-
公开(公告)号：US11236046B2
公开(公告)日：2022-02-01
申请号：US16657102
申请日：2019-10-18
申请人： Genentech, Inc.
发明人： Huifen Chen , Yanyan Chu , Steven Do , Anthony Estrada , Baihua Hu , Aleksandr Kolesnikov , Xingyu Lin , Joseph P. Lyssikatos , Daniel Shore , Vishal Verma , Lan Wang , Guosheng Wu , Po-wai Yuen
IPC分类号： C07D207/48 , C07D403/12 , C07D401/14 , C07D401/12 , C07D403/14 , C07D417/12 , C07D451/02 , C07D491/048 , C07D405/14
摘要： The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
-
公开(公告)号：US10695348B2
公开(公告)日：2020-06-30
申请号：US16269973
申请日：2019-02-07
申请人： Genentech, Inc.
发明人： Vishal Verma , Matthew Volgraf , Baihua Hu
IPC分类号： C07D401/02 , C07D401/12 , C07D401/14 , C07D515/04 , A61K31/506 , C07D491/048 , A61P11/00
摘要： The invention provides compounds of formula I: and pharmaceutically acceptable salts thereof where R1 is a substituted or unsubstituted phenyl or a fused bicyclic comprising a substituted or unsubstituted phenyl. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
-
公开(公告)号：US20180118680A1
公开(公告)日：2018-05-03
申请号：US15851322
申请日：2017-12-21
申请人： Genentech, Inc.
发明人： Huifen Chen , Yanyan Chu , Steven Do , Anthony Estrada , Baihua Hu , Aleksandr Kolesnikov , Xingyu Lin , Joseph P. Lyssikatos , Daniel Shore , Vishal Verma , Lan Wang , Guosheng Wu , Po-wai Yuen
IPC分类号： C07D207/48 , C07D403/14 , C07D417/12 , C07D403/12 , C07D451/02 , C07D405/14 , C07D401/14 , C07D491/048 , C07D401/12
摘要： The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
-
公开(公告)号：US20160200739A1
公开(公告)日：2016-07-14
申请号：US15074100
申请日：2016-03-18
申请人： Genentech, Inc.
发明人： Nicole Blaquiere , Georgette Castanedo , Jianwen A. Feng , Baihua Hu , Steven Staben , Po-wai Yuen , Guosheng Wu , Jason Burch
IPC分类号： C07D513/04 , C07D401/14 , C07D413/14 , C07D471/04 , C07D413/10 , C07D401/10 , C07D403/10 , C07D491/052
CPC分类号： C07D513/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
-
公开(公告)号：US10179782B2
公开(公告)日：2019-01-15
申请号：US15042310
申请日：2016-02-12
申请人： Genentech, Inc.
发明人： Anthony Estrada , Elisia Villemure , Vishal Verma , Daniel Shore , Matthew Volgraf , Baihua Hu , Aijun Lu
IPC分类号： C07D417/14 , C07D403/12 , C07D401/14 , C07D405/14 , C07D401/12 , C07D403/14 , C07D409/14 , C07D417/12 , C07F9/6512
摘要： The invention is concerned with the compounds of formula I: and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.
-
公开(公告)号：US20180282328A1
公开(公告)日：2018-10-04
申请号：US15942321
申请日：2018-03-30
申请人： Genentech, Inc.
发明人： Bryan Chan , Blake Daniels , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Malcolm Huestis , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Michael Siu , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Emanuela Gancia , Graham Jones , Michael Lainchbury , Andrew Madin , Eileen Seward , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu , Baihua Hu , Aijun Lu
IPC分类号： C07D471/04 , A61K45/06 , A61P35/00 , A61K31/444 , A61K31/4375 , A61K31/506 , C07D519/00 , A61K31/4545 , A61K31/4725 , A61K31/5383 , A61K31/496 , A61K31/5377 , A61K31/5025 , A61K31/551 , A61K31/55
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61K31/551 , A61K45/06 , A61P35/00 , C07D519/00
摘要： Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
-
公开(公告)号：US20150065482A1
公开(公告)日：2015-03-05
申请号：US14466153
申请日：2014-08-22
申请人： Genentech, Inc.
发明人： Nicole Blaquiere , Georgette Castanedo , Jianwen A. Feng , Baihua Hu , Steven Staben , Po-wai Yuen , Guosheng Wu , Jason Burch
IPC分类号： C07D513/04 , C07D471/04 , C07D403/10 , C07D401/14 , C07D413/10 , C07D491/052 , C07D487/04 , C07D401/10
CPC分类号： C07D513/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
摘要翻译： 本发明涉及式（O）的化合物：其中Q，A1-A8，R4和R5各自具有如本文所述的含义。 式（0）的化合物及其药物组合物可用于治疗其中观察到NF-kB信号传导的不期望或过度活化的疾病和病症。
-
公开(公告)号：US10913742B2
公开(公告)日：2021-02-09
申请号：US16421114
申请日：2019-05-23
申请人： Genentech, Inc.
发明人： Huifen Chen , Daniel Shore , Elisia Villemure , Matthew Volgraf , Baihua Hu , Aijun Lu , Andrew Cridland , Stuart Ward , Francis Beaumier , Martin Dery , Robin Larouche-Gauthier
IPC分类号： C07D487/04 , C07D473/30 , C07D471/04 , C07D513/04 , A61K31/519 , A61P11/06 , C07D498/04
摘要： The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.
-
公开(公告)号：US09605005B2
公开(公告)日：2017-03-28
申请号：US15074100
申请日：2016-03-18
申请人： Genentech, Inc.
发明人： Nicole Blaquiere , Georgette Castanedo , Jianwen A. Feng , Baihua Hu , Steven Staben , Po-wai Yuen , Guosheng Wu , Jason Burch
IPC分类号： C07D401/00 , C07D513/04 , C07D401/14 , C07D413/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D413/10 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
CPC分类号： C07D513/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04
摘要： The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
-
公开(公告)号：US20150057260A1
公开(公告)日：2015-02-26
申请号：US14466176
申请日：2014-08-22
申请人： Genentech, Inc.
发明人： Nicole Blaquiere , Georgette Castanedo , Jianwen A. Feng , Baihua Hu , Steven Staben , Po-wai Yuen , Guosheng Wu , Xingyu Lin , Jason Burch
IPC分类号： C07D495/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D491/107 , C07D403/14 , C07D401/10
CPC分类号： C07D401/10 , A61K31/395 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/107 , C07D495/04 , C07D495/06
摘要： The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.
摘要翻译： 本发明涉及式（O）的化合物：其中A1-A8，R4和R5各自具有如本文所述的含义。 式（0）的化合物及其药物组合物可用于治疗其中观察到NF-kB信号传导的不期望或过度活化的疾病和病症。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.044 秒)
