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91.发明申请公开(公告)号：US20180088347A1
公开(公告)日：2018-03-29
申请号：US15694398
申请日：2017-09-01
Applicant: ASML Netherlands B.V.
Inventor： Gerbrand Van Der Zouw , Martin Jacobus Johan Jak , Martin Ebert
CPC classification number: G02B27/283 , G01J1/08 , G01N21/8806 , G01N21/9501 , G01N2021/8848 , G01N2201/0675 , G02F1/01 , G03F7/70633
Abstract: In an illumination system (12, 13) for a scatterometer, first and second spatial light modulators lie in a common plane and are formed by different portions of a single liquid crystal cell (260). Pre-polarizers (250) apply polarization to first and second radiation prior to the spatial light modulators. A first spatial light modulator (236-S) varies a polarization state of the first radiation in accordance with a first programmable pattern. Second spatial light modulator (236-P) varies a polarization state of the second radiation accordance with a second programmable pattern. A polarizing beam splitter (234) selectively transmits each of the spatially modulated first and second radiation to a common output path, depending on the polarization state of the radiation. In an embodiment, functions of pre-polarizers are performed by the polarizing beam splitter.
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公开(公告)号：US09733177B2
公开(公告)日：2017-08-15
申请号：US14362392
申请日：2012-11-30
Applicant: THE UNIVERSITY OF NOTTINGHAM
Inventor： Stephen Sharples , Roger Light
IPC: G01N21/17 , G01H9/00 , H01L27/146
CPC classification number: G01N21/1702 , G01H9/00 , G01N2201/0612 , G01N2201/0675 , H01L27/14609
Abstract: An optical detector comprises a plurality of pixels, each pixel comprising a photodiode operable to detect light incident on that pixel and to generate a signal indicative of an intensity of that light. The plurality of pixels comprises a plurality of pixel pairs, and for each pixel pair, in a configuration mode, the detector is arranged to compare the signal generated by a first pixel of the pair with the signal generated by a second pixel of the pair. A method of optical detection is also described, as is a system incorporating the described optical detector.
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公开(公告)号：US20170176338A1
公开(公告)日：2017-06-22
申请号：US15384918
申请日：2016-12-20
Applicant: Verily Life Sciences LLC
Inventor： Cheng-Hsun Wu , Victor Marcel Acosta , Ian Peikon , Paul Lebel , Jerrod Joseph Schwartz
CPC classification number: G01N21/6458 , G01J3/0208 , G01J3/021 , G01J3/0224 , G01J3/0229 , G01J3/0237 , G01J3/08 , G01J3/14 , G01J3/18 , G01J3/2823 , G01J3/32 , G01J3/4406 , G01J2003/1213 , G01J2003/2826 , G01N21/6408 , G01N21/6428 , G01N2021/6421 , G01N2021/6441 , G01N2021/6463 , G01N2201/0633 , G01N2201/0675 , G02B5/1828 , G02B21/16 , G02B21/361 , G02B21/367 , G02B26/0808 , G02B26/0833 , G02F1/29 , G02F2201/34 , G02F2203/12 , G06T7/90 , G06T2207/10004 , G06T2207/10056
Abstract: Methods are provided to identify spatially and spectrally multiplexed probes in a biological environment. Such probes are identified by the ordering and color of fluorophores of the probes. The devices and methods provided facilitate determination of the locations and colors of such fluorophores, such that a probe can be identified. In some embodiments, probes are identified by applying light from a target environment to a spatial light modulator that can be used to control the direction and magnitude of chromatic dispersion of the detected light; multiple images of the target, corresponding to multiple different spatial light modulator settings, can be deconvolved and used to determine the colors and locations of fluorophores. In some embodiments, light from a region of the target can be simultaneously imaged spatially and spectrally. Correlations between the spatial and spectral images over time can be used to determine the color of fluorophores in the target.
