公开(公告)号：US20230062800A1

公开(公告)日：2023-03-02

申请号：US17855543

申请日：2022-06-30

Applicant: DENALI THERAPEUTICS INC.

Inventor： Tina GIESE ,  Gunasekaran KANNAN ,  Mihalis KARIOLIS ,  Cathal MAHON

IPC: C12N9/14 ,  A61P3/00 ,  A61K38/46

Abstract: Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.

公开(公告)号：US20220184186A1

公开(公告)日：2022-06-16

申请号：US17600527

申请日：2020-04-03

Applicant: DENALI THERAPEUTICS INC.

Inventor： Dana ANDERSEN ,  Adam CATHERMAN ,  Tina GIESE ,  Gunasekaran KANNAN ,  Mihalis KARIOLIS ,  Cathal MAHON ,  Ankit PATEL

IPC: A61K38/46 ,  A61K47/26 ,  A61K47/18

Abstract: Certain embodiments provide a pharmaceutical composition comprising: a protein molecule comprising an ERT enzyme-Fc fusion polypeptide and a modified Fc polypeptide; a buffer; an isotonicity agent; a surfactant; and a stabilizer; wherein the pH of the pharmaceutical composition is about 5.5 to 7.0, as well as methods of use thereof.

公开(公告)号：US20200277584A1

公开(公告)日：2020-09-03

申请号：US16649943

申请日：2018-10-01

Applicant: DENALI THERAPEUTICS INC.

Inventor： Giuseppe ASTARITA ,  Mark S. DENNIS ,  Jennifer A. GETZ ,  Anastasia HENRY ,  Mihalis KARIOLIS ,  Cathal MAHON ,  Adam P. SILVERMAN ,  Ankita SRIVASTAVA ,  Julie ULLMAN ,  Junhua WANG ,  Joy Yu ZUCHERO

IPC: C12N9/18 ,  C07K16/28 ,  C12N9/24 ,  A61K47/68

Abstract: Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.