公开(公告)号：US20230192887A1

公开(公告)日：2023-06-22

申请号：US17819182

申请日：2022-08-11

申请人： Denali Therapeutics Inc.

发明人： Gunasekaran Kannan ,  Do Jin Kim ,  Wanda Kwan ,  Raymond Ka Hang Tong

IPC分类号： C07K16/32 ,  C07K16/28 ,  A61P35/00 ,  A61P35/04 ,  A61P25/00

CPC分类号： C07K16/32 ,  C07K16/2881 ,  A61P35/00 ,  A61P35/04 ,  A61P25/00 ,  A61K2039/505

摘要： In one aspect, bispecific proteins having the ability to specifically bind to both subdomain II of human HER2 and subdomain IV of human HER2 are provided. In another aspect, methods of treating a cancer or treating brain metastasis of a cancer using a bispecific protein that specifically binds to subdomain II and subdomain IV of human HER2 are provided.

公开(公告)号：US20240299575A1

公开(公告)日：2024-09-12

申请号：US18568076

申请日：2022-07-01

申请人： Denali Therapeutics Inc.

发明人： Scarlett Barker ,  Mark S. Dennis ,  Sarah L. Devos ,  Anthony A. Estrada ,  Mihalis S. Kariolis ,  Cathal S. Mahon ,  Lizanne G. Nilewski ,  Joshua I. Park ,  Lu Shan ,  Mai B. Thayer ,  Raymond Ka Hang Tong ,  Hai L. Tran ,  Robert C. Wells ,  Joy Yu Zuchero

IPC分类号： A61K47/68 ,  A61K9/00 ,  A61K39/00 ,  C07K16/28 ,  C12N15/113

CPC分类号： A61K47/6807 ,  A61K9/0019 ,  A61K47/6849 ,  C07K16/2881 ,  C12N15/1138 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/92 ,  C12N2310/113 ,  C12N2310/14

摘要： Provided herein are conjugates comprising proteins that bind to a transferrin receptor and oligonucleotides that are capable of modulating the expression of a target gene or sequence, as well as methods of use thereof.