公开(公告)号：US20230416205A1

公开(公告)日：2023-12-28

申请号：US18037999

申请日：2021-11-19

申请人： Denali Therapeutics Inc

发明人： Alex L. Bagdasarian ,  Cyril Bucher ,  Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Brian M. Fox ,  Cheng Hu ,  Benjamin J. Huffman ,  Katrina W. Lexa ,  Lizanne G. Nilewski ,  Maksim Osipov ,  Arun Thottumkara

IPC分类号： C07D217/24 ,  C07D401/12 ,  C07D471/04 ,  C07D401/14 ,  C07D493/08 ,  C07D491/107 ,  C07D413/08 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D417/14 ,  C07D498/04 ,  C07D405/14 ,  C07D495/04

CPC分类号： C07D217/24 ,  C07D401/12 ,  C07D471/04 ,  C07D401/14 ,  C07D493/08 ,  C07D491/107 ,  C07D413/08 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D417/14 ,  C07D498/04 ,  C07D405/14 ,  C07D495/04

摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

公开(公告)号：US20240299575A1

公开(公告)日：2024-09-12

申请号：US18568076

申请日：2022-07-01

申请人： Denali Therapeutics Inc.

发明人： Scarlett Barker ,  Mark S. Dennis ,  Sarah L. Devos ,  Anthony A. Estrada ,  Mihalis S. Kariolis ,  Cathal S. Mahon ,  Lizanne G. Nilewski ,  Joshua I. Park ,  Lu Shan ,  Mai B. Thayer ,  Raymond Ka Hang Tong ,  Hai L. Tran ,  Robert C. Wells ,  Joy Yu Zuchero

IPC分类号： A61K47/68 ,  A61K9/00 ,  A61K39/00 ,  C07K16/28 ,  C12N15/113

CPC分类号： A61K47/6807 ,  A61K9/0019 ,  A61K47/6849 ,  C07K16/2881 ,  C12N15/1138 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/92 ,  C12N2310/113 ,  C12N2310/14

摘要： Provided herein are conjugates comprising proteins that bind to a transferrin receptor and oligonucleotides that are capable of modulating the expression of a target gene or sequence, as well as methods of use thereof.

公开(公告)号：US20230357162A1

公开(公告)日：2023-11-09

申请号：US18041539

申请日：2021-08-13

申请人： Denali Therapeutics Inc.

发明人： Alex L. Bagdasarian ,  Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Brian M. Fox ,  Cheng Hu ,  Benjamin J. Huffman ,  Katrina W. Lexa ,  Lizanne G. Nilewski ,  Maksim Osipov ,  Arun Thottumkara

IPC分类号： C07D237/32 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04 ,  C07D405/12 ,  C07D487/04 ,  C07D413/12

CPC分类号： C07D237/32 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

公开(公告)号：US20230348437A1

公开(公告)日：2023-11-02

申请号：US18001695

申请日：2021-07-01

申请人： Denali Therapeutics Inc.

发明人： Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Brian M. Fox ,  Cheng Hu ,  Katrina W. Lexa ,  Lizanne G. Nilewski ,  Maksim Osipov ,  Arun Thottumkara

IPC分类号： C07D403/12 ,  C07D237/14 ,  C07D401/12 ,  C07D401/04 ,  C07D253/07 ,  C07D403/14

CPC分类号： C07D403/12 ,  C07D237/14 ,  C07D253/07 ,  C07D401/04 ,  C07D401/12 ,  C07D403/14

摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.