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![SOLID FORMS OF 4-(3,3-DIFLUORO-2,2-DIMETHYL-PROPANOYL)-3,5-DIHYDRO-2H-PYRIDO[3,4-F][1,4]OXAZEPINE-9-CARBONITRILE](/abs-image/US/2024/01/25/US20240025915A1/abs.jpg.150x150.jpg)
1.发明公开公开(公告)号：US20240025915A1
公开(公告)日：2024-01-25
申请号：US18225236
申请日：2023-07-24
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07B2200/13
摘要： Described herein are solid forms of 4-(3,3-difluoro-2,2-dimethyl-propanoyl)-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile, the process of preparing the forms, pharmaceutical compositions comprising same, and methods of use thereof.
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公开(公告)号：US20230114472A1
公开(公告)日：2023-04-13
申请号：US17702718
申请日：2022-03-23
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D413/04 , C07D271/113 , C07D413/14 , C07D417/04 , C07D417/14 , C07D493/08
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20230416205A1
公开(公告)日：2023-12-28
申请号：US18037999
申请日：2021-11-19
发明人： Alex L. Bagdasarian , Cyril Bucher , Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Benjamin J. Huffman , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
CPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US20220411433A1
公开(公告)日：2022-12-29
申请号：US17531039
申请日：2021-11-19
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： C07D491/048 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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![SOLID FORMS OF 4-(3,3-DIFLUORO-2,2-DIMETHYL-PROPANOYL)-3,5-DIHYDRO-2H-PYRIDO[3,4-F][1,4]OXAZEPINE-9-CARBONITRILE](/abs-image/US/2024/09/26/US20240317776A1/abs.jpg.150x150.jpg)
5.发明公开公开(公告)号：US20240317776A1
公开(公告)日：2024-09-26
申请号：US18582522
申请日：2024-02-20
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07B2200/13
摘要： Described herein are solid forms of 4-(3,3-difluoro-2,2-dimethyl-propanoyl)-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile, the process of preparing the forms, pharmaceutical compositions comprising same, and methods of use thereof.
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公开(公告)号：US11236100B2
公开(公告)日：2022-02-01
申请号：US16637718
申请日：2018-08-08
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R. H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： C07D491/048 , C07C235/22 , C07C233/05 , C07C217/52 , C07C211/38 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20210147435A1
公开(公告)日：2021-05-20
申请号：US16637718
申请日：2018-08-08
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： C07D491/048 , C07D413/04 , C07D271/10 , C07D249/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07C235/22 , C07D249/08 , C07D233/61 , C07D413/12 , C07D487/04 , C07D471/04 , C07D413/06 , C07D403/12 , C07D401/12 , C07D271/06 , C07D263/38 , C07D207/27 , C07D233/42 , C07D233/36 , C07D403/04 , C07D263/56 , C07D233/64 , C07D257/04 , C07D417/04 , C07D291/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US11851440B2
公开(公告)日：2023-12-26
申请号：US17531039
申请日：2021-11-19
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R. H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： A61K31/4245 , A61K31/4164 , A61K31/415 , A61K31/421 , C07D491/048 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
CPC分类号： C07D491/048 , A61K31/415 , A61K31/4164 , A61K31/421 , A61K31/4245 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20230357162A1
公开(公告)日：2023-11-09
申请号：US18041539
申请日：2021-08-13
发明人： Alex L. Bagdasarian , Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Benjamin J. Huffman , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D237/32 , C07D401/12 , C07D403/12 , C07D405/14 , C07D471/04 , C07D405/12 , C07D487/04 , C07D413/12
CPC分类号： C07D237/32 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US20230348437A1
公开(公告)日：2023-11-02
申请号：US18001695
申请日：2021-07-01
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D403/12 , C07D237/14 , C07D401/12 , C07D401/04 , C07D253/07 , C07D403/14
CPC分类号： C07D403/12 , C07D237/14 , C07D253/07 , C07D401/04 , C07D401/12 , C07D403/14
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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