公开(公告)号：US20230416205A1

公开(公告)日：2023-12-28

申请号：US18037999

申请日：2021-11-19

申请人： Denali Therapeutics Inc

发明人： Alex L. Bagdasarian ,  Cyril Bucher ,  Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Brian M. Fox ,  Cheng Hu ,  Benjamin J. Huffman ,  Katrina W. Lexa ,  Lizanne G. Nilewski ,  Maksim Osipov ,  Arun Thottumkara

IPC分类号： C07D217/24 ,  C07D401/12 ,  C07D471/04 ,  C07D401/14 ,  C07D493/08 ,  C07D491/107 ,  C07D413/08 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D417/14 ,  C07D498/04 ,  C07D405/14 ,  C07D495/04

CPC分类号： C07D217/24 ,  C07D401/12 ,  C07D471/04 ,  C07D401/14 ,  C07D493/08 ,  C07D491/107 ,  C07D413/08 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D417/14 ,  C07D498/04 ,  C07D405/14 ,  C07D495/04

摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

公开(公告)号：US20240254132A1

公开(公告)日：2024-08-01

申请号：US18579846

申请日：2022-07-15

申请人： Denali Therapeutics Inc.

发明人： Alex L. Bagdasarian ,  Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Benjamin J. Huffman ,  Katrina W. Lexa ,  Maksim Osipov ,  Arun Thottumkara

IPC分类号： C07D487/04 ,  A61K31/4747 ,  A61K31/506 ,  A61K31/519 ,  C07D401/12 ,  C07D491/107

CPC分类号： C07D487/04 ,  A61K31/4747 ,  A61K31/506 ,  A61K31/519 ,  C07D401/12 ,  C07D491/107

摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

公开(公告)号：US20230357162A1

公开(公告)日：2023-11-09

申请号：US18041539

申请日：2021-08-13

申请人： Denali Therapeutics Inc.

发明人： Alex L. Bagdasarian ,  Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Brian M. Fox ,  Cheng Hu ,  Benjamin J. Huffman ,  Katrina W. Lexa ,  Lizanne G. Nilewski ,  Maksim Osipov ,  Arun Thottumkara

IPC分类号： C07D237/32 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D471/04 ,  C07D405/12 ,  C07D487/04 ,  C07D413/12

CPC分类号： C07D237/32 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04

摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.