公开(公告)号：US20240150736A1

公开(公告)日：2024-05-09

申请号：US18411592

申请日：2024-01-12

Applicant: DENALI THERAPEUTICS INC.

Inventor： Tina GIESE ,  Gunasekaran KANNAN ,  Mihalis S. KARIOLIS ,  Cathal S. MAHON

IPC: C12N9/14 ,  A61K38/46 ,  A61P3/00

CPC classification number: C12N9/14 ,  A61K38/46 ,  A61P3/00 ,  C12Y310/01001 ,  C07K2319/30

Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.

公开(公告)号：US20220184186A1

公开(公告)日：2022-06-16

申请号：US17600527

申请日：2020-04-03

Applicant: DENALI THERAPEUTICS INC.

Inventor： Dana ANDERSEN ,  Adam CATHERMAN ,  Tina GIESE ,  Gunasekaran KANNAN ,  Mihalis KARIOLIS ,  Cathal MAHON ,  Ankit PATEL

IPC: A61K38/46 ,  A61K47/26 ,  A61K47/18

Abstract: Certain embodiments provide a pharmaceutical composition comprising: a protein molecule comprising an ERT enzyme-Fc fusion polypeptide and a modified Fc polypeptide; a buffer; an isotonicity agent; a surfactant; and a stabilizer; wherein the pH of the pharmaceutical composition is about 5.5 to 7.0, as well as methods of use thereof.

公开(公告)号：US20240148866A1

公开(公告)日：2024-05-09

申请号：US18276823

申请日：2022-02-11

Applicant: DENALI THERAPEUTICS INC.

Inventor： Annie ARGUELLO ,  Tina GIESE ,  Gunasekaran KANNAN ,  Mihalis S. KARIOLIS ,  Cathal S. MAHON ,  Junhua WANG

IPC: A61K39/395 ,  A61K38/46 ,  A61P3/00 ,  C07K16/28 ,  C12N9/16

CPC classification number: A61K39/3955 ,  A61K38/465 ,  A61P3/00 ,  C07K16/2881 ,  C12N9/16 ,  C12Y301/06013 ,  A61K2039/545

Abstract: Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferrin receptor (TfR) antibody as described herein, as well as methods of use thereof.

公开(公告)号：US20230062800A1

公开(公告)日：2023-03-02

申请号：US17855543

申请日：2022-06-30

Applicant: DENALI THERAPEUTICS INC.

Inventor： Tina GIESE ,  Gunasekaran KANNAN ,  Mihalis KARIOLIS ,  Cathal MAHON

IPC: C12N9/14 ,  A61P3/00 ,  A61K38/46

Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.