公开(公告)号：US20240148866A1

公开(公告)日：2024-05-09

申请号：US18276823

申请日：2022-02-11

申请人： DENALI THERAPEUTICS INC.

发明人： Annie ARGUELLO ,  Tina GIESE ,  Gunasekaran KANNAN ,  Mihalis S. KARIOLIS ,  Cathal S. MAHON ,  Junhua WANG

IPC分类号： A61K39/395 ,  A61K38/46 ,  A61P3/00 ,  C07K16/28 ,  C12N9/16

CPC分类号： A61K39/3955 ,  A61K38/465 ,  A61P3/00 ,  C07K16/2881 ,  C12N9/16 ,  C12Y301/06013 ,  A61K2039/545

摘要： Certain embodiments provide a fusion protein comprising an iduronate 2-sulfatase (IDS) amino acid sequence, an IDS variant amino acid sequence, or a catalytically active fragment thereof; and an anti-transferrin receptor (TfR) antibody as described herein, as well as methods of use thereof.

公开(公告)号：US20240150736A1

公开(公告)日：2024-05-09

申请号：US18411592

申请日：2024-01-12

申请人： DENALI THERAPEUTICS INC.

发明人： Tina GIESE ,  Gunasekaran KANNAN ,  Mihalis S. KARIOLIS ,  Cathal S. MAHON

IPC分类号： C12N9/14 ,  A61K38/46 ,  A61P3/00

CPC分类号： C12N9/14 ,  A61K38/46 ,  A61P3/00 ,  C12Y310/01001 ,  C07K2319/30

摘要： Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.