公开(公告)号：US20170248613A1

公开(公告)日：2017-08-31

申请号：US15589836

申请日：2017-05-08

申请人： ASTUTE MEDICAL, INC.

发明人： Joseph Anderberg ,  Jeff Gray ,  Paul McPherson ,  Kevin Nakamura ,  James Patrick Kampf

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/475 ,  G01N2333/49 ,  G01N2333/52 ,  G01N2333/521 ,  G01N2333/54 ,  G01N2333/5418 ,  G01N2333/71 ,  G01N2333/7155 ,  G01N2333/96494 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Thymic stromal lymphopoietin, Vascular endothelial growth factor receptor 1, C-C motif chemokine 1, C-C motif chemokine 17, C-C motif chemokine 21, C-C motif chemokine 27, FLT-3 Ligand, Immunoglobulin G subclass 3, Interleukin-1 receptor type I, Interleukin-20, Interleukin-29, Interleukin-7, Platelet-derived growth factor A/B dimer, Platelet-derived growth factor A/A dimer, and MMP9:TIMP2 complex as diagnostic and prognostic biomarkers in renal injuries.

公开(公告)号：US09696310B2

公开(公告)日：2017-07-04

申请号：US14738894

申请日：2015-06-14

申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.

发明人： David Margulies ,  Leila Motiei ,  Linor Unger

IPC分类号： C07D417/14 ,  G01N33/573 ,  C07D417/06 ,  C09K11/06 ,  G01N33/58 ,  C07F9/6541 ,  C07K7/06 ,  G01N33/574

CPC分类号： G01N33/573 ,  C07D417/06 ,  C07D417/14 ,  C07F9/6541 ,  C07K7/06 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1037 ,  G01N33/574 ,  G01N33/582 ,  G01N2333/91177 ,  G01N2333/918 ,  G01N2333/96494

摘要： The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

公开(公告)号：US20170183421A1

公开(公告)日：2017-06-29

申请号：US15376232

申请日：2016-12-12

申请人： Gilead Biologics, Inc.

发明人： Victoria Smith ,  Scott McCauley

IPC分类号： C07K16/40 ,  G01N33/573

CPC分类号： C07K16/40 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/6491 ,  C12Y304/24035 ,  G01N33/573 ,  G01N2333/96494

摘要： The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

公开(公告)号：US09550836B2

公开(公告)日：2017-01-24

申请号：US14382301

申请日：2012-02-29

申请人： Victoria Smith ,  Scott McCauley

发明人： Victoria Smith ,  Scott McCauley

IPC分类号： G01N33/53 ,  C07K16/40 ,  C12N9/64 ,  G01N33/573 ,  A61K39/00

CPC分类号： C07K16/40 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/6491 ,  C12Y304/24035 ,  G01N33/573 ,  G01N2333/96494

摘要： The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

摘要翻译： 本公开提供涉及结合基质金属蛋白酶-9（MMP9）蛋白（MMP9也称为明胶酶-B））的结合蛋白质（例如抗体及其抗原结合片段）的组合物和使用方法，例如其中 结合蛋白质包含免疫球蛋白（Ig）重链（或其功能片段）和Ig轻链（或其功能片段）。

公开(公告)号：US20170002429A1

公开(公告)日：2017-01-05

申请号：US15250593

申请日：2016-08-29

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Michael Stürzl ,  Roland S. Croner ,  Andreas Konrad

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57419 ,  G01N2333/78 ,  G01N2333/96494 ,  G01N2800/50 ,  G06F19/00 ,  G16H50/30 ,  Y02A90/26

摘要： The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. The products and methods of the present invention include detecting the level of expression of COL10A1 or MMP11, in combination, from samples, including tissue samples, from humans who currently have been diagnosed with cancer or who were previously diagnosed with cancer and those who are thought to have cancer and are undergoing diagnosis.

摘要翻译： 本发明涉及结肠直肠癌检测方法和产品。 此外，本发明涉及用于确定结肠直肠癌和结肠直肠癌转移的概率，风险或发生率的方法和产品。 本发明的产品和方法包括从目前被诊断患有癌症的人或以前被诊断患有癌症的人的样本，包括组织样本的组合中组合检测COL10A1或MMP11的表达水平，以及被认为是癌症的人 患有癌症并正在接受诊断。

公开(公告)号：US20160033536A1

公开(公告)日：2016-02-04

申请号：US14847854

申请日：2015-09-08

申请人： Rules-Based Medicine, Inc.