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公开(公告)号：US20170082546A1
公开(公告)日：2017-03-23
申请号：US15276397
申请日：2016-09-26
Applicant: NIKON CORPORATION
Inventor： Fumihiro DAKE , Hiroki YAZAWA
CPC classification number: G01N21/6458 , G01N21/636 , G01N2201/0675 , G01N2201/0697 , G02B21/0076 , G02B21/0084 , G02B21/086 , G02B21/16 , G02B21/367 , G02B27/58 , G02F1/11
Abstract: A super-resolution observation device includes an illumination optical system that focus a first illuminating light at optical frequency ω1 and a second illuminating light at optical frequency ω2 on a region of an observation object plane; a modulation unit that modulates a property of the first illuminating light heading toward the region at a modulation frequency fm; and an extraction unit that extracts a component at the optical frequency ω1 or ω2 from a light generated in the region according to the first illuminating light and the second illuminating light, the component of which the property changes at a frequency higher than the modulation frequency fm.
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公开(公告)号：US09535247B2
公开(公告)日：2017-01-03
申请号：US15166668
申请日：2016-05-27
Applicant: The Regents of the University of California
Inventor： Xiaodong Tao , Joel A. Kubby
IPC: G01N21/45 , G02B27/00 , G01N21/49 , G01N21/64 , G02B21/16 , G02B21/24 , G02B21/36 , G01J9/00 , G02B27/09 , G01N21/47
CPC classification number: G02B27/0068 , G01J9/00 , G01N21/45 , G01N21/49 , G01N21/6428 , G01N21/6458 , G01N2021/4709 , G01N2021/6439 , G01N2201/06113 , G01N2201/0675 , G01N2201/121 , G02B21/16 , G02B21/244 , G02B21/245 , G02B21/361 , G02B21/365 , G02B27/0927
Abstract: Interferometric focusing (IF), rather than conventional geometric focusing, of excitation light onto a guide-star that is embedded deeply in tissue, increases its fluorescence intensity. The method can extend the depth of wavefront measurement and improve correction inside of tissues because of its ability to suppress both scattering of diffuse light and aberration of ballistic light. The results showed more than two times improvement in SNR and RMS error of the wavefront measurement. Although only ballistic light in the excitation path is corrected, the intensity after wavefront correction increased by 1.5 times. When applying IF to a two-photon microscope with a near infra-red laser, this method would further extend the measurement depth and achieve high SNR for the wavefront sensor.
Abstract translation: 干涉测深（IF），而不是传统的几何聚焦，激发光到深埋在组织中的引导星，增加其荧光强度。 该方法可以延长波前测量的深度，并改善组织内部的校正，因为其能够抑制漫射光的散射和弹道光的差异。 结果显示波前测量的SNR和RMS误差提高了两倍以上。 虽然激励路径中只有弹道光被校正，波前校正后的强度增加了1.5倍。 当将IF应用于具有近红外激光器的双光子显微镜时，该方法将进一步扩展测量深度并实现波前传感器的高SNR。
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Patent Agency Ranking
96.发明授权公开(公告)号：US09395293B1
公开(公告)日：2016-07-19
申请号：US14594956
申请日：2015-01-12
Applicant: Verily Life Sciences LLC
Inventor： Victor Marcel Acosta , Adam Backer , John D. Perreault , Daniele Paolo Piponi
CPC classification number: G02B21/0064 , G01J3/0205 , G01J3/021 , G01J3/0229 , G01J3/0237 , G01J3/18 , G01J3/502 , G01J2003/1278 , G01J2003/468 , G01N21/255 , G01N21/27 , G01N2201/06113 , G01N2201/0675 , G02B5/1828 , G02B6/2931 , G02B21/06 , G02B21/361 , G02B26/0808 , G02F1/133553 , G02F1/23 , G02F1/292 , G06T7/11 , G06T7/90 , G06T2207/10024 , G06T2207/10056 , G06T2207/10064 , G06T2207/30004 , H04N5/2256 , H04N5/332
Abstract: An imaging system includes a light source configured to illuminate a target and a camera configured to image light responsively emitted from the target and reflected from a spatial light modulator (SLM). The imaging system is configured to generate high-resolution, hyperspectral images of the target. The SLM includes a refractive layer that is chromatically dispersive and that has a refractive index that is controllable. The refractive index of the refractive layer can be controlled to vary according to a gradient such that light reflected from the SLM is chromatically dispersed and spectrographic information about the target can be captured using the camera. Such a system could be operated confocally, e.g., by incorporating a micromirror device configured to control a spatial pattern of illumination of the target and to modulate the transmission of light from the target to the camera via the SLM according to a corresponding spatial pattern.
