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公开(公告)号：US10711004B2
公开(公告)日：2020-07-14
申请号：US16558718
申请日：2019-09-03
Applicant: Genentech, Inc.
Inventor： Huifen Chen , Brian Safina , Daniel Shore , Jack Terrett , Elisia Villemure , Matthew Volgraf , Stuart Ward , Aijun Lu , Robin Larouche-Gauthier , Francis Beaumier , Martin Dery , Lea Constantineau-Forget , Chantal Grand-Maitre , Luce Lepissier
IPC: C07D473/30 , C07D471/04 , C07D487/04 , C07D473/08
Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
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公开(公告)号：US20190263794A1
公开(公告)日：2019-08-29
申请号：US16398795
申请日：2019-04-30
Applicant: Genentech, Inc.
Inventor： Sarah M. Bronner , James J. Crawford , Andrew Cridland , Patrick Cyr , Benjamin Fauber , Emanuela Gancia , Alberto Gobbi , Christopher Hurley , Jonathan Killen , Wendy Lee , Olivier Rene , Monique Bodil Van Niel , Stuart Ward , Paul Winship , Jason Zbieg
IPC: C07D413/14 , C07D403/14 , C07D405/14
Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
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公开(公告)号：US10280144B2
公开(公告)日：2019-05-07
申请号：US15801192
申请日：2017-11-01
Applicant: Genentech, Inc.
Inventor： Benjamin Fauber , James J. Crawford , Sarah M. Bronner , Monique Bodil van Niel , Andrew Cridland , Emanuela Gancia , Christopher Hurley , Jonathan Killen , Stuart Ward
IPC: C07D237/26 , C07D237/28
Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, A, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
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公开(公告)号：US09981916B2
公开(公告)日：2018-05-29
申请号：US14533358
申请日：2014-11-05
Applicant: Genentech, Inc.
Inventor： Monique Bodil van Niel , Andrew Cridland , Benjamin Fauber , Alberto Gobbi , Christopher Hurley , David Hurst , Jonathan Killen , Robert Maxey , Stuart Ward
IPC: C07D237/28 , C07D403/06 , C07D413/06 , C07D401/04 , C07D417/04 , C07D405/12 , C07D491/048 , C07D403/14 , C07D491/107 , C07D401/12
CPC classification number: C07D237/28 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/14 , C07D405/12 , C07D413/06 , C07D417/04 , C07D491/048 , C07D491/107
Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
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公开(公告)号：US20140031330A1
公开(公告)日：2014-01-30
申请号：US13939962
申请日：2013-07-11
Applicant: Genentech, Inc.
Inventor： Monique Bodil van Niel , Benjamin Fauber , Simon Gaines , Alberto Gobbi , Olivier Rene , David Vesey , Stuart Ward
IPC: C07D487/04 , C07D417/12 , C07D471/04 , C07D295/185
CPC classification number: C07D295/185 , C07D275/02 , C07D279/02 , C07D281/02 , C07D291/02 , C07D417/10 , C07D417/12 , C07D417/14 , C07D451/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/10 , C07D498/10 , C07D513/10 , C07D515/12
Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。
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Patent Agency Ranking
公开(公告)号：US11008312B2
公开(公告)日：2021-05-18
申请号：US16398795
申请日：2019-04-30
Applicant: Genentech, Inc.
Inventor： Sarah M. Bronner , James J. Crawford , Andrew Cridland , Patrick Cyr , Benjamin Fauber , Emanuela Gancia , Alberto Gobbi , Christopher Hurley , Jonathan Killen , Wendy Lee , Olivier Rene , Monique Bodil Van Niel , Stuart Ward , Paul Winship , Jason Zbieg
IPC: C07D413/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D401/14
Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, p, q A, B, R1, R2, R3, R4, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
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公开(公告)号：US10913742B2
公开(公告)日：2021-02-09
申请号：US16421114
申请日：2019-05-23
Applicant: Genentech, Inc.
Inventor： Huifen Chen , Daniel Shore , Elisia Villemure , Matthew Volgraf , Baihua Hu , Aijun Lu , Andrew Cridland , Stuart Ward , Francis Beaumier , Martin Dery , Robin Larouche-Gauthier
IPC: C07D487/04 , C07D473/30 , C07D471/04 , C07D513/04 , A61K31/519 , A61P11/06 , C07D498/04
Abstract: The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.
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公开(公告)号：US09115101B2
公开(公告)日：2015-08-25
申请号：US13939962
申请日：2013-07-11
Applicant: Genentech, Inc.
Inventor： Monique Bodil van Niel , Benjamin Fauber , Simon Gaines , Alberto Gobbi , Olivier Rene , David Vesey , Stuart Ward
IPC: C07D417/10 , C07D417/12 , C07D417/14 , C07D279/02 , C07D281/02 , C07D291/02 , C07D295/185 , C07D491/10 , C07D513/10 , A61K31/541 , A61P19/02 , C07D451/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D275/02 , C07D498/10 , C07D515/12
CPC classification number: C07D295/185 , C07D275/02 , C07D279/02 , C07D281/02 , C07D291/02 , C07D417/10 , C07D417/12 , C07D417/14 , C07D451/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/10 , C07D498/10 , C07D513/10 , C07D515/12
Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。
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公开(公告)号：US20150197529A1
公开(公告)日：2015-07-16
申请号：US14593260
申请日：2015-01-09
Applicant: Genentech, Inc.
Inventor： Benjamin Fauber , Alberto Gobbi , Olivier Rene , Monique Bodil van Niel , Emanuela Gancia , Simon Gaines , Tammy Laddywahetty , David Vesey , Stuart Ward , Paul Winship
IPC: C07D491/113 , C07D491/107 , C07D417/12 , C07D417/14 , C07D279/02
CPC classification number: C07D417/10 , C07D279/02 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/107 , C07D491/113
Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
Abstract translation: 式I化合物或其药学上可接受的盐，其中m，n，p，q，r，A，W，X1，X2，X3，X4，Y，Z，R1，R2，R3，R4，R5，R6 ，R7，R8，R9，R10，R11和R12如本文所定义。 还公开了制备化合物和使用该化合物治疗炎性疾病如关节炎的方法。
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公开(公告)号：US20180222882A1
公开(公告)日：2018-08-09
申请号：US15801201
申请日：2017-11-01
Applicant: Genentech, Inc.
Inventor： Benjamin Fauber , Monique Bodil van Niel , Andrew Cridland , Christopher Hurley , Jonathan Killen , Stuart Ward
IPC: C07D401/04 , C07D403/04 , C07D405/04 , C07D413/14 , C07D403/14 , C07D405/14 , C07D401/14 , C07D491/107 , A61P19/02 , A61P25/28 , A61P17/06 , A61P1/00 , A61P11/00 , A61P11/06
CPC classification number: C07D401/04 , A61P1/00 , A61P11/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/28 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D491/107
Abstract: Compounds of formula I: or pharmaceutical salts thereof, wherein m, n, A, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
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