发明人： Cristopher McReynolds ,  David M. Rocke ,  Lynn Kozma ,  Anton Wyss-Coray

IPC分类号： G01N33/68 ,  G06F19/24

CPC分类号： G01N33/6896 ,  G01N2333/4737 ,  G01N2333/50 ,  G01N2333/523 ,  G01N2333/7151 ,  G01N2333/775 ,  G01N2333/96494 ,  G01N2800/2821 ,  G01N2800/60 ,  G16B40/00

摘要： The inventors have discovered sets of proteinaceous biomarkers which can be measured in biological fluid samples to diagnosis or aid in the diagnosis of Alzheimer's disease and distinguish AD samples from non-demented samples.

摘要翻译： 本发明人已经发现了可以在生物流体样品中测量的蛋白质生物标志物集合，以诊断或帮助诊断阿尔茨海默病并区分AD样品与非痴呆样品。

公开(公告)号：US20150377909A1

公开(公告)日：2015-12-31

申请号：US14832427

申请日：2015-08-21

申请人： Crescendo Bioscience ,  Oklahoma Medical Research Foundation

发明人： Guy L. Cavet ,  Yijing Shen ,  Nicholas Knowlton ,  Michael Centola

IPC分类号： G01N33/68 ,  G06F19/24

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/564 ,  G01N2333/4709 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70578 ,  G01N2333/72 ,  G01N2333/96494 ,  G01N2800/102 ,  G01N2800/60 ,  G16B40/00

摘要： Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).

摘要翻译： 提供了用于诊断和评估炎性疾病的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 生物标志物包括至少两种选自DAIMRK组的生物标志物，得分是疾病活动指数（DAI）。

公开(公告)号：US09200324B2

公开(公告)日：2015-12-01

申请号：US12905984

申请日：2010-10-15

申请人： Guy L. Cavet ,  Yijing Shen ,  Nicholas Knowlton ,  Michael Centola

发明人： Guy L. Cavet ,  Yijing Shen ,  Nicholas Knowlton ,  Michael Centola

IPC分类号： G01N33/53 ,  G01N33/00 ,  G01N33/543 ,  G01N33/564 ,  C12Q1/68 ,  G06F19/24

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/564 ,  G01N2333/4709 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70578 ,  G01N2333/72 ,  G01N2333/96494 ,  G01N2800/102 ,  G01N2800/60 ,  G06F19/24

摘要： Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).

摘要翻译： 提供了用于诊断和评估炎性疾病的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 生物标志物包括至少两种选自DAIMRK组的生物标志物，得分是疾病活动指数（DAI）。

公开(公告)号：US09182401B2

公开(公告)日：2015-11-10

申请号：US13002170

申请日：2009-07-06

申请人： Serge Bottari

发明人： Serge Bottari

IPC分类号： G01N33/573 ,  C07K16/40 ,  G01N33/574 ,  G01N33/68

CPC分类号： G01N33/574 ,  C07K16/40 ,  G01N33/689 ,  G01N2333/471 ,  G01N2333/96494 ,  G01N2800/368

摘要： The use of the IRAP protein for implementing methods of diagnosis and of prognosis.

摘要翻译： 使用IRAP蛋白进行诊断和预后的方法。

公开(公告)号：US20150177244A1

公开(公告)日：2015-06-25

申请号：US14576967

申请日：2014-12-19

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Bruce Xuefeng Ling ,  Karl G. Sylvester ,  Changlin Fu ,  Shan Xiang Wang ,  Dokyoon Kim

IPC分类号： G01N33/573 ,  G01N33/68

CPC分类号： G01N33/573 ,  G01N33/6893 ,  G01N2333/4737 ,  G01N2333/70503 ,  G01N2333/96494 ,  G01N2800/067 ,  G01N2800/26

摘要： Methods and compositions are provided for making a necrotizing enterocolitis (NEC) or sepsis assessment of an individual. Aspects of the methods include detecting a biomarker or panel of biomarkers selected from MMP7, EpCAM, and CRP. In addition, reagents, devices, systems and kits thereof that find use in practicing the subject methods are provided.

摘要翻译： 提供了用于制备坏死性小肠结肠炎（NEC）或个体败血症评估的方法和组合物。 方法的方面包括检测选自MMP7，EpCAM和CRP的生物标志物的生物标志物或组。 此外，还提供了用于实践本发明方法的试剂，装置，系统和试剂盒。