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公开(公告)号：US12129263B2
公开(公告)日：2024-10-29
申请号：US17511193
申请日：2021-10-26
发明人： Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Christopher R. H. Hale , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Elena Serra , Zachary K. Sweeney , Arun Thottumkara
IPC分类号： C07D498/04 , A61K31/553 , A61P3/10 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P37/00 , A61P43/00 , C07D223/16 , C07D267/04 , C07D267/14 , C07D413/14 , C07D498/10 , C07D519/00
CPC分类号： C07D498/04 , C07D223/16 , C07D267/04 , C07D267/14 , C07D413/14 , C07D519/00
摘要： The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors.
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公开(公告)号：US20230357162A1
公开(公告)日：2023-11-09
申请号：US18041539
申请日：2021-08-13
发明人： Alex L. Bagdasarian , Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Benjamin J. Huffman , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D237/32 , C07D401/12 , C07D403/12 , C07D405/14 , C07D471/04 , C07D405/12 , C07D487/04 , C07D413/12
CPC分类号： C07D237/32 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US20230348437A1
公开(公告)日：2023-11-02
申请号：US18001695
申请日：2021-07-01
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D403/12 , C07D237/14 , C07D401/12 , C07D401/04 , C07D253/07 , C07D403/14
CPC分类号： C07D403/12 , C07D237/14 , C07D253/07 , C07D401/04 , C07D401/12 , C07D403/14
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US20200087319A1
公开(公告)日：2020-03-19
申请号：US16684340
申请日：2019-11-14
发明人： Javier De Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Christopher R.H. Hale , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Elena Serra , Zachary K. Sweeney , Arun Thottumkara
IPC分类号： C07D498/04 , C07D223/16 , C07D267/14 , C07D413/14 , C07D267/04 , C07D519/00
摘要： The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors.
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公开(公告)号：US20200079784A1
公开(公告)日：2020-03-12
申请号：US16683970
申请日：2019-11-14
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Anantha Sudhakar , Zachary K. Sweeney , Javier De Vicente Fidalgo
IPC分类号： C07D487/04 , C07D498/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US20230416205A1
公开(公告)日：2023-12-28
申请号：US18037999
申请日：2021-11-19
发明人： Alex L. Bagdasarian , Cyril Bucher , Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Benjamin J. Huffman , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
CPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US11851433B2
公开(公告)日：2023-12-26
申请号：US17494336
申请日：2021-10-05
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Anantha Sudhakar , Zachary K. Sweeney , Javier De Vicente Fidalgo
IPC分类号： C07D267/08 , A61K31/553 , A61P25/00 , A61P25/16 , A61P25/28 , C07D487/04 , C07D498/04
CPC分类号： C07D487/04 , C07D498/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US11203600B2
公开(公告)日：2021-12-21
申请号：US16684340
申请日：2019-11-14
发明人： Javier De Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Christopher R. H. Hale , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Elena Serra , Zachary K. Sweeney , Arun Thottumkara
IPC分类号： A61K31/553 , A61P43/00 , C07D498/04 , C07D223/16 , C07D267/04 , C07D267/14 , C07D413/14 , C07D519/00
摘要： The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors.
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公开(公告)号：US11174262B2
公开(公告)日：2021-11-16
申请号：US16683970
申请日：2019-11-14
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Anantha Sudhakar , Zachary K. Sweeney , Javier De Vicente Fidalgo
IPC分类号： C07D487/10 , C07D495/14 , C07D495/20 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P25/00 , A61P25/16 , A61P25/28 , C07D487/04 , C07D498/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US20210332058A1
公开(公告)日：2021-10-28
申请号：US17350581
申请日：2021-06-17
发明人： Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cheng Hu , Maksim Osipov , Zachary K. Sweeney , Javier de Vicente Fidalgo , Arun Thottumkara
IPC分类号： C07D487/04 , G01N33/50 , C07K14/00 , G01N33/574 , G01N33/68
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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