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112 条记录 (耗时 0.036 秒)

    RAPID ADAPTIVE OPTICAL MICROSCOPY OVER LARGE MULTICELLULAR VOLUMES
    98.
    发明申请
    RAPID ADAPTIVE OPTICAL MICROSCOPY OVER LARGE MULTICELLULAR VOLUMES 有权
    快速自适应光学显微镜在大的多孔体积

    公开(公告)号：US20150362713A1

    公开(公告)日：2015-12-17

    申请号：US14660906

    申请日：2015-03-17

    申请人： Howard Hughes Medical Institute

    发明人： Robert E. Betzig ,  Kai Wang

    IPC分类号： G02B21/00 ,  G01N21/64 ,  G02B21/36

    CPC分类号： G02B21/0064 ,  G01N21/6458 ,  G01N2021/6419 ,  G01N2201/0675 ,  G02B21/0056 ,  G02B21/006 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/361 ,  G02B26/06

    摘要： Excitation light is focused to a focus within a sample and the focus is scanned within a volume in the sample with scanning optical elements. Signal light emitted from the focus is de-scanned, with the one or more scanning optical elements, onto a wavefront sensor as the focus is scanned within the volume. Based on the descanned signal light, an average aberration created by the volume of the sample of a wavefront of the excitation light is determined. A wavefront of the excitation light is corrected by an amount according to the determined average aberration while the focus is scanned within the volume, the signal light is imaged onto a photosensitive detector as the focus is scanned within the volume, and a wavefront of the imaged signal light is corrected by an amount according to the determined average aberration while the focus is scanned. These steps can be repeated for a plurality of different volumes in the sample, and an image of the sample can be generated based on the detected signal light from scanned foci within the different volumes.

    摘要翻译： 激发光聚焦到样品中的焦点，并用扫描光学元件在样品中的体积内扫描焦点。 当聚焦在体积内被扫描时，从焦点发出的信号光与一个或多个扫描光学元件一起被扫描到波前传感器上。 基于下拉信号光，确定由激发光的波前的样本的体积产生的平均像差。 当在体积内扫描焦点时，根据确定的平均像差来校正激发光的波前，当体积内的焦点被扫描时，信号光被成像到光敏检测器上，并且成像的波前 当扫描焦点时，根据确定的平均像差校正信号光的量。 可以对样本中的多个不同体积重复这些步骤，并且可以基于来自不同体积内的扫描焦点的检测到的信号光来生成样本的图像。

    Method and System for Optical Evaluation, and Optical Detector
    99.
    发明申请
    Method and System for Optical Evaluation, and Optical Detector 有权
    光学评估方法与系统及光学检测器

    公开(公告)号：US20150260640A1

    公开(公告)日：2015-09-17

    申请号：US14362392

    申请日：2012-11-30

    申请人： THE UNIVERSITY OF NOTTINGHAM

    发明人： Stephen Sharples ,  Roger Light

    IPC分类号： G01N21/17

    CPC分类号： G01N21/1702 ,  G01H9/00 ,  G01N2201/0612 ,  G01N2201/0675 ,  H01L27/14609

    摘要： An optical detector comprises a plurality of pixels, each pixel comprising a photodiode operable to detect light incident on that pixel and to generate a signal indicative of an intensity of that light. The plurality of pixels comprises a plurality of pixel pairs, and for each pixel pair, in a configuration mode, the detector is arranged to compare the signal generated by a first pixel of the pair with the signal generated by a second pixel of the pair. A method of optical detection is also described, as is a system incorporating the described optical detector.

    摘要翻译： 光学检测器包括多个像素，每个像素包括可操作以检测入射在该像素上的光并产生指示该光强度的信号的光电二极管。 多个像素包括多个像素对，并且对于每个像素对，在配置模式中，检测器被布置为将由该对的第一像素生成的信号与由该对的第二像素生成的信号进行比较。 还描述了光学检测的方法，并且还包括结合所描述的光学检测器的系统。

    Method and system for optical data acquisition and tomography imaging of a turbid medium object
    100.
    发明授权
    Method and system for optical data acquisition and tomography imaging of a turbid medium object 有权
    浑浊介质物质的光学数据采集和层析成像的方法和系统

    公开(公告)号：US09134229B2

    公开(公告)日：2015-09-15

    申请号：US13497290

    申请日：2010-09-22

    申请人： Frédéric Lesage ,  Samuel Bélanger ,  Maxime Abran ,  Jean Provost

    发明人： Frédéric Lesage ,  Samuel Bélanger ,  Maxime Abran ,  Jean Provost

    IPC分类号： G01N21/59 ,  G01N21/47 ,  A61B5/00 ,  G01N21/17

    CPC分类号： G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  G01N21/6456 ,  G01N21/763 ,  G01N2021/1787 ,  G01N2021/479 ,  G01N2201/0675

    摘要： A system and method for optical data acquisition of an illuminated turbid medium object, the system comprises a variable structured light detector and a controller. The light detector is adapted to retrieve light from a plurality of detection points of an output surface of the illuminated turbid medium object with a plurality of detection patterns. The controller is adapted to control the variable structured light detector for the variable structured light detector to use a detection pattern corresponding to an illumination pattern of the illuminated turbid medium object. The light detector is further adapted to optically measure a combination of retrieved light from the plurality of detection points as an optical measurement. The controller is further adapted to store an illumination pattern identifier indicative of the illumination pattern, a detection pattern identifier indicative of the detection pattern and the corresponding optical measurement.

    摘要翻译： 一种用于光学数据采集的照明混浊介质物体的系统和方法，该系统包括可变结构光检测器和控制器。 光检测器适于用多个检测图案从照明的浑浊介质物体的输出表面的多个检测点检索光。 控制器适于控制可变结构光检测器的可变结构光检测器，以使用与照明混浊介质物体的照明图案相对应的检测图案。 光检测器还适于光学测量来自多个检测点的检索光的组合作为光学测量。 控制器还适于存储指示照明模式的照明模式标识符，指示检测模式的检测模式标识符和对应的光学测量。