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公开(公告)号：US20240024432A1
公开(公告)日：2024-01-25
申请号：US18464025
申请日：2023-09-08
发明人： Xiaocheng Chen , Mark S. Dennis , Mihalis Kariolis , Adam P. Silverman , Ankita Srivastava , Ryan J. Watts , Robert C. Wells , Joy Yu Zuchero
CPC分类号： A61K38/40 , A61K47/644 , C07K16/2881 , C07K14/79 , C07K2317/52 , C07K2317/526 , C07K2317/94 , A61K38/00
摘要： Provided herein are polypeptides that bind to a transferrin receptor, Fc dimers and fusion proteins comprising such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
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公开(公告)号：US20230416205A1
公开(公告)日：2023-12-28
申请号：US18037999
申请日：2021-11-19
发明人： Alex L. Bagdasarian , Cyril Bucher , Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Benjamin J. Huffman , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
CPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US11851433B2
公开(公告)日：2023-12-26
申请号：US17494336
申请日：2021-10-05
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Anantha Sudhakar , Zachary K. Sweeney , Javier De Vicente Fidalgo
IPC分类号： C07D267/08 , A61K31/553 , A61P25/00 , A61P25/16 , A61P25/28 , C07D487/04 , C07D498/04
CPC分类号： C07D487/04 , C07D498/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US20230192887A1
公开(公告)日：2023-06-22
申请号：US17819182
申请日：2022-08-11
CPC分类号： C07K16/32 , C07K16/2881 , A61P35/00 , A61P35/04 , A61P25/00 , A61K2039/505
摘要： In one aspect, bispecific proteins having the ability to specifically bind to both subdomain II of human HER2 and subdomain IV of human HER2 are provided. In another aspect, methods of treating a cancer or treating brain metastasis of a cancer using a bispecific protein that specifically binds to subdomain II and subdomain IV of human HER2 are provided.
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公开(公告)号：US11643446B2
公开(公告)日：2023-05-09
申请号：US17697771
申请日：2022-03-17
发明人： Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L. Y. Low , Rachel Prorok , Ankita Srivastava
IPC分类号： C07K14/47 , A61P25/28 , C07K14/475 , A61K38/00
CPC分类号： C07K14/47 , A61P25/28 , C07K14/475 , A61K38/00 , C07K2319/30
摘要： Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US11591316B2
公开(公告)日：2023-02-28
申请号：US17401833
申请日：2021-08-13
发明人： Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Joseph P. Lyssikatos , Zachary K. Sweeney
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/20 , C07D498/04 , C07B59/00 , C07D403/14 , C07D405/14 , C07D409/14 , C07D487/04
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.
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公开(公告)号：US20220411433A1
公开(公告)日：2022-12-29
申请号：US17531039
申请日：2021-11-19
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： C07D491/048 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20220184186A1
公开(公告)日：2022-06-16
申请号：US17600527
申请日：2020-04-03
发明人： Dana ANDERSEN , Adam CATHERMAN , Tina GIESE , Gunasekaran KANNAN , Mihalis KARIOLIS , Cathal MAHON , Ankit PATEL
摘要： Certain embodiments provide a pharmaceutical composition comprising: a protein molecule comprising an ERT enzyme-Fc fusion polypeptide and a modified Fc polypeptide; a buffer; an isotonicity agent; a surfactant; and a stabilizer; wherein the pH of the pharmaceutical composition is about 5.5 to 7.0, as well as methods of use thereof.
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公开(公告)号：US20220073609A1
公开(公告)日：2022-03-10
申请号：US17403406
申请日：2021-08-16
发明人： Mark S. Dennis , Sherie Duncan , Kathleen Lisaingo , Kathryn M. Monroe , Joshua I. Park , Rachel Prorok , Ju Shi , Ankita Srivastava , Bettina Van Lengerich , Riley Walsh
IPC分类号： C07K16/28
摘要： In one aspect, antibodies that specifically bind to a human triggering receptor expressed on myeloid cells 2 (TREM2) protein are provided. In some embodiments, the antibody decreases levels of soluble TREM2 (sTREM2). In some embodiments, the antibody enhances TREM2 activity.
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公开(公告)号：US20220025039A1
公开(公告)日：2022-01-27
申请号：US17296506
申请日：2019-11-26
发明人： Giuseppe ASTARITA , Gilbert DI PAOLO , Kai Lin LIN , Kathryn M. MONROE , Alicia A. NUGENT , Bettina VAN LENGERICH
摘要： Certain embodiments described herein provide a method for treating dysregulated lipid metabolism and/or inflammation in a mammal in need thereof, comprising administering to the mammal an effective amount of an agonist anti-triggering receptor expressed on myeloid cells 2 (TREM2) antibody.
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