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公开(公告)号：US20170239394A1
公开(公告)日：2017-08-24
申请号：US15513603
申请日：2015-09-21
CPC分类号： A61L27/54 , A61L27/045 , A61L27/28 , A61L27/306 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2420/02 , A61L2430/02 , A61L2430/12
摘要： The present invention relates to orthopedic implants, in particular to hip and knee prostheses, substantially involving metallic substrates with an antibacterial surface treatment consisting of silver immobilized in an organic linker and ligand via a multistep solution dipping and drying process. This treatment while being biocompatible is designed to inhibit bacterial growth and therefore combat periprosthetic infection which is one of the main causes of revision in hip and knee arthroplasty.
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152.发明申请公开(公告)号：US20170232144A1
公开(公告)日：2017-08-17
申请号：US15502633
申请日：2015-08-17
申请人： THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY
发明人： Daniel John KELLY , Grainne CUNNIFFE , Henrique ALMEIDA , Rajalakshmanan ESWARAMOORTHY , Conor BUCKLEY , Pedro DIAZ PEYNO , David BROWE
CPC分类号： A61L27/3633 , A61L27/3612 , A61L27/365 , A61L27/3654 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L27/3817 , A61L27/3821 , A61L27/3847 , A61L27/3852 , A61L27/44 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/64 , A61L2430/02 , A61L2430/06 , A61L2430/40
摘要： A method for making a porous devitalised scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal comprises the steps of providing micronized extracellular matrix (ECM) tissue, mixing the micronized extracellular matrix with a liquid to provide a slurry, and freeze-drying the slurry to provide the porous scaffold. A porous scaffold suitable for use in repair of osseous, chondral, or osteochondral defects in a mammal and comprising a porous freeze-dried matrix formed from micronised decellularised extracellular matrix tissue is also described.
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公开(公告)号：US20170232143A1
公开(公告)日：2017-08-17
申请号：US15409392
申请日：2017-01-18
发明人： Kristi ANSETH , Ben FAIRBANKS , Christopher BOWMAN
CPC分类号： A61L27/18 , A61L27/22 , A61L27/52 , A61L27/54 , A61L2430/02 , A61L2430/06 , A61L2430/34 , C08F38/00 , C08G75/045 , C08G75/12 , C08J3/075 , C08J2300/16 , C08J2300/20 , C08J2371/02 , C08L81/02 , C08L101/02 , C08L101/16 , C12N5/0068
摘要： A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol functional groups. The alkyne moiety, internal or terminal, may react with one or two thiols. Degradable monomers may be used to form degradable polymers.
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公开(公告)号：US09731045B2
公开(公告)日：2017-08-15
申请号：US14148617
申请日：2014-01-06
发明人： Kenneth Gall , Christopher Yakacki
CPC分类号： A61L27/16 , A61B17/0401 , A61B2017/00871 , A61B2017/0448 , A61F2/0811 , A61F2002/0835 , A61F2002/0858 , A61F2002/0864 , A61F2002/0882 , A61F2002/0888 , A61F2210/0014 , A61L27/50 , A61L2400/16 , A61L2430/02
摘要： A polymer is composed of a linear chain acrylate and a multi-functional acrylate cross-linker. The polymerized composition exhibits a transition at a temperature between about 34° C. and about 50° C. The polymerized composition exhibits shape memory effects. In one embodiment, the linear chain is tert-butyl acrylate and the crosslinker is polyethylene glycol dimethacrylate. The resultant shape memory polymers may be used in medical devices to provide devices with different shapes for pre and post implantation.
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公开(公告)号：US09730982B2
公开(公告)日：2017-08-15
申请号：US14492957
申请日：2014-09-22
发明人： William F. McKay , Jeffrey L. Scifert , Kathy Remsen , Didier Billy , Mirian Gillissen , Scott M. Vickers
CPC分类号： A61K38/1875 , A61K9/0024 , A61L27/26 , A61L27/54 , A61L2300/414 , A61L2430/02 , C08L5/04 , C08L89/06
摘要： Described are implantable, malleable medical materials comprising mineral particles, insoluble collagen fibers, and a gel-forming polysaccharide component and/or another added gel-former. The malleable medical materials can be used treat bone or other tissue defects in patients, including in conjunction with biologically active factors such as osteogenic proteins. Also described are methods and materials that can be used to prepare the malleable medical materials.
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公开(公告)号：US09730959B2
公开(公告)日：2017-08-15
申请号：US14369008
申请日：2012-12-24
发明人： Artur Aleksandrovich Isaev , Sergej L'vovich Kiselev , Roman Vadimovich Deev , Il'ya Yadigerovich Bozo , Elena Sergeevna Filonenko
IPC分类号： A61K35/12 , A61K47/48 , A61L27/12 , A61L27/24 , A61L27/38 , A61L27/46 , A61L27/54 , A61L27/58 , A61K48/00
CPC分类号： A61K35/12 , A61K47/6901 , A61K47/6923 , A61K48/0041 , A61L27/12 , A61L27/24 , A61L27/3804 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/258 , A61L2300/64 , A61L2400/06 , A61L2430/02 , C08L89/06
摘要： Provided is a biocomposite including cells, a genetic construction, and a scaffold and a method for repairing tissue and organs in mammalians with the biocomposite. The interaction of the components of the biocomposite provides a complex effect on reparative regeneration processes. Also provided is a method for administration of gene-cellular therapeutic constructions to a recipient which can be used in medicine and veterinary to provide reparative processes. After administering the biocomposite to a recipient, the scaffold structure releases the nucleic acids which enter into the cells of a recipient bed and cells of the transplanted product. The nucleic acids are expressed, which results in the increased concentration of a target product responsible for reparative processes.