Abstract translation: 成像系统包括被配置为照射目标的光源和被配置为对从目标发射并从空间光调制器（SLM）反射的）反射的图像的照相机。 成像系统被配置为产生目标的高分辨率，高光谱图像。 SLM包括色度分散且具有可控制的折射率的折射层。 折射层的折射率可以根据梯度来变化，使得从SLM反射的光被色散，并且可以使用照相机捕获关于目标的光谱信息。 这样的系统可以协调地操作，例如通过结合配置成控制目标的照明的空间模式的微镜装置，并且根据对应的空间模式经由SLM调制从目标到照相机的光的传输。
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97.发明申请METHOD AND APPARATUS FOR COMBINATION OF LOCALIZATION MICROSCOPY AND STRUCTURED ILLUMINATION MICROSCOPY 有权本地化显微镜和结构化照明显微镜的组合方法与装置公开(公告)号：US20160124208A1
公开(公告)日：2016-05-05
申请号：US14890243
申请日：2014-05-07
Inventor： Gerrit Best , Christoph Cremer , Sabrina Rossberger , Stefan Dithmar
CPC classification number: G02B21/367 , G01N21/6445 , G01N21/6458 , G01N2201/0675 , G02B21/0076 , G02B21/16 , G02B21/361 , G02B27/58
Abstract: A fluorescence microscope for obtaining super-resolution images of a sample labeled with at least one fluorescent label by combining localization microscopy and structured illumination microscopy is provided. The fluorescence microscope includes one or more light sources, an illumination system having a structured illumination path for illuminating the sample with structured illumination light and a localization illumination path for illuminating the sample with localization illumination light.
Abstract translation: 提供了一种用于通过组合定位显微镜和结构化照明显微镜获得用至少一种荧光标记物标记的样品的超分辨率图像的荧光显微镜。 荧光显微镜包括一个或多个光源，具有用于用结构化照明光照射样品的结构化照明路径的照明系统和用于用定位照明光照亮样品的定位照明路径。
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公开(公告)号：US20150362713A1
公开(公告)日：2015-12-17
申请号：US14660906
申请日：2015-03-17
Applicant: Howard Hughes Medical Institute
Inventor： Robert E. Betzig , Kai Wang
CPC classification number: G02B21/0064 , G01N21/6458 , G01N2021/6419 , G01N2201/0675 , G02B21/0056 , G02B21/006 , G02B21/0072 , G02B21/0076 , G02B21/008 , G02B21/361 , G02B26/06
Abstract: Excitation light is focused to a focus within a sample and the focus is scanned within a volume in the sample with scanning optical elements. Signal light emitted from the focus is de-scanned, with the one or more scanning optical elements, onto a wavefront sensor as the focus is scanned within the volume. Based on the descanned signal light, an average aberration created by the volume of the sample of a wavefront of the excitation light is determined. A wavefront of the excitation light is corrected by an amount according to the determined average aberration while the focus is scanned within the volume, the signal light is imaged onto a photosensitive detector as the focus is scanned within the volume, and a wavefront of the imaged signal light is corrected by an amount according to the determined average aberration while the focus is scanned. These steps can be repeated for a plurality of different volumes in the sample, and an image of the sample can be generated based on the detected signal light from scanned foci within the different volumes.
