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公开(公告)号：US11639929B2
公开(公告)日：2023-05-02
申请号：US16783524
申请日：2020-02-06
发明人： David Margulies , Leila Motiei , Naama Lahav
IPC分类号： C07D249/04 , G01N33/533 , G01N33/68 , G01N33/58
摘要： This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.
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公开(公告)号：US20150276753A1
公开(公告)日：2015-10-01
申请号：US14738894
申请日：2015-06-14
发明人： David MARGULIES , Leila Motiei , Linor Unger
IPC分类号： G01N33/58 , C07F9/6541 , C07D417/06 , C07D417/14 , G01N33/573
CPC分类号： G01N33/573 , C07D417/06 , C07D417/14 , C07F9/6541 , C07K7/06 , C09K11/06 , C09K2211/1029 , C09K2211/1037 , G01N33/574 , G01N33/582 , G01N2333/91177 , G01N2333/918 , G01N2333/96494
摘要： The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.
摘要翻译： 本发明涉及基于噻唑橙用于蛋白质检测的荧光分子传感器。 蛋白质靶标与本发明的分子传感器的相互作用导致荧光发射的显着增加。 光输出信号的产生使得人们能够检测与不同疾病相关的蛋白质生物标志物或检测活细胞中感兴趣的蛋白质。
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3.发明授权公开(公告)号：US10557852B2
公开(公告)日：2020-02-11
申请号：US15307011
申请日：2015-04-28
摘要： This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.
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公开(公告)号：US10281459B2
公开(公告)日：2019-05-07
申请号：US14754785
申请日：2015-06-30
发明人： David Margulies , Leila Motiei , Zohar Pode
IPC分类号： C07K7/06 , G01N33/58 , G01N33/53 , C07D417/06 , C07D417/14 , C07F9/6541 , G01N33/574 , G01N33/573 , C09K11/06
摘要： The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.
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公开(公告)号：US09696310B2
公开(公告)日：2017-07-04
申请号：US14738894
申请日：2015-06-14
发明人： David Margulies , Leila Motiei , Linor Unger
IPC分类号： C07D417/14 , G01N33/573 , C07D417/06 , C09K11/06 , G01N33/58 , C07F9/6541 , C07K7/06 , G01N33/574
CPC分类号： G01N33/573 , C07D417/06 , C07D417/14 , C07F9/6541 , C07K7/06 , C09K11/06 , C09K2211/1029 , C09K2211/1037 , G01N33/574 , G01N33/582 , G01N2333/91177 , G01N2333/918 , G01N2333/96494
摘要： The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.
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公开(公告)号：US20230366885A1
公开(公告)日：2023-11-16
申请号：US18350066
申请日：2023-07-11
发明人： David MARGULIES , Leila Motiei , Naama Lahav , Pragati Prasad
IPC分类号： G01N33/58 , G01N33/574
CPC分类号： G01N33/582 , G01N33/574
摘要： The disclosure presented herein provides DNA constructs, recombinant cells comprising thereof, system comprising thereof, bacterial probes, and/or a recombinant cell decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying cells, preferably bacteria cells, and methods for using thereof.
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公开(公告)号：US10557853B2
公开(公告)日：2020-02-11
申请号：US15640545
申请日：2017-07-02
发明人： David Margulies , Leila Motiei , Linor Unger
IPC分类号： C07D417/06 , G01N33/58 , C07D417/14 , C07K7/06 , C09K11/06 , G01N33/573 , G01N33/574
摘要： The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.
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8.发明申请PROTEIN BIOSENSORS, CROSS REACTIVE SENSOR ARRAYS AND METHODS OF USE THEREOF 审中-公开蛋白生物传感器，交叉反应传感器阵列及其使用方法公开(公告)号：US20150362490A1
公开(公告)日：2015-12-17
申请号：US14754785
申请日：2015-06-30
发明人： David MARGULIES , Leila Motiei , Zohar Pode
IPC分类号： G01N33/573 , C07K7/06
CPC分类号： G01N33/53 , C07D417/06 , C07D417/14 , C07F9/6541 , C07K7/06 , C09K11/06 , C09K2211/1029 , C09K2211/1037 , G01N33/573 , G01N33/574 , G01N33/582 , G01N2333/91177 , G01N2333/918 , G01N2333/96494
摘要： The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.
摘要翻译： 本发明涉及基于寡核苷酸交叉反应性传感器阵列的荧光蛋白生物传感器，其包括用于蛋白质检测的选择性和非选择性蛋白质表面结合结构域。 不同蛋白质同种型与本发明传感器的相互作用产生了每种蛋白质独特的光学特征。 独特的光学特征允许区分密切相关的蛋白质同种型，并在生物流体中诊断与蛋白质相关的疾病和病症。
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