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157.发明申请公开(公告)号：US20170224458A1
公开(公告)日：2017-08-10
申请号：US15306751
申请日：2015-04-24
发明人： José Miguel GARCÍA MARTÍN , Alberto PALMERO ACEBEDO , Rafael ÁLVAREZ MOLINA , María VALLET-REGÍ , Daniel ARCOS NAVARRETE , Isabel IZQUIERDO BARBA
CPC分类号： A61F2/0077 , A61B17/80 , A61B2017/00889 , A61C8/0013 , A61C13/00 , A61F2/28 , A61F2/2803 , A61F2310/00407 , A61L27/06 , A61L27/30 , A61L27/306 , A61L2420/02 , A61L2430/02 , C23C14/16 , C23C14/165 , C23C14/35
摘要： A new titanium-based implant is disclosed, which is formed by a titanium coating manufactured with biomaterials with applications in osseous implantology. The nanotopographical characteristics of these implants inhibit bacterial adhesion and the formation of a bacterial biofilm on the surface, whilst simultaneously presenting suitable properties for the adhesion, stretching and proliferation of bone-forming cells. Moreover, the invention comprises a method for manufacturing the implant by means of oblique-incidence techniques and the use thereof in osseous implantology.
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公开(公告)号：US09724207B2
公开(公告)日：2017-08-08
申请号：US14934289
申请日：2015-11-06
IPC分类号： A61F2/44 , A61F2/28 , A61F2/46 , A61L27/18 , A61L27/50 , A61L27/54 , A61B17/00 , A61K9/00 , A61K49/00 , A61L27/12 , A61L27/38 , A61L27/52 , A61L27/06 , A61L27/56 , A61F2/30
CPC分类号： A61F2/4455 , A61B17/00234 , A61F2/28 , A61F2/30965 , A61F2/441 , A61F2/442 , A61F2/4425 , A61F2/446 , A61F2/4465 , A61F2/4601 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30065 , A61F2002/30092 , A61F2002/30131 , A61F2002/302 , A61F2002/30224 , A61F2002/3023 , A61F2002/30308 , A61F2002/30383 , A61F2002/30451 , A61F2002/3055 , A61F2002/30556 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30604 , A61F2002/30622 , A61F2002/30841 , A61F2002/30971 , A61F2002/4475 , A61F2002/448 , A61F2002/4627 , A61F2002/4635 , A61F2002/4677 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2210/0071 , A61F2210/0085 , A61F2220/0016 , A61F2220/0025 , A61F2220/0058 , A61F2230/0013 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2250/0003 , A61F2250/0009 , A61F2250/001 , A61F2250/003 , A61F2250/0065 , A61F2310/00011 , A61F2310/00179 , A61F2310/00365 , A61K9/0024 , A61K49/006 , A61L27/06 , A61L27/12 , A61L27/18 , A61L27/3821 , A61L27/3839 , A61L27/3847 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/256 , A61L2300/404 , A61L2300/414 , A61L2300/43 , A61L2300/64 , A61L2430/02 , A61L2430/38
摘要： An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon. In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.
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公开(公告)号：US20170216491A1
公开(公告)日：2017-08-03
申请号：US15008676
申请日：2016-01-28
CPC分类号： A61L27/3691 , A61L2/087 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L2202/11 , A61L2202/21 , A61L2300/412 , A61L2430/02
摘要： A method of making an electron beam irradiated osteoinductive implant is provided. The method comprises exposing an osteoinductive implant containing demineralized bone matrix (DBM) fibers to electron beam radiation at a dose of from about 10 kilograys to 100 kilograys for a period of time. The electron beam irradiation reduces microorganisms in the osteoinductive implant, and the electron beam irradiated osteoinductive implant retains osteoinductive properties. Methods of implantation and an irradiated osteoinductive implant are also disclosed.
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160.发明申请公开(公告)号：US20170209626A1
公开(公告)日：2017-07-27
申请号：US15480698
申请日：2017-04-06
发明人： Roman Vadimovich DEEV , Artur Aleksandrovich ISAEV , llya Yadigerovich BOZO , Vladimir Sergeevich KOMLEV , Alexey Yurevich DROBYSHEV
CPC分类号： A61L27/58 , A61F2/28 , A61K31/7088 , A61K47/50 , A61K48/00 , A61L27/14 , A61L27/3641 , A61L27/54 , A61L2430/02 , B33Y70/00 , B33Y80/00 , C12N15/87
摘要： Provided is a method for construction of bone substitutes efficient in the repair of large bone defects. The method for constructing such medical products includes three-dimensional printing of a bioresorbable scaffold and its activation by gene constructions. Produced medicinal products may serve as an efficient alternative to bone autografts.
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