Abstract translation: 激发光聚焦到样品中的焦点，并用扫描光学元件在样品中的体积内扫描焦点。 当聚焦在体积内被扫描时，从焦点发出的信号光与一个或多个扫描光学元件一起被扫描到波前传感器上。 基于下拉信号光，确定由激发光的波前的样本的体积产生的平均像差。 当在体积内扫描焦点时，根据确定的平均像差来校正激发光的波前，当体积内的焦点被扫描时，信号光被成像到光敏检测器上，并且成像的波前 当扫描焦点时，根据确定的平均像差校正信号光的量。 可以对样本中的多个不同体积重复这些步骤，并且可以基于来自不同体积内的扫描焦点的检测到的信号光来生成样本的图像。
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公开(公告)号：US20150260640A1
公开(公告)日：2015-09-17
申请号：US14362392
申请日：2012-11-30
Applicant: THE UNIVERSITY OF NOTTINGHAM
Inventor： Stephen Sharples , Roger Light
IPC: G01N21/17
CPC classification number: G01N21/1702 , G01H9/00 , G01N2201/0612 , G01N2201/0675 , H01L27/14609
Abstract: An optical detector comprises a plurality of pixels, each pixel comprising a photodiode operable to detect light incident on that pixel and to generate a signal indicative of an intensity of that light. The plurality of pixels comprises a plurality of pixel pairs, and for each pixel pair, in a configuration mode, the detector is arranged to compare the signal generated by a first pixel of the pair with the signal generated by a second pixel of the pair. A method of optical detection is also described, as is a system incorporating the described optical detector.
Abstract translation: 光学检测器包括多个像素，每个像素包括可操作以检测入射在该像素上的光并产生指示该光强度的信号的光电二极管。 多个像素包括多个像素对，并且对于每个像素对，在配置模式中，检测器被布置为将由该对的第一像素生成的信号与由该对的第二像素生成的信号进行比较。 还描述了光学检测的方法，并且还包括结合所描述的光学检测器的系统。
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100.发明授权Method and system for optical data acquisition and tomography imaging of a turbid medium object 有权浑浊介质物质的光学数据采集和层析成像的方法和系统公开(公告)号：US09134229B2
公开(公告)日：2015-09-15
申请号：US13497290
申请日：2010-09-22
Applicant: Frédéric Lesage , Samuel Bélanger , Maxime Abran , Jean Provost
Inventor： Frédéric Lesage , Samuel Bélanger , Maxime Abran , Jean Provost
CPC classification number: G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , G01N21/6456 , G01N21/763 , G01N2021/1787 , G01N2021/479 , G01N2201/0675
Abstract: A system and method for optical data acquisition of an illuminated turbid medium object, the system comprises a variable structured light detector and a controller. The light detector is adapted to retrieve light from a plurality of detection points of an output surface of the illuminated turbid medium object with a plurality of detection patterns. The controller is adapted to control the variable structured light detector for the variable structured light detector to use a detection pattern corresponding to an illumination pattern of the illuminated turbid medium object. The light detector is further adapted to optically measure a combination of retrieved light from the plurality of detection points as an optical measurement. The controller is further adapted to store an illumination pattern identifier indicative of the illumination pattern, a detection pattern identifier indicative of the detection pattern and the corresponding optical measurement.
Abstract translation: 一种用于光学数据采集的照明混浊介质物体的系统和方法，该系统包括可变结构光检测器和控制器。 光检测器适于用多个检测图案从照明的浑浊介质物体的输出表面的多个检测点检索光。 控制器适于控制可变结构光检测器的可变结构光检测器，以使用与照明混浊介质物体的照明图案相对应的检测图案。 光检测器还适于光学测量来自多个检测点的检索光的组合作为光学测量。 控制器还适于存储指示照明模式的照明模式标识符，指示检测模式的检测模式标识符和对应的光学测量。
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