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公开(公告)号：US12091392B2
公开(公告)日：2024-09-17
申请号：US17430570
申请日：2020-02-12
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Jianwen A. Feng , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D271/113
CPC分类号： C07D271/113
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20230416205A1
公开(公告)日：2023-12-28
申请号：US18037999
申请日：2021-11-19
发明人： Alex L. Bagdasarian , Cyril Bucher , Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Benjamin J. Huffman , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
CPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US11591316B2
公开(公告)日：2023-02-28
申请号：US17401833
申请日：2021-08-13
发明人： Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Joseph P. Lyssikatos , Zachary K. Sweeney
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/20 , C07D498/04 , C07B59/00 , C07D403/14 , C07D405/14 , C07D409/14 , C07D487/04
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.
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公开(公告)号：US20220411433A1
公开(公告)日：2022-12-29
申请号：US17531039
申请日：2021-11-19
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： C07D491/048 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US10709692B2
公开(公告)日：2020-07-14
申请号：US15780620
申请日：2016-12-02
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Philip Leslie , Joseph P. Lyssikatos , Carmela Napolitano , Alfonso Pozzan , Anantha Sudhakar , Zachary K. Sweeney , Federica Tonelli , Javier de Vicente Fidalgo
IPC分类号： A61K31/422 , C07D413/04 , C07D261/02 , A61P1/00 , A61P29/00 , A61K31/4439
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US20180353480A1
公开(公告)日：2018-12-13
申请号：US15780620
申请日：2016-12-02
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Philip Leslie , Joseph P. Lyssikatos , Carmela Napolitano , Alfonso Pozzan , Anantha Sudhakar , Zachary K. Sweeney , Federica Tonelli , Javier de Vicente Fidalgo
IPC分类号： A61K31/422 , A61K31/4439 , A61P1/00 , A61P29/00
CPC分类号： A61K31/422 , A61K31/4439 , A61K2121/00 , A61P1/00 , A61P29/00 , C07D261/02 , C07D413/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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![SOLID FORMS OF 4-(3,3-DIFLUORO-2,2-DIMETHYL-PROPANOYL)-3,5-DIHYDRO-2H-PYRIDO[3,4-F][1,4]OXAZEPINE-9-CARBONITRILE](/abs-image/US/2024/01/25/US20240025915A1/abs.jpg.150x150.jpg)
7.发明公开公开(公告)号：US20240025915A1
公开(公告)日：2024-01-25
申请号：US18225236
申请日：2023-07-24
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07B2200/13
摘要： Described herein are solid forms of 4-(3,3-difluoro-2,2-dimethyl-propanoyl)-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile, the process of preparing the forms, pharmaceutical compositions comprising same, and methods of use thereof.
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公开(公告)号：US20230114472A1
公开(公告)日：2023-04-13
申请号：US17702718
申请日：2022-03-23
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D413/04 , C07D271/113 , C07D413/14 , C07D417/04 , C07D417/14 , C07D493/08
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20220220094A1
公开(公告)日：2022-07-14
申请号：US17602480
申请日：2020-04-10
IPC分类号： C07D403/12
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, isotopically enriched analog, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or pharmaceutical composition thereof, and methods of making and using thereof.
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公开(公告)号：US11072618B2
公开(公告)日：2021-07-27
申请号：US16434533
申请日：2019-06-07
发明人： Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cheng Hu , Maksim Osipov , Zachary K. Sweeney , Javier de Vicente Fidalgo , Arun Thottumkara
IPC分类号： C07D487/04 , G01N33/50 , C07K14/00 , G01N33/574 , G01N33/68
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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