium with predetermined colors expected for no contamination and contamination.

公开(公告)号：US20230268057A1

公开(公告)日：2023-08-24

申请号：US18141842

申请日：2023-05-01

Applicant: HEALTHY.IO LTD.

Inventor： Ron ZOHAR ,  Yonatan ADIRI ,  Eitan GUR

IPC: G16H30/40 ,  G16H40/20 ,  G16H10/60 ,  G01N33/70 ,  G01N33/483 ,  G06Q40/08 ,  G06T7/00 ,  G01N1/12 ,  G01N21/78 ,  G01N33/487 ,  G01N33/493 ,  G01N33/52 ,  G01N33/68 ,  G16H10/40 ,  G16H30/20 ,  G01N33/50 ,  H04L9/40 ,  H04W4/12 ,  H04W12/06 ,  G06T7/90 ,  G16H70/00 ,  G06F16/583 ,  A61B5/103 ,  A61B5/00 ,  G06Q20/38 ,  G06T7/73 ,  G06T7/11

CPC classification number: G16H30/40 ,  G16H40/20 ,  G16H10/60 ,  G01N33/70 ,  G01N33/4833 ,  G06Q40/08 ,  G06T7/0012 ,  G01N1/12 ,  G01N21/78 ,  G01N33/48778 ,  G01N33/493 ,  G01N33/52 ,  G01N33/6827 ,  G16H10/40 ,  G16H30/20 ,  G01N33/5094 ,  G01N33/6803 ,  G06T7/0016 ,  H04L63/126 ,  H04W4/12 ,  H04W12/06 ,  G06T7/90 ,  G16H70/00 ,  G06F16/5838 ,  A61B5/1034 ,  A61B5/445 ,  G06Q20/385 ,  G06T7/74 ,  G06T7/11 ,  G06T7/0014 ,  A61B5/0013 ,  G06T2207/10024 ,  G16H15/00

Abstract: Systems and methods for tracking healing progress of multiple adjacent wounds are provided. In one embodiment, a system may include a processor configured to receive a first image of a plurality of adjacent wounds near a form of colorized surface having colored reference elements, determine colors of the plurality of wounds, correct for local illumination conditions, receive a second image of the plurality of wounds near the form of colorized surface, to determine second colors of the plurality of wounds in the second image, match each of the plurality of wounds in the second image to a wound of the plurality of wounds in the first image, and determine an indicator of the healing progress for each of the plurality of wounds based on changes between the first image and the second image.

公开(公告)号：US20230265483A1

公开(公告)日：2023-08-24

申请号：US18010076

申请日：2021-06-10

Applicant: Alexion Pharmaceuticals, Inc.

Inventor： Joel Freeberg ,  Genmin Lu ,  Pamela Conley

IPC: C12Q1/56 ,  G01N33/52 ,  G01N33/86

CPC classification number: C12Q1/56 ,  G01N33/52 ,  G01N33/86

Abstract: The present disclosure relates kits and methods for measuring the potency of an andexanet sample in neutralizing a factor Xa inhibitor and restoring the activity of a wild-type factor Xa.