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公开(公告)号：US20170168070A1
公开(公告)日：2017-06-15
申请号：US15388358
申请日：2016-12-22
发明人： Pankaj Oberoi , Steven C. Hoffmann , Guy L. Cavet , Yijing Shen , Nicholas Knowlton , Michael Centola
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/53 , G01N33/564 , G01N2333/4709 , G01N2333/4737 , G01N2333/475 , G01N2333/485 , G01N2333/5412 , G01N2333/70503 , G01N2333/70578 , G01N2333/72 , G01N2333/96494 , G01N2800/102 , G01N2800/60 , G16B40/00
摘要： Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
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2.发明申请Biomarkers and Methods for Measuring and Monitoring Inflammatory Disease Activity 审中-公开生物标志物和测量和监测炎症疾病活动的方法公开(公告)号：US20170074878A1
公开(公告)日：2017-03-16
申请号：US15363991
申请日：2016-11-29
发明人： Pankaj Oberoi , Steven C. Hoffmann , Guy L. Cavet , Yijing Shen , Nicholas Knowlton , Michael Centola
IPC分类号： G01N33/564
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/53 , G01N33/564 , G01N2333/4709 , G01N2333/4737 , G01N2333/475 , G01N2333/485 , G01N2333/5412 , G01N2333/70503 , G01N2333/70578 , G01N2333/72 , G01N2333/96494 , G01N2800/102 , G01N2800/60 , G16B40/00
摘要： Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
摘要翻译： 提供了用于诊断和评估炎性疾病的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 生物标志物包括至少两种选自DAIMRK组的生物标志物，得分是疾病活动指数（DAI）。
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公开(公告)号：US11300575B2
公开(公告)日：2022-04-12
申请号：US14832427
申请日：2015-08-21
发明人： Guy L. Cavet , Yijing Shen , Nicholas Knowlton , Michael Centola
IPC分类号： G01N33/68 , G01N33/53 , G16B40/00 , G16B40/20 , G01N33/564 , C12Q1/6883
摘要： Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
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4.发明申请BIOMARKERS AND METHODS FOR MEASURING AND MONITORING INFLAMMATORY DISEASE ACTIVITY 审中-公开生物标记和测量和监测炎症疾病活动的方法公开(公告)号：US20150377909A1
公开(公告)日：2015-12-31
申请号：US14832427
申请日：2015-08-21
发明人： Guy L. Cavet , Yijing Shen , Nicholas Knowlton , Michael Centola
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/53 , G01N33/564 , G01N2333/4709 , G01N2333/4737 , G01N2333/475 , G01N2333/485 , G01N2333/5412 , G01N2333/70503 , G01N2333/70578 , G01N2333/72 , G01N2333/96494 , G01N2800/102 , G01N2800/60 , G16B40/00
摘要： Biomarkers useful for diagnosing and assessing inflammatory disease are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. The biomarkers include at least two biomarkers selected from the DAIMRK group and the score is a disease activity index (DAI).
摘要翻译： 提供了用于诊断和评估炎性疾病的生物标志物，以及用于测量其表达的试剂盒。 本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。 生物标志物包括至少两种选自DAIMRK组的生物标志物，得分是疾病活动指数（DAI）。
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