- 专利标题: Progranulin variants
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申请号: US17697771申请日: 2022-03-17
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公开(公告)号: US11643446B2公开(公告)日: 2023-05-09
- 发明人: Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L. Y. Low , Rachel Prorok , Ankita Srivastava
- 申请人: Denali Therapeutics Inc.
- 申请人地址: US CA South San Francisco
- 专利权人: Denali Therapeutics Inc.
- 当前专利权人: Denali Therapeutics Inc.
- 当前专利权人地址: US CA South San Francisco
- 代理机构: Kilpatrick Townsend & Stockton LLP
- 主分类号: C07K14/47
- IPC分类号: C07K14/47 ; A61P25/28 ; C07K14/475 ; A61K38/00
摘要:
Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
公开/授权文献
- US20220213155A1 PROGRANULIN VARIANTS 公开/授权日:2022-07-